P0C5D9 (RIFK_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin kinase
EC=2.7.1.26

Alternative name(s):
Flavin mononucleotide kinase 1

Gene names

Name:	FMN1
ORF Names:	CHGG_09149.2

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium › Chaetomium globosum

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme By similarity.
Catalytic activity	ATP + riboflavin = ADP + FMN.
Cofactor	Zinc or magnesium By similarity.
Pathway	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.
Sequence similarities	Belongs to the flavokinase family.
Sequence caution	The sequence EAQ85135.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene CHGG_09149 has been split into 2 genes: CHGG_09149.1 and CHGG_09149.2.

Ontologies

Keywords
Ligand	ATP-binding FMN Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	FMN biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway riboflavin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW riboflavin kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Riboflavin kinase		PRO_0000301839
Regions
	Compositional bias	86 – 98	13	Poly-Ala
Sites
	Active site	140	1	Nucleophile By similarity
	Metal binding	45	1	Magnesium or zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C5D9 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 90586511CDB868EF	FASTA	235	24,680
	10 20 30 40 50 60 MAHQPPNRPP LIGDPSGPAP PYPFRMSGLV ISGFGRGSKE LGIPTANLPV DDAQTPWISS 70 80 90 100 110 120 IPSGVYFGWA SLNLPASHPD SLTSSAAAAA AAAAAAAAPG EDGGGAGEQR QRGGNGFAVY 130 140 150 160 170 180 PMVMSIGYNP FYKNTVRSAE VHVLHRFGAD FYGVEMRLLI AGFIREEKDY SGLEALIADI 190 200 210 220 230 EFDCEVAKRS LAREGWAPSG VDVEVDVPGE GVKVLRGSLE CGWLIRPDEL GEGGK

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." The Broad Institute Genome Sequencing Platform Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408034 Genomic DNA. Translation: EAQ85135.1. Sequence problems.
RefSeq	XP_001227076.1. XM_001227075.1.
3D structure databases
ProteinModelPortal	P0C5D9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4395860.
Phylogenomic databases
OrthoDB	EOG4BCHXC.
Enzyme and pathway databases
UniPathway	UPA00276; UER00406.
Family and domain databases
Gene3D	2.40.30.30. 2 hits.
InterPro	IPR023468. Riboflavin_kinase. IPR015865. Riboflavin_kinase_bac/euk. IPR023465. Riboflavin_kinase_domain. [Graphical view]
PANTHER	PTHR22749. PTHR22749. 1 hit.
Pfam	PF01687. Flavokinase. 1 hit. [Graphical view]
SMART	SM00904. Flavokinase. 1 hit. [Graphical view]
SUPFAM	SSF82114. Riboflavin_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIFK_CHAGB

Accession

Primary (citable) accession number: P0C5D9
Secondary accession number(s): Q2GSA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	March 6, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program