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Protein

Phosphatidylinositol 3-kinase age-1

Gene

age-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
Short name:
PI3-kinase age-1
Short name:
PI3K age-1
Short name:
PtdIns-3-kinase age-1
Alternative name(s):
Aging alteration protein 1
Gene namesi
Name:age-1
ORF Names:CBG02868
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome II, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG02868 ; CBP43879 ; WBGene00025837 ; Cbr-age-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046111 – 1159Phosphatidylinositol 3-kinase age-1Add BLAST1159

Proteomic databases

PRIDEiP0C5E7

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG02868

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 179PI3K-ABDPROSITE-ProRule annotationAdd BLAST101
Domaini272 – 363PI3K-RBDPROSITE-ProRule annotationAdd BLAST92
Domaini430 – 588C2 PI3K-typePROSITE-ProRule annotationAdd BLAST159
Domaini607 – 793PIK helicalPROSITE-ProRule annotationAdd BLAST187
Domaini890 – 1159PI3K/PI4KPROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
InParanoidiP0C5E7
OMAiFTEEVLW
OrthoDBiEOG091G027R

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ
60 70 80 90 100
LQTMMEQWQM RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP
110 120 130 140 150
WFLANVRTSF DIKLSEFKHQ LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE
160 170 180 190 200
IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG FNRDKELMCD ISHCLGYSLD
210 220 230 240 250
KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE EQYFCVGEKC
260 270 280 290 300
PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM
310 320 330 340 350
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE
360 370 380 390 400
LESYRCPGFV VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG
410 420 430 440 450
TEVKHSGNSD KVWTDFRPTA SLEQITLWDL DSNLMIRPVN VTGLPFTASH
460 470 480 490 500
DIYLGMEFKV YVGTLTLATI KIPRVPTTKL VWKREFFTFD LYMKDMPPSA
510 520 530 540 550
ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK LNLWGPEPSA
560 570 580 590 600
NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT
610 620 630 640 650
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK
660 670 680 690 700
QEPDLLVVLS ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD
710 720 730 740 750
RVIRKFAVNK LNDQLSQFNV HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL
760 770 780 790 800
SSYRIGHRLF WLLRSEICRL KDCATNNEEY RRISLLMEAY LRGNEEHIKG
810 820 830 840 850
IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK MESIDSPLDP
860 870 880 890 900
VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL
910 920 930 940 950
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI
960 970 980 990 1000
FEIQHKAGLV NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA
1010 1020 1030 1040 1050
QATKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF
1060 1070 1080 1090 1100
GHILGHGKTK LGIQRDRQPF ILTEQFLTII RSGKPVDGNS HEIQKFKTLC
1110 1120 1130 1140 1150
LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA FNGSWSTKTN

WLFHAMKHY
Length:1,159
Mass (Da):133,936
Last modified:September 11, 2007 - v1
Checksum:i8D8D16AEF6CEFA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601438 Genomic DNA Translation: CAP23732.2

Similar proteinsi

Entry informationi

Entry nameiAGE1_CAEBR
AccessioniPrimary (citable) accession number: P0C5E7
Secondary accession number(s): A8WTC1, Q620C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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