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Protein

Riboflavin kinase

Gene

FMN1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (FMN1)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Magnesium or zincBy similarity1
Active sitei140NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavin mononucleotide kinase 1
Gene namesi
Name:FMN1
ORF Names:CHGG_09149.2
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018391 – 235Riboflavin kinaseAdd BLAST235

Proteomic databases

PRIDEiP0C5D9

Interactioni

Protein-protein interaction databases

STRINGi306901.XP_001227076.1

Structurei

3D structure databases

ProteinModelPortaliP0C5D9
SMRiP0C5D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 98Poly-AlaAdd BLAST13

Sequence similaritiesi

Belongs to the flavokinase family.Curated

Phylogenomic databases

eggNOGiKOG3110 Eukaryota
KOG4039 Eukaryota
COG0196 LUCA
COG0702 LUCA
InParanoidiP0C5D9
OrthoDBiEOG092C5F1Q

Family and domain databases

Gene3Di2.40.30.30, 1 hit
InterProiView protein in InterPro
IPR023468 Riboflavin_kinase
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF01687 Flavokinase, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 2 hits

Sequencei

Sequence statusi: Complete.

P0C5D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQPPNRPP LIGDPSGPAP PYPFRMSGLV ISGFGRGSKE LGIPTANLPV
60 70 80 90 100
DDAQTPWISS IPSGVYFGWA SLNLPASHPD SLTSSAAAAA AAAAAAAAPG
110 120 130 140 150
EDGGGAGEQR QRGGNGFAVY PMVMSIGYNP FYKNTVRSAE VHVLHRFGAD
160 170 180 190 200
FYGVEMRLLI AGFIREEKDY SGLEALIADI EFDCEVAKRS LAREGWAPSG
210 220 230
VDVEVDVPGE GVKVLRGSLE CGWLIRPDEL GEGGK
Length:235
Mass (Da):24,680
Last modified:September 11, 2007 - v1
Checksum:i90586511CDB868EF
GO

Sequence cautioni

The sequence EAQ85135 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene CHGG_09149 has been split into 2 genes: CHGG_09149.1 and CHGG_09149.2.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408034 Genomic DNA Translation: EAQ85135.1 Sequence problems.
RefSeqiXP_001227076.1, XM_001227075.1

Genome annotation databases

EnsemblFungiiEAQ85135; EAQ85135; CHGG_09149
GeneIDi4395860

Similar proteinsi

Entry informationi

Entry nameiRIFK_CHAGB
AccessioniPrimary (citable) accession number: P0C5D9
Secondary accession number(s): Q2GSA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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