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P0C5E4

- PTPRQ_MOUSE

UniProt

P0C5E4 - PTPRQ_MOUSE

Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

Ptprq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2201 – 22011Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
    2. hematopoietic progenitor cell differentiation Source: MGI
    3. inner ear morphogenesis Source: MGI
    4. neuromuscular process controlling balance Source: MGI
    5. regulation of fat cell differentiation Source: UniProtKB
    6. vestibular receptor cell morphogenesis Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
    Alternative name(s):
    Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
    Short name:
    PTP-RQ
    Short name:
    R-PTP-Q
    Gene namesi
    Name:Ptprq
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1096349. Ptprq.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. stereocilium bundle Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice show rapid postnatal deterioration in cochlear hair-bundle structure, associated with smaller than normal transducer currents with otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.1 Publication

    Keywords - Diseasei

    Deafness

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 23002283Phosphatidylinositol phosphatase PTPRQPRO_0000302851Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi744 – 7441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi996 – 9961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1008 – 10081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1038 – 10381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1059 – 10591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1249 – 12491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1254 – 12541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1803 – 18031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP0C5E4.

    PTM databases

    PhosphoSiteiP0C5E4.

    Expressioni

    Tissue specificityi

    In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level).1 Publication

    Gene expression databases

    BgeeiP0C5E4.
    CleanExiMM_PTPRQ.
    GenevestigatoriP0C5E4.

    Interactioni

    Protein-protein interaction databases

    BioGridi231884. 9 interactions.
    STRINGi10090.ENSMUSP00000058572.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C5E4.
    SMRiP0C5E4. Positions 13-191, 268-296, 309-387, 512-1617, 1659-1735, 1983-2296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 19061889ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1928 – 2300373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1907 – 192721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 15496Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini158 – 25396Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini309 – 39789Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 49596Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini497 – 56468Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini568 – 66396Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini668 – 75790Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini762 – 85291Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini857 – 94690Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini951 – 1051101Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1056 – 114994Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1154 – 124188Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1246 – 133994Fibronectin type-III 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1343 – 142987Fibronectin type-III 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1433 – 1537105Fibronectin type-III 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1542 – 164099Fibronectin type-III 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1645 – 1746102Fibronectin type-III 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini2004 – 2260257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 17 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117483.
    HOGENOMiHOG000115793.
    HOVERGENiHBG108308.
    InParanoidiP0C5E4.
    KOiK16910.
    OMAiDVELEWE.
    OrthoDBiEOG7FXZXD.
    PhylomeDBiP0C5E4.
    TreeFamiTF351926.

    Family and domain databases

    Gene3Di2.60.40.10. 18 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 16 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50853. FN3. 16 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C5E4-1 [UniParc]FASTAAdd to Basket

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    MDFLFFFLFS LIGTSESQVD VSGSFDDTVY DITLSSISAT TYSSPVSRTL     50
    ATNVSKPGPP VFLAGERVGS AGILLSWNTP PNPNGRIISY VVKYKEVCPW 100
    MQTAYTRVRA KPDSLEVLLT NLNPGTTYEI KVAAENSAGI GVFSDPFLFQ 150
    TAESAPGKVV NLTVEALNYS AVNLIWYLPR QPNGKITSFK ISVKHARSGI 200
    VVKDVSIKVE DLLSGKLPEC NENSDSFLWS TTSPSPTLSR ATPPLRTTHL 250
    SNTLARNKIS SVWKEPISFV VTHLRPYTTY LFEVSAVTTE AGYIDSTIVR 300
    TPESVPEGPP QNCITGNVTG KAFSISWDPP AIVTGKFSYR VELYGPTGRI 350
    LDNSTKDLRF VFTHLTPFTM YDVYVAAETS AGVGPKSNLS VFTPPDVPGA 400
    VFDLQIVEVE ATEIRVSWRK PRQPNGIISQ YRVKVSVLES GVILENTLLT 450
    GQDEYINNPM TPEIMNLVDP MIGFYEGSGE MSSDLHSLAS FIYNSHPHDF 500
    PARTRVEDQR SPVVATRNQY MTDIAAEHLS YVIRRLVPFT EHTISVSAFT 550
    VMGEGPPTVL TVRTREQVPS SIQIINYKNI SSSSILLYWD PPEYPNGKIT 600
    HYTIYAMELD TNRAFQMTTV DNSFLITGLK KYTRYKMRVA ASTHVGESSL 650
    SEENDLFVRT PEDEPESSPQ DVKVTDVSPS ELSLTWSPPE KPNGIIIAYE 700
    VFYQNADALF VKNTSTTNIT LSDLKPYTLY NISIQSYTRL GHGNQSSSLL 750
    SVRTSETVPD SAPENITYKN ISSEEIEIFF LPPRSPNGII QKYTIYLKRS 800
    NSHEARTIET TSLTLTIGGL KKYTHYVIEV SASTLKGEGV RSMPISILTE 850
    EDAPDSPPQN FSVKQLSGVT VMLSWQPPLE PNGIILYYTV YVWDKVSLKT 900
    INATEVSLEL SDLDYHADYS AYVTASTRFG DGKTRSSVIN FRTPEGEPSD 950
    PPKDVHYVNL SSSSIILFWT PPVKPNGIIQ YYSVYYQNTS STFVQNFTLL 1000
    EVTQEPGNVT VSARIYKLAV FSYYTFWLTA STLVGNGNKS SDVIHVYTDQ 1050
    DIPEGGVGNL TYESLSSTAI NVSWTPPSQP NGLVFYYVSL NLQQSPPRHR 1100
    RPPLTTYENS IYFDNLEKYT DYIFKITPST EKGFSETYTA QLHIKTEEDV 1150
    PDTPPIINTF KNLSSTSILL SWDPPLKPNG AILSYHLTLQ GTHANRTFVT 1200
    SGNHIVLEEL SPFTLYSFLA AARTMKGLGP SSILFFYTDE SAPLAPPQNL 1250
    TLINYTSDFV WLTWSPSPLP GGIVKVYSFK IHEHETDTVF YKNISGFQTD 1300
    AKLAGLEPVS TYSISVSAFT KVGNGNQFSN VVKFTTQESV PDAVQNIACV 1350
    ARDWQSVSVM WDPPRKANGI IIHYMITVEG NSTKVSPRDP MYTFTKLLAN 1400
    TSYIFEVRAS TSAGEGNESQ CNVSTLPETV PSVPTNTAFS NVQSTSVTLR 1450
    WIKPDTILGY FQNYKITTQL RAQKCREWEP EECVEHQEVQ YLYEANQTED 1500
    TVRGLKKFQW YRFQVAASTN AGYGNASSWI STQTLPGPPD GPPENVRVVA 1550
    TSPFGINISW NEPAIITGPT FYLIDVKSVD NDNFNISFVK SNEENKTTEI 1600
    NDLEVFTRYS VVITAFVGNV SGAYTDGKSS AEVIITTLES VPKDPPNNMT 1650
    FQKIPDEVTK FQLSFLPPSQ PNGNIQVYQA LVYREDDPTA VQIHNLSIIQ 1700
    KTDTSVIAML EGLKGGHTYN ISVYAINSAG AGPKVQMRIT MDIKAPARPK 1750
    TKPIPIHDAT GKLLVTSTTI TIRMPICYYN DDHGPIRNVQ VLVAEAGAQQ 1800
    DGNVTKWYDA YFNKARPYFT NEGFPNPPCI EGKTKFSGNE EIYVIGADNA 1850
    CMIPGNEEKI CNGPLKPKKQ YLFKFRATNV MGQFTDSEYS DPIKTLGEGL 1900
    SERTVEIILS VTLCILSIIL LGTAIFAFAR IRQKQKEGGT YSPRDAEIID 1950
    TKFKLDQLIT VADLELKDER LTRLLSYRKS IKPVSKKSFL QHVEELCTNN 2000
    NLKFQEEFSE LPKFLQDLSS TDADLPWNRA KNRFPNIKPY NNNRVKLIAD 2050
    VSIPGSDYIN ASYVSGYLCP NEFIATQGPL PGTVGDFWRM VWETRAKTLV 2100
    MLTQCFEKGR IRCHQYWPED NKPVTVFGDI LITKLMEDIQ IDWTIRDLKI 2150
    ERHGDCMTVR QCNFTGWPEH GVPENTTPLI HFVKLVRTSR AHDATPMVVH 2200
    CSAGVGRTGV FIALDHLTQH IHDHDFVDIY GLVAELRSER MCMVQNLAQY 2250
    IFLHQCILDL LSNKGGHQPV CFVNYSTLQK MDSLDAMEGD VELEWEETTM 2300
    Length:2,300
    Mass (Da):256,785
    Last modified:September 11, 2007 - v1
    Checksum:i1866AE48D19FAB09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC021642 Genomic DNA. No translation available.
    AC123948 Genomic DNA. No translation available.
    AC155168 Genomic DNA. No translation available.
    CCDSiCCDS36051.1.
    RefSeqiNP_001074901.1. NM_001081432.1.
    UniGeneiMm.391418.

    Genome annotation databases

    EnsembliENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916.
    GeneIDi237523.
    KEGGimmu:237523.
    UCSCiuc007gzb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC021642 Genomic DNA. No translation available.
    AC123948 Genomic DNA. No translation available.
    AC155168 Genomic DNA. No translation available.
    CCDSi CCDS36051.1.
    RefSeqi NP_001074901.1. NM_001081432.1.
    UniGenei Mm.391418.

    3D structure databases

    ProteinModelPortali P0C5E4.
    SMRi P0C5E4. Positions 13-191, 268-296, 309-387, 512-1617, 1659-1735, 1983-2296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231884. 9 interactions.
    STRINGi 10090.ENSMUSP00000058572.

    PTM databases

    PhosphoSitei P0C5E4.

    Proteomic databases

    PRIDEi P0C5E4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050702 ; ENSMUSP00000058572 ; ENSMUSG00000035916 .
    GeneIDi 237523.
    KEGGi mmu:237523.
    UCSCi uc007gzb.1. mouse.

    Organism-specific databases

    CTDi 374462.
    MGIi MGI:1096349. Ptprq.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117483.
    HOGENOMi HOG000115793.
    HOVERGENi HBG108308.
    InParanoidi P0C5E4.
    KOi K16910.
    OMAi DVELEWE.
    OrthoDBi EOG7FXZXD.
    PhylomeDBi P0C5E4.
    TreeFami TF351926.

    Miscellaneous databases

    NextBioi 383394.
    PROi P0C5E4.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C5E4.
    CleanExi MM_PTPRQ.
    Genevestigatori P0C5E4.

    Family and domain databases

    Gene3Di 2.60.40.10. 18 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 16 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50853. FN3. 16 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles."
      Goodyear R.J., Legan P.K., Wright M.B., Marcotti W., Oganesian A., Coats S.A., Booth C.J., Kros C.J., Seifert R.A., Bowen-Pope D.F., Richardson G.P.
      J. Neurosci. 23:9208-9219(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPTPRQ_MOUSE
    AccessioniPrimary (citable) accession number: P0C5E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3