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P0C5E7

- AGE1_CAEBR

UniProt

P0C5E7 - AGE1_CAEBR

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Protein
Phosphatidylinositol 3-kinase age-1
Gene
age-1, CBG02868
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. aging Source: UniProtKB
  2. dauer larval development Source: UniProtKB
  3. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
Short name:
PI3-kinase age-1
Short name:
PI3K age-1
Short name:
PtdIns-3-kinase age-1
Alternative name(s):
Aging alteration protein 1
Gene namesi
Name:age-1
ORF Names:CBG02868
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG02868; CBP37622; WBGene00025837; Cbr-age-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11591159Phosphatidylinositol 3-kinase age-1
PRO_0000304611Add
BLAST

Proteomic databases

PRIDEiP0C5E7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 179101PI3K-ABD
Add
BLAST
Domaini272 – 36392PI3K-RBD
Add
BLAST
Domaini430 – 588159C2 PI3K-type
Add
BLAST
Domaini607 – 793187PIK helical
Add
BLAST
Domaini890 – 1159270PI3K/PI4K
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K-ABD domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.
OrthoDBiEOG70CR65.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5E7-1 [UniParc]FASTAAdd to Basket

« Hide

MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ     50
LQTMMEQWQM RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP 100
WFLANVRTSF DIKLSEFKHQ LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE 150
IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG FNRDKELMCD ISHCLGYSLD 200
KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE EQYFCVGEKC 250
PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM 300
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE 350
LESYRCPGFV VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG 400
TEVKHSGNSD KVWTDFRPTA SLEQITLWDL DSNLMIRPVN VTGLPFTASH 450
DIYLGMEFKV YVGTLTLATI KIPRVPTTKL VWKREFFTFD LYMKDMPPSA 500
ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK LNLWGPEPSA 550
NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT 600
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK 650
QEPDLLVVLS ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD 700
RVIRKFAVNK LNDQLSQFNV HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL 750
SSYRIGHRLF WLLRSEICRL KDCATNNEEY RRISLLMEAY LRGNEEHIKG 800
IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK MESIDSPLDP 850
VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL 900
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI 950
FEIQHKAGLV NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA 1000
QATKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF 1050
GHILGHGKTK LGIQRDRQPF ILTEQFLTII RSGKPVDGNS HEIQKFKTLC 1100
LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA FNGSWSTKTN 1150
WLFHAMKHY 1159
Length:1,159
Mass (Da):133,936
Last modified:September 11, 2007 - v1
Checksum:i8D8D16AEF6CEFA08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601438 Genomic DNA. Translation: CAP23732.2.

Genome annotation databases

EnsemblMetazoaiCBG02868; CBG02868; CBG02868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601438 Genomic DNA. Translation: CAP23732.2 .

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi P0C5E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG02868 ; CBG02868 ; CBG02868 .

Organism-specific databases

WormBasei CBG02868 ; CBP37622 ; WBGene00025837 ; Cbr-age-1.

Phylogenomic databases

eggNOGi COG5032.
OrthoDBi EOG70CR65.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiAGE1_CAEBR
AccessioniPrimary (citable) accession number: P0C5E7
Secondary accession number(s): A8WTC1, Q620C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi