true2007-09-112024-03-2794AGE1_CAEBRThe genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.Stein L.D.Bao Z.Blasiar D.Blumenthal T.Brent M.R.Chen N.Chinwalla A.Clarke L.Clee C.Coghlan A.Coulson A.D'Eustachio P.Fitch D.H.A.Fulton L.A.Fulton R.E.Griffiths-Jones S.Harris T.W.Hillier L.W.Kamath R.Kuwabara P.E.Mardis E.R.Marra M.A.Miner T.L.Minx P.Mullikin J.C.Plumb R.W.Rogers J.Schein J.E.Sohrmann M.Spieth J.Stajich J.E.Wei C.Willey D.Wilson R.K.Durbin R.M.Waterston R.H.doi:10.1371/journal.pbio.00000452003PLoS Biol.1166-192NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]AF16Cbr-age-1EukaryotaC2_PI3K_likePI3KaC2 domainPhosphatidylinositol 3-/4-kinase, catalytic domainPhosphatidylinositol 3-kinase, accessory domain (PIK)ARM-type_foldC2_domain_sfKinase-like_dom_sfPI3/4_kinase_cat_domPI3/4_kinase_cat_sfPI3/4_kinase_CSPI3K-type_C2_domPI3K_ABDPI3K_accessory_domPI3K_accessory_sfPI3K_Ras-bd_domPI_KinaseUbiquitin-like_domsfPHOSPHATIDYLINOSITOL 3-KINASE AGE-1PHOSPHATIDYLINOSITOL KINASEPI3_PI4_kinasePI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3K_C2PI3K_p85BPI3K_rbdPI3KaPI3KcARM repeatC2 domain (Calcium/lipid-binding domain, CaLB)Protein kinase-like (PK-like)Ubiquitin-likeC2_PI3KPI3_4_KINASE_1PI3_4_KINASE_2PI3_4_KINASE_3PI3K_ABDPI3K_RBDPIK_HELICALPhosphatidylinositol 3-kinase age-1PI3-kinase age-1PI3K age-1PtdIns-3-kinase age-12.7.1.137Aging alteration protein 1age-1CBG02868Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning.Belongs to the PI3/PI4-kinase family.Phosphatidylinositol 3-kinase age-113393611159PI3K-ABD79179PI3K-RBD272363C2 PI3K-type430588PIK helical607793PI3K/PI4K catalytic858Disordered28G-loop864870Catalytic loop10281036Activation loop10471073Polar residues242007-09-1111339369bd684258a7a7376ff8e3a5d905defe1MSMGRSSSTTFRNRTASHGSRSLGSAETARIPRKLSSQLSHTHANILHPQLQTMMEQWQMRERPSLETENGKGSLLLSSEGVADMIVLSSFGEVISVVFPWFLANVRTSFDIKLSEFKHQLFEQIGPMKWGKHSTQPQDYAFRQLNNFGEIEVIFNDDQQLSCLELHGTFPMLFLFEPDGFNRDKELMCDISHCLGYSLDKLEESIDEELRQFRASLWTQTKKTCFERGVDGVDHYAFPEEQYFCVGEKCPTDLESKVKAAKLDYQLFWTKRKSEANEVWEKMYKITIDFDPEFNPQSLMRMFVKELQCMNLFDPEDPPDEEWILQLAGRTSFVTRPEISLVSYDGIRSELESYRCPGFVVRRKSLVLKDYVRPKPLYEPHYVRVHERKMALDVLSVSIGTEVKHSGNSDKVWTDFRPTASLEQITLWDLDSNLMIRPVNVTGLPFTASHDIYLGMEFKVYVGTLTLATIKIPRVPTTKLVWKREFFTFDLYMKDMPPSAILSVRVYSMKTTKMKEEIELGWVNISLSDWRDELRQGQIKLNLWGPEPSANRSRIGHNGAKIGTSLSVTVEISSHGRRVKMPNEAQYKYLVDHRISWSDTVEIVGDDYEACIGDPGYKKLQDLVKKHESGVILDDSEQRHVWSWRNYIQKQEPDLLVVLSELRIVWTDRENFSELYVMLETWKAPSVAAALTLLGKRCTDRVIRKFAVNKLNDQLSQFNVHLFLLPLIQALKYEPRAYSEVGMMLLTRALSSYRIGHRLFWLLRSEICRLKDCATNNEEYRRISLLMEAYLRGNEEHIKGIIRQVDMVDELTRISSLVKGLSKEAAREKLRDQLRTISHKMESIDSPLDPVYKFGEMVIEKAIVLGSAKQPLRLVWKNKNPKSDLHLPFCEVIFKNGDDLRQDMLVLQVLEVMDTIWKAANIDCCLSPYGVLPMGEMIGIIEVVPNCKTIFEIQHKAGLVNTAARSVDSNFMNKWIRKQCGFVDEKKKYKKGGGPTVDSAQATKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEQFLTIIRSGKPVDGNSHEIQKFKTLCLEAYEVMWNNLKYKFQKTLCCKGETKEKARKFFAGVYEEAFNGSWSTKTNWLFHAMKHYtruetruetruetruetruetruetruetrue