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P0C5E7

- AGE1_CAEBR

UniProt

P0C5E7 - AGE1_CAEBR

Protein

Phosphatidylinositol 3-kinase age-1

Gene

age-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway By similarity.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. aging Source: UniProtKB
    2. dauer larval development Source: UniProtKB
    3. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
    Short name:
    PI3-kinase age-1
    Short name:
    PI3K age-1
    Short name:
    PtdIns-3-kinase age-1
    Alternative name(s):
    Aging alteration protein 1
    Gene namesi
    Name:age-1
    ORF Names:CBG02868
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG02868; CBP37622; WBGene00025837; Cbr-age-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11591159Phosphatidylinositol 3-kinase age-1PRO_0000304611Add
    BLAST

    Proteomic databases

    PRIDEiP0C5E7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 179101PI3K-ABDPROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 36392PI3K-RBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 588159C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 793187PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini890 – 1159270PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K-ABD domain.PROSITE-ProRule annotation
    Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    OrthoDBiEOG70CR65.

    Family and domain databases

    Gene3Di1.10.1070.11. 2 hits.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C5E7-1 [UniParc]FASTAAdd to Basket

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    MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ     50
    LQTMMEQWQM RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP 100
    WFLANVRTSF DIKLSEFKHQ LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE 150
    IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG FNRDKELMCD ISHCLGYSLD 200
    KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE EQYFCVGEKC 250
    PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM 300
    RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE 350
    LESYRCPGFV VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG 400
    TEVKHSGNSD KVWTDFRPTA SLEQITLWDL DSNLMIRPVN VTGLPFTASH 450
    DIYLGMEFKV YVGTLTLATI KIPRVPTTKL VWKREFFTFD LYMKDMPPSA 500
    ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK LNLWGPEPSA 550
    NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT 600
    VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK 650
    QEPDLLVVLS ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD 700
    RVIRKFAVNK LNDQLSQFNV HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL 750
    SSYRIGHRLF WLLRSEICRL KDCATNNEEY RRISLLMEAY LRGNEEHIKG 800
    IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK MESIDSPLDP 850
    VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL 900
    RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI 950
    FEIQHKAGLV NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA 1000
    QATKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF 1050
    GHILGHGKTK LGIQRDRQPF ILTEQFLTII RSGKPVDGNS HEIQKFKTLC 1100
    LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA FNGSWSTKTN 1150
    WLFHAMKHY 1159
    Length:1,159
    Mass (Da):133,936
    Last modified:September 11, 2007 - v1
    Checksum:i8D8D16AEF6CEFA08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601438 Genomic DNA. Translation: CAP23732.2.

    Genome annotation databases

    EnsemblMetazoaiCBG02868; CBG02868; CBG02868.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601438 Genomic DNA. Translation: CAP23732.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P0C5E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG02868 ; CBG02868 ; CBG02868 .

    Organism-specific databases

    WormBasei CBG02868 ; CBP37622 ; WBGene00025837 ; Cbr-age-1.

    Phylogenomic databases

    eggNOGi COG5032.
    OrthoDBi EOG70CR65.

    Family and domain databases

    Gene3Di 1.10.1070.11. 2 hits.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiAGE1_CAEBR
    AccessioniPrimary (citable) accession number: P0C5E7
    Secondary accession number(s): A8WTC1, Q620C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3