Phosphatidylinositol 3-kinase age-1 - Caenorhabditis briggsae

Preferred order of sections

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 3-kinase age-1
Short name=PI3-kinase age-1
Short name=PI3K age-1
Short name=PtdIns-3-kinase age-1
EC=2.7.1.137

Alternative name(s):
Aging alteration protein 1

Gene names

Name:	age-1
ORF Names:	CBG02868

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K-ABD domain.

Contains 1 PI3K-RBD domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from sequence or structural similarity. Source: UniProtKB dauer larval development Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol-3-phosphate biosynthetic process Inferred from electronic annotation. Source: GOC phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1159

1159

Phosphatidylinositol 3-kinase age-1

PRO_0000304611

Regions

Domain

79 – 179

101

PI3K-ABD

Domain

272 – 363

92

PI3K-RBD

Domain

430 – 588

159

C2 PI3K-type

Domain

607 – 793

187

PIK helical

Domain

890 – 1159

270

PI3K/PI4K

Sequences

Sequence

Length

Mass (Da)

Tools

P0C5E7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 8D8D16AEF6CEFA08
Show »

FASTA

1,159

133,936

        10         20         30         40         50         60 
MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ LQTMMEQWQM 

        70         80         90        100        110        120 
RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP WFLANVRTSF DIKLSEFKHQ 

       130        140        150        160        170        180 
LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG 

       190        200        210        220        230        240 
FNRDKELMCD ISHCLGYSLD KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE 

       250        260        270        280        290        300 
EQYFCVGEKC PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM 

       310        320        330        340        350        360 
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE LESYRCPGFV 

       370        380        390        400        410        420 
VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG TEVKHSGNSD KVWTDFRPTA 

       430        440        450        460        470        480 
SLEQITLWDL DSNLMIRPVN VTGLPFTASH DIYLGMEFKV YVGTLTLATI KIPRVPTTKL 

       490        500        510        520        530        540 
VWKREFFTFD LYMKDMPPSA ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK 

       550        560        570        580        590        600 
LNLWGPEPSA NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT 

       610        620        630        640        650        660 
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK QEPDLLVVLS 

       670        680        690        700        710        720 
ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD RVIRKFAVNK LNDQLSQFNV 

       730        740        750        760        770        780 
HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL SSYRIGHRLF WLLRSEICRL KDCATNNEEY 

       790        800        810        820        830        840 
RRISLLMEAY LRGNEEHIKG IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK 

       850        860        870        880        890        900 
MESIDSPLDP VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL 

       910        920        930        940        950        960 
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI FEIQHKAGLV 

       970        980        990       1000       1010       1020 
NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA QATKKYFESV DRFLYSCVGY 

      1030       1040       1050       1060       1070       1080 
SVATYIMGIK DRHSDNLMLT EDGKYFHIDF GHILGHGKTK LGIQRDRQPF ILTEQFLTII 

      1090       1100       1110       1120       1130       1140 
RSGKPVDGNS HEIQKFKTLC LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA 

      1150 
FNGSWSTKTN WLFHAMKHY

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References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics."
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W.

Waterston R.H.
PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE601438 Genomic DNA. Translation: CAP23732.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P0C5E7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG02868; CBG02868; CBG02868.
Organism-specific databases
WormBase	CBG02868; CBP37622; WBGene00025837; Cbr-age-1.
Phylogenomic databases
eggNOG	COG5032.
Family and domain databases
Gene3D	1.10.1070.11. 2 hits. 1.25.40.70. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR003113. PI3K_adapt-bd_dom. IPR002420. PI3K_C2_dom. IPR000341. PI3K_Ras-bd_dom. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50004. C2. False negative. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51544. PI3K_ABD. 1 hit. PS51547. PI3K_C2. 1 hit. PS51546. PI3K_RBD. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGE1_CAEBR

Accession

Primary (citable) accession number: P0C5E7
Secondary accession number(s): A8WTC1, Q620C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents