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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

Ptprq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity).By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2201Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • inner ear morphogenesis Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • phosphatidylinositol dephosphorylation Source: InterPro
  • regulation of fat cell differentiation Source: UniProtKB
  • vestibular receptor cell morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:Ptprq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1096349. Ptprq.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 1906ExtracellularSequence analysisAdd BLAST1889
Transmembranei1907 – 1927HelicalSequence analysisAdd BLAST21
Topological domaini1928 – 2300CytoplasmicSequence analysisAdd BLAST373

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • stereocilium bundle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show rapid postnatal deterioration in cochlear hair-bundle structure, associated with smaller than normal transducer currents with otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.1 Publication

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000030285118 – 2300Phosphatidylinositol phosphatase PTPRQAdd BLAST2283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi718N-linked (GlcNAc...)Sequence analysis1
Glycosylationi731N-linked (GlcNAc...)Sequence analysis1
Glycosylationi744N-linked (GlcNAc...)Sequence analysis1
Glycosylationi996N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1008N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1038N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1059N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1803N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C5E4.
PeptideAtlasiP0C5E4.
PRIDEiP0C5E4.

PTM databases

iPTMnetiP0C5E4.
PhosphoSitePlusiP0C5E4.

Expressioni

Tissue specificityi

In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000035916.
CleanExiMM_PTPRQ.

Interactioni

Protein-protein interaction databases

BioGridi231884. 9 interactors.
STRINGi10090.ENSMUSP00000058572.

Structurei

3D structure databases

ProteinModelPortaliP0C5E4.
SMRiP0C5E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 154Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini158 – 253Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini309 – 397Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST89
Domaini400 – 495Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini497 – 564Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST68
Domaini568 – 663Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST96
Domaini668 – 757Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini762 – 852Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini857 – 946Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1051Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST101
Domaini1056 – 1149Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST94
Domaini1154 – 1241Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST88
Domaini1246 – 1339Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST94
Domaini1343 – 1429Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST87
Domaini1433 – 1537Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST105
Domaini1542 – 1640Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST99
Domaini1645 – 1746Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST102
Domaini2004 – 2260Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

Contains 17 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115793.
HOVERGENiHBG108308.
InParanoidiP0C5E4.
KOiK16910.
OMAiMVQNLAQ.
OrthoDBiEOG091G0019.
PhylomeDBiP0C5E4.
TreeFamiTF351926.

Family and domain databases

CDDicd00063. FN3. 15 hits.
Gene3Di2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR033045. PTPRQ.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10489:SF414. PTHR10489:SF414. 3 hits.
PfamiPF00041. fn3. 12 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLFFFLFS LIGTSESQVD VSGSFDDTVY DITLSSISAT TYSSPVSRTL
60 70 80 90 100
ATNVSKPGPP VFLAGERVGS AGILLSWNTP PNPNGRIISY VVKYKEVCPW
110 120 130 140 150
MQTAYTRVRA KPDSLEVLLT NLNPGTTYEI KVAAENSAGI GVFSDPFLFQ
160 170 180 190 200
TAESAPGKVV NLTVEALNYS AVNLIWYLPR QPNGKITSFK ISVKHARSGI
210 220 230 240 250
VVKDVSIKVE DLLSGKLPEC NENSDSFLWS TTSPSPTLSR ATPPLRTTHL
260 270 280 290 300
SNTLARNKIS SVWKEPISFV VTHLRPYTTY LFEVSAVTTE AGYIDSTIVR
310 320 330 340 350
TPESVPEGPP QNCITGNVTG KAFSISWDPP AIVTGKFSYR VELYGPTGRI
360 370 380 390 400
LDNSTKDLRF VFTHLTPFTM YDVYVAAETS AGVGPKSNLS VFTPPDVPGA
410 420 430 440 450
VFDLQIVEVE ATEIRVSWRK PRQPNGIISQ YRVKVSVLES GVILENTLLT
460 470 480 490 500
GQDEYINNPM TPEIMNLVDP MIGFYEGSGE MSSDLHSLAS FIYNSHPHDF
510 520 530 540 550
PARTRVEDQR SPVVATRNQY MTDIAAEHLS YVIRRLVPFT EHTISVSAFT
560 570 580 590 600
VMGEGPPTVL TVRTREQVPS SIQIINYKNI SSSSILLYWD PPEYPNGKIT
610 620 630 640 650
HYTIYAMELD TNRAFQMTTV DNSFLITGLK KYTRYKMRVA ASTHVGESSL
660 670 680 690 700
SEENDLFVRT PEDEPESSPQ DVKVTDVSPS ELSLTWSPPE KPNGIIIAYE
710 720 730 740 750
VFYQNADALF VKNTSTTNIT LSDLKPYTLY NISIQSYTRL GHGNQSSSLL
760 770 780 790 800
SVRTSETVPD SAPENITYKN ISSEEIEIFF LPPRSPNGII QKYTIYLKRS
810 820 830 840 850
NSHEARTIET TSLTLTIGGL KKYTHYVIEV SASTLKGEGV RSMPISILTE
860 870 880 890 900
EDAPDSPPQN FSVKQLSGVT VMLSWQPPLE PNGIILYYTV YVWDKVSLKT
910 920 930 940 950
INATEVSLEL SDLDYHADYS AYVTASTRFG DGKTRSSVIN FRTPEGEPSD
960 970 980 990 1000
PPKDVHYVNL SSSSIILFWT PPVKPNGIIQ YYSVYYQNTS STFVQNFTLL
1010 1020 1030 1040 1050
EVTQEPGNVT VSARIYKLAV FSYYTFWLTA STLVGNGNKS SDVIHVYTDQ
1060 1070 1080 1090 1100
DIPEGGVGNL TYESLSSTAI NVSWTPPSQP NGLVFYYVSL NLQQSPPRHR
1110 1120 1130 1140 1150
RPPLTTYENS IYFDNLEKYT DYIFKITPST EKGFSETYTA QLHIKTEEDV
1160 1170 1180 1190 1200
PDTPPIINTF KNLSSTSILL SWDPPLKPNG AILSYHLTLQ GTHANRTFVT
1210 1220 1230 1240 1250
SGNHIVLEEL SPFTLYSFLA AARTMKGLGP SSILFFYTDE SAPLAPPQNL
1260 1270 1280 1290 1300
TLINYTSDFV WLTWSPSPLP GGIVKVYSFK IHEHETDTVF YKNISGFQTD
1310 1320 1330 1340 1350
AKLAGLEPVS TYSISVSAFT KVGNGNQFSN VVKFTTQESV PDAVQNIACV
1360 1370 1380 1390 1400
ARDWQSVSVM WDPPRKANGI IIHYMITVEG NSTKVSPRDP MYTFTKLLAN
1410 1420 1430 1440 1450
TSYIFEVRAS TSAGEGNESQ CNVSTLPETV PSVPTNTAFS NVQSTSVTLR
1460 1470 1480 1490 1500
WIKPDTILGY FQNYKITTQL RAQKCREWEP EECVEHQEVQ YLYEANQTED
1510 1520 1530 1540 1550
TVRGLKKFQW YRFQVAASTN AGYGNASSWI STQTLPGPPD GPPENVRVVA
1560 1570 1580 1590 1600
TSPFGINISW NEPAIITGPT FYLIDVKSVD NDNFNISFVK SNEENKTTEI
1610 1620 1630 1640 1650
NDLEVFTRYS VVITAFVGNV SGAYTDGKSS AEVIITTLES VPKDPPNNMT
1660 1670 1680 1690 1700
FQKIPDEVTK FQLSFLPPSQ PNGNIQVYQA LVYREDDPTA VQIHNLSIIQ
1710 1720 1730 1740 1750
KTDTSVIAML EGLKGGHTYN ISVYAINSAG AGPKVQMRIT MDIKAPARPK
1760 1770 1780 1790 1800
TKPIPIHDAT GKLLVTSTTI TIRMPICYYN DDHGPIRNVQ VLVAEAGAQQ
1810 1820 1830 1840 1850
DGNVTKWYDA YFNKARPYFT NEGFPNPPCI EGKTKFSGNE EIYVIGADNA
1860 1870 1880 1890 1900
CMIPGNEEKI CNGPLKPKKQ YLFKFRATNV MGQFTDSEYS DPIKTLGEGL
1910 1920 1930 1940 1950
SERTVEIILS VTLCILSIIL LGTAIFAFAR IRQKQKEGGT YSPRDAEIID
1960 1970 1980 1990 2000
TKFKLDQLIT VADLELKDER LTRLLSYRKS IKPVSKKSFL QHVEELCTNN
2010 2020 2030 2040 2050
NLKFQEEFSE LPKFLQDLSS TDADLPWNRA KNRFPNIKPY NNNRVKLIAD
2060 2070 2080 2090 2100
VSIPGSDYIN ASYVSGYLCP NEFIATQGPL PGTVGDFWRM VWETRAKTLV
2110 2120 2130 2140 2150
MLTQCFEKGR IRCHQYWPED NKPVTVFGDI LITKLMEDIQ IDWTIRDLKI
2160 2170 2180 2190 2200
ERHGDCMTVR QCNFTGWPEH GVPENTTPLI HFVKLVRTSR AHDATPMVVH
2210 2220 2230 2240 2250
CSAGVGRTGV FIALDHLTQH IHDHDFVDIY GLVAELRSER MCMVQNLAQY
2260 2270 2280 2290 2300
IFLHQCILDL LSNKGGHQPV CFVNYSTLQK MDSLDAMEGD VELEWEETTM
Length:2,300
Mass (Da):256,785
Last modified:September 11, 2007 - v1
Checksum:i1866AE48D19FAB09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021642 Genomic DNA. No translation available.
AC123948 Genomic DNA. No translation available.
AC155168 Genomic DNA. No translation available.
CCDSiCCDS36051.1.
RefSeqiNP_001074901.1. NM_001081432.1.
UniGeneiMm.391418.

Genome annotation databases

EnsembliENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916.
GeneIDi237523.
KEGGimmu:237523.
UCSCiuc007gzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021642 Genomic DNA. No translation available.
AC123948 Genomic DNA. No translation available.
AC155168 Genomic DNA. No translation available.
CCDSiCCDS36051.1.
RefSeqiNP_001074901.1. NM_001081432.1.
UniGeneiMm.391418.

3D structure databases

ProteinModelPortaliP0C5E4.
SMRiP0C5E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231884. 9 interactors.
STRINGi10090.ENSMUSP00000058572.

PTM databases

iPTMnetiP0C5E4.
PhosphoSitePlusiP0C5E4.

Proteomic databases

PaxDbiP0C5E4.
PeptideAtlasiP0C5E4.
PRIDEiP0C5E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916.
GeneIDi237523.
KEGGimmu:237523.
UCSCiuc007gzb.1. mouse.

Organism-specific databases

CTDi374462.
MGIiMGI:1096349. Ptprq.

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115793.
HOVERGENiHBG108308.
InParanoidiP0C5E4.
KOiK16910.
OMAiMVQNLAQ.
OrthoDBiEOG091G0019.
PhylomeDBiP0C5E4.
TreeFamiTF351926.

Miscellaneous databases

PROiP0C5E4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035916.
CleanExiMM_PTPRQ.

Family and domain databases

CDDicd00063. FN3. 15 hits.
Gene3Di2.60.40.10. 18 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR033045. PTPRQ.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10489:SF414. PTHR10489:SF414. 3 hits.
PfamiPF00041. fn3. 12 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 16 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 16 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRQ_MOUSE
AccessioniPrimary (citable) accession number: P0C5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.