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P0C5E7

- AGE1_CAEBR

UniProt

P0C5E7 - AGE1_CAEBR

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Protein

Phosphatidylinositol 3-kinase age-1

Gene

age-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. aging Source: UniProtKB
  2. dauer larval development Source: UniProtKB
  3. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
Short name:
PI3-kinase age-1
Short name:
PI3K age-1
Short name:
PtdIns-3-kinase age-1
Alternative name(s):
Aging alteration protein 1
Gene namesi
Name:age-1
ORF Names:CBG02868
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG02868; CBP37622; WBGene00025837; Cbr-age-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11591159Phosphatidylinositol 3-kinase age-1PRO_0000304611Add
BLAST

Proteomic databases

PRIDEiP0C5E7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 179101PI3K-ABDPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 36392PI3K-RBDPROSITE-ProRule annotationAdd
BLAST
Domaini430 – 588159C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini607 – 793187PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini890 – 1159270PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-ABD domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
InParanoidiP0C5E7.
OrthoDBiEOG70CR65.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ
60 70 80 90 100
LQTMMEQWQM RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP
110 120 130 140 150
WFLANVRTSF DIKLSEFKHQ LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE
160 170 180 190 200
IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG FNRDKELMCD ISHCLGYSLD
210 220 230 240 250
KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE EQYFCVGEKC
260 270 280 290 300
PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM
310 320 330 340 350
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE
360 370 380 390 400
LESYRCPGFV VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG
410 420 430 440 450
TEVKHSGNSD KVWTDFRPTA SLEQITLWDL DSNLMIRPVN VTGLPFTASH
460 470 480 490 500
DIYLGMEFKV YVGTLTLATI KIPRVPTTKL VWKREFFTFD LYMKDMPPSA
510 520 530 540 550
ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK LNLWGPEPSA
560 570 580 590 600
NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT
610 620 630 640 650
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK
660 670 680 690 700
QEPDLLVVLS ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD
710 720 730 740 750
RVIRKFAVNK LNDQLSQFNV HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL
760 770 780 790 800
SSYRIGHRLF WLLRSEICRL KDCATNNEEY RRISLLMEAY LRGNEEHIKG
810 820 830 840 850
IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK MESIDSPLDP
860 870 880 890 900
VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL
910 920 930 940 950
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI
960 970 980 990 1000
FEIQHKAGLV NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA
1010 1020 1030 1040 1050
QATKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF
1060 1070 1080 1090 1100
GHILGHGKTK LGIQRDRQPF ILTEQFLTII RSGKPVDGNS HEIQKFKTLC
1110 1120 1130 1140 1150
LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA FNGSWSTKTN

WLFHAMKHY
Length:1,159
Mass (Da):133,936
Last modified:September 11, 2007 - v1
Checksum:i8D8D16AEF6CEFA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601438 Genomic DNA. Translation: CAP23732.2.

Genome annotation databases

EnsemblMetazoaiCBG02868; CBG02868; CBG02868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601438 Genomic DNA. Translation: CAP23732.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0C5E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG02868 ; CBG02868 ; CBG02868 .

Organism-specific databases

WormBasei CBG02868 ; CBP37622 ; WBGene00025837 ; Cbr-age-1.

Phylogenomic databases

eggNOGi COG5032.
InParanoidi P0C5E7.
OrthoDBi EOG70CR65.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiAGE1_CAEBR
AccessioniPrimary (citable) accession number: P0C5E7
Secondary accession number(s): A8WTC1, Q620C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3