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P0C5E7 (AGE1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase age-1

Short name=PI3-kinase age-1
Short name=PI3K age-1
Short name=PtdIns-3-kinase age-1
EC=2.7.1.137
Alternative name(s):
Aging alteration protein 1
Gene names
Name:age-1
ORF Names:CBG02868
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K-ABD domain.

Contains 1 PI3K-RBD domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11591159Phosphatidylinositol 3-kinase age-1
PRO_0000304611

Regions

Domain79 – 179101PI3K-ABD
Domain272 – 36392PI3K-RBD
Domain430 – 588159C2 PI3K-type
Domain607 – 793187PIK helical
Domain890 – 1159270PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
P0C5E7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 8D8D16AEF6CEFA08

FASTA1,159133,936
        10         20         30         40         50         60 
MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ LQTMMEQWQM 

        70         80         90        100        110        120 
RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP WFLANVRTSF DIKLSEFKHQ 

       130        140        150        160        170        180 
LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG 

       190        200        210        220        230        240 
FNRDKELMCD ISHCLGYSLD KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE 

       250        260        270        280        290        300 
EQYFCVGEKC PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM 

       310        320        330        340        350        360 
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE LESYRCPGFV 

       370        380        390        400        410        420 
VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG TEVKHSGNSD KVWTDFRPTA 

       430        440        450        460        470        480 
SLEQITLWDL DSNLMIRPVN VTGLPFTASH DIYLGMEFKV YVGTLTLATI KIPRVPTTKL 

       490        500        510        520        530        540 
VWKREFFTFD LYMKDMPPSA ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK 

       550        560        570        580        590        600 
LNLWGPEPSA NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT 

       610        620        630        640        650        660 
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK QEPDLLVVLS 

       670        680        690        700        710        720 
ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD RVIRKFAVNK LNDQLSQFNV 

       730        740        750        760        770        780 
HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL SSYRIGHRLF WLLRSEICRL KDCATNNEEY 

       790        800        810        820        830        840 
RRISLLMEAY LRGNEEHIKG IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK 

       850        860        870        880        890        900 
MESIDSPLDP VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL 

       910        920        930        940        950        960 
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI FEIQHKAGLV 

       970        980        990       1000       1010       1020 
NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA QATKKYFESV DRFLYSCVGY 

      1030       1040       1050       1060       1070       1080 
SVATYIMGIK DRHSDNLMLT EDGKYFHIDF GHILGHGKTK LGIQRDRQPF ILTEQFLTII 

      1090       1100       1110       1120       1130       1140 
RSGKPVDGNS HEIQKFKTLC LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA 

      1150 
FNGSWSTKTN WLFHAMKHY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601438 Genomic DNA. Translation: CAP23732.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP0C5E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG02868; CBG02868; CBG02868.

Organism-specific databases

WormBaseCBG02868; CBP37622; WBGene00025837; Cbr-age-1.

Phylogenomic databases

eggNOGCOG5032.
OrthoDBEOG70CR65.

Family and domain databases

Gene3D1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGE1_CAEBR
AccessionPrimary (citable) accession number: P0C5E7
Secondary accession number(s): A8WTC1, Q620C1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families