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P0C5E4

- PTPRQ_MOUSE

UniProt

P0C5E4 - PTPRQ_MOUSE

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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene
Ptprq
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells By similarity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2201 – 22011Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  2. hematopoietic progenitor cell differentiation Source: MGI
  3. inner ear morphogenesis Source: MGI
  4. neuromuscular process controlling balance Source: MGI
  5. regulation of fat cell differentiation Source: UniProtKB
  6. vestibular receptor cell morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:Ptprq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1096349. Ptprq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 19061889Extracellular Reviewed predictionAdd
BLAST
Transmembranei1907 – 192721Helical; Reviewed predictionAdd
BLAST
Topological domaini1928 – 2300373Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. stereocilium bundle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show rapid postnatal deterioration in cochlear hair-bundle structure, associated with smaller than normal transducer currents with otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.1 Publication

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 23002283Phosphatidylinositol phosphatase PTPRQPRO_0000302851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi718 – 7181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi731 – 7311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi744 – 7441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi996 – 9961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1008 – 10081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1038 – 10381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1059 – 10591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1249 – 12491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1254 – 12541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1803 – 18031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP0C5E4.

PTM databases

PhosphoSiteiP0C5E4.

Expressioni

Tissue specificityi

In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level).1 Publication

Gene expression databases

BgeeiP0C5E4.
CleanExiMM_PTPRQ.
GenevestigatoriP0C5E4.

Interactioni

Protein-protein interaction databases

BioGridi231884. 9 interactions.
STRINGi10090.ENSMUSP00000058572.

Structurei

3D structure databases

ProteinModelPortaliP0C5E4.
SMRiP0C5E4. Positions 13-191, 268-296, 309-387, 512-1617, 1659-1735, 1983-2296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 15496Fibronectin type-III 1Add
BLAST
Domaini158 – 25396Fibronectin type-III 2Add
BLAST
Domaini309 – 39789Fibronectin type-III 3Add
BLAST
Domaini400 – 49596Fibronectin type-III 4Add
BLAST
Domaini497 – 56468Fibronectin type-III 5Add
BLAST
Domaini568 – 66396Fibronectin type-III 6Add
BLAST
Domaini668 – 75790Fibronectin type-III 7Add
BLAST
Domaini762 – 85291Fibronectin type-III 8Add
BLAST
Domaini857 – 94690Fibronectin type-III 9Add
BLAST
Domaini951 – 1051101Fibronectin type-III 10Add
BLAST
Domaini1056 – 114994Fibronectin type-III 11Add
BLAST
Domaini1154 – 124188Fibronectin type-III 12Add
BLAST
Domaini1246 – 133994Fibronectin type-III 13Add
BLAST
Domaini1343 – 142987Fibronectin type-III 14Add
BLAST
Domaini1433 – 1537105Fibronectin type-III 15Add
BLAST
Domaini1542 – 164099Fibronectin type-III 16Add
BLAST
Domaini1645 – 1746102Fibronectin type-III 17Add
BLAST
Domaini2004 – 2260257Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117483.
HOGENOMiHOG000115793.
HOVERGENiHBG108308.
InParanoidiP0C5E4.
KOiK16910.
OMAiDVELEWE.
OrthoDBiEOG7FXZXD.
PhylomeDBiP0C5E4.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5E4-1 [UniParc]FASTAAdd to Basket

« Hide

MDFLFFFLFS LIGTSESQVD VSGSFDDTVY DITLSSISAT TYSSPVSRTL     50
ATNVSKPGPP VFLAGERVGS AGILLSWNTP PNPNGRIISY VVKYKEVCPW 100
MQTAYTRVRA KPDSLEVLLT NLNPGTTYEI KVAAENSAGI GVFSDPFLFQ 150
TAESAPGKVV NLTVEALNYS AVNLIWYLPR QPNGKITSFK ISVKHARSGI 200
VVKDVSIKVE DLLSGKLPEC NENSDSFLWS TTSPSPTLSR ATPPLRTTHL 250
SNTLARNKIS SVWKEPISFV VTHLRPYTTY LFEVSAVTTE AGYIDSTIVR 300
TPESVPEGPP QNCITGNVTG KAFSISWDPP AIVTGKFSYR VELYGPTGRI 350
LDNSTKDLRF VFTHLTPFTM YDVYVAAETS AGVGPKSNLS VFTPPDVPGA 400
VFDLQIVEVE ATEIRVSWRK PRQPNGIISQ YRVKVSVLES GVILENTLLT 450
GQDEYINNPM TPEIMNLVDP MIGFYEGSGE MSSDLHSLAS FIYNSHPHDF 500
PARTRVEDQR SPVVATRNQY MTDIAAEHLS YVIRRLVPFT EHTISVSAFT 550
VMGEGPPTVL TVRTREQVPS SIQIINYKNI SSSSILLYWD PPEYPNGKIT 600
HYTIYAMELD TNRAFQMTTV DNSFLITGLK KYTRYKMRVA ASTHVGESSL 650
SEENDLFVRT PEDEPESSPQ DVKVTDVSPS ELSLTWSPPE KPNGIIIAYE 700
VFYQNADALF VKNTSTTNIT LSDLKPYTLY NISIQSYTRL GHGNQSSSLL 750
SVRTSETVPD SAPENITYKN ISSEEIEIFF LPPRSPNGII QKYTIYLKRS 800
NSHEARTIET TSLTLTIGGL KKYTHYVIEV SASTLKGEGV RSMPISILTE 850
EDAPDSPPQN FSVKQLSGVT VMLSWQPPLE PNGIILYYTV YVWDKVSLKT 900
INATEVSLEL SDLDYHADYS AYVTASTRFG DGKTRSSVIN FRTPEGEPSD 950
PPKDVHYVNL SSSSIILFWT PPVKPNGIIQ YYSVYYQNTS STFVQNFTLL 1000
EVTQEPGNVT VSARIYKLAV FSYYTFWLTA STLVGNGNKS SDVIHVYTDQ 1050
DIPEGGVGNL TYESLSSTAI NVSWTPPSQP NGLVFYYVSL NLQQSPPRHR 1100
RPPLTTYENS IYFDNLEKYT DYIFKITPST EKGFSETYTA QLHIKTEEDV 1150
PDTPPIINTF KNLSSTSILL SWDPPLKPNG AILSYHLTLQ GTHANRTFVT 1200
SGNHIVLEEL SPFTLYSFLA AARTMKGLGP SSILFFYTDE SAPLAPPQNL 1250
TLINYTSDFV WLTWSPSPLP GGIVKVYSFK IHEHETDTVF YKNISGFQTD 1300
AKLAGLEPVS TYSISVSAFT KVGNGNQFSN VVKFTTQESV PDAVQNIACV 1350
ARDWQSVSVM WDPPRKANGI IIHYMITVEG NSTKVSPRDP MYTFTKLLAN 1400
TSYIFEVRAS TSAGEGNESQ CNVSTLPETV PSVPTNTAFS NVQSTSVTLR 1450
WIKPDTILGY FQNYKITTQL RAQKCREWEP EECVEHQEVQ YLYEANQTED 1500
TVRGLKKFQW YRFQVAASTN AGYGNASSWI STQTLPGPPD GPPENVRVVA 1550
TSPFGINISW NEPAIITGPT FYLIDVKSVD NDNFNISFVK SNEENKTTEI 1600
NDLEVFTRYS VVITAFVGNV SGAYTDGKSS AEVIITTLES VPKDPPNNMT 1650
FQKIPDEVTK FQLSFLPPSQ PNGNIQVYQA LVYREDDPTA VQIHNLSIIQ 1700
KTDTSVIAML EGLKGGHTYN ISVYAINSAG AGPKVQMRIT MDIKAPARPK 1750
TKPIPIHDAT GKLLVTSTTI TIRMPICYYN DDHGPIRNVQ VLVAEAGAQQ 1800
DGNVTKWYDA YFNKARPYFT NEGFPNPPCI EGKTKFSGNE EIYVIGADNA 1850
CMIPGNEEKI CNGPLKPKKQ YLFKFRATNV MGQFTDSEYS DPIKTLGEGL 1900
SERTVEIILS VTLCILSIIL LGTAIFAFAR IRQKQKEGGT YSPRDAEIID 1950
TKFKLDQLIT VADLELKDER LTRLLSYRKS IKPVSKKSFL QHVEELCTNN 2000
NLKFQEEFSE LPKFLQDLSS TDADLPWNRA KNRFPNIKPY NNNRVKLIAD 2050
VSIPGSDYIN ASYVSGYLCP NEFIATQGPL PGTVGDFWRM VWETRAKTLV 2100
MLTQCFEKGR IRCHQYWPED NKPVTVFGDI LITKLMEDIQ IDWTIRDLKI 2150
ERHGDCMTVR QCNFTGWPEH GVPENTTPLI HFVKLVRTSR AHDATPMVVH 2200
CSAGVGRTGV FIALDHLTQH IHDHDFVDIY GLVAELRSER MCMVQNLAQY 2250
IFLHQCILDL LSNKGGHQPV CFVNYSTLQK MDSLDAMEGD VELEWEETTM 2300
Length:2,300
Mass (Da):256,785
Last modified:September 11, 2007 - v1
Checksum:i1866AE48D19FAB09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC021642 Genomic DNA. No translation available.
AC123948 Genomic DNA. No translation available.
AC155168 Genomic DNA. No translation available.
CCDSiCCDS36051.1.
RefSeqiNP_001074901.1. NM_001081432.1.
UniGeneiMm.391418.

Genome annotation databases

EnsembliENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916.
GeneIDi237523.
KEGGimmu:237523.
UCSCiuc007gzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC021642 Genomic DNA. No translation available.
AC123948 Genomic DNA. No translation available.
AC155168 Genomic DNA. No translation available.
CCDSi CCDS36051.1.
RefSeqi NP_001074901.1. NM_001081432.1.
UniGenei Mm.391418.

3D structure databases

ProteinModelPortali P0C5E4.
SMRi P0C5E4. Positions 13-191, 268-296, 309-387, 512-1617, 1659-1735, 1983-2296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231884. 9 interactions.
STRINGi 10090.ENSMUSP00000058572.

PTM databases

PhosphoSitei P0C5E4.

Proteomic databases

PRIDEi P0C5E4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050702 ; ENSMUSP00000058572 ; ENSMUSG00000035916 .
GeneIDi 237523.
KEGGi mmu:237523.
UCSCi uc007gzb.1. mouse.

Organism-specific databases

CTDi 374462.
MGIi MGI:1096349. Ptprq.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117483.
HOGENOMi HOG000115793.
HOVERGENi HBG108308.
InParanoidi P0C5E4.
KOi K16910.
OMAi DVELEWE.
OrthoDBi EOG7FXZXD.
PhylomeDBi P0C5E4.
TreeFami TF351926.

Miscellaneous databases

NextBioi 383394.
PROi P0C5E4.
SOURCEi Search...

Gene expression databases

Bgeei P0C5E4.
CleanExi MM_PTPRQ.
Genevestigatori P0C5E4.

Family and domain databases

Gene3Di 2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles."
    Goodyear R.J., Legan P.K., Wright M.B., Marcotti W., Oganesian A., Coats S.A., Booth C.J., Kros C.J., Seifert R.A., Bowen-Pope D.F., Richardson G.P.
    J. Neurosci. 23:9208-9219(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPTPRQ_MOUSE
AccessioniPrimary (citable) accession number: P0C5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi