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Protein

Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunit

Gene

PP2A4

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Manganese 1By similarity
Metal bindingi65 – 651Manganese 1By similarity
Metal bindingi91 – 911Manganese 1By similarity
Metal bindingi91 – 911Manganese 2By similarity
Metal bindingi123 – 1231Manganese 2By similarity
Active sitei124 – 1241Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi247 – 2471Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A4
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiP0C5D7.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunitPRO_0000301658Add
BLAST

Proteomic databases

PRIDEiP0C5D7.

Structurei

3D structure databases

ProteinModelPortaliP0C5D7.
SMRiP0C5D7. Positions 16-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696.
OMAiHISRARC.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C5D7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEESVGSRGG SGGGGLDAQI EQLMECRPLS ETEVKTLCEK AKEILMEESN
60 70 80 90 100
VQPVKSPVTI CGDIHGQFHD LVELFRIGGK CPDTNYLFMG DYVDRGYYSV
110 120 130 140 150
ETVTLLVALK VRYPQRITIL RGNHESRQIT QVYGFYDECL RKYGSANVWK
160 170 180 190 200
IFTDLFDYFP LTALVESEIF CLHGGLSPSI DNLDSVRSLD RVQEVPHEGP
210 220 230 240 250
MCDLLWSDPD DRCGWGISPR GAGYTFGQDI SEQFNHSNNL KLVARAHQLV
260 270 280 290 300
MEGYNWAHEQ KVVTIFSAPN YCYRCGNMAS ILEVDDCRNH TFIQFEPAPR
310
RGEPDVTRRT PDYFL
Length:315
Mass (Da):35,702
Last modified:September 11, 2007 - v1
Checksum:i16C878B644231454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173881 Genomic DNA. Translation: AAD48068.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173881 Genomic DNA. Translation: AAD48068.1.

3D structure databases

ProteinModelPortaliP0C5D7.
SMRiP0C5D7. Positions 16-315.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0C5D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GrameneiP0C5D7.

Phylogenomic databases

HOGENOMiHOG000172696.
OMAiHISRARC.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of protein phosphatase 2A catalytic subunit genes from Oryza sativa."
    Yu R.M.K., Kong R.Y.C.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. IR36.

Entry informationi

Entry nameiPP2A4_ORYSI
AccessioniPrimary (citable) accession number: P0C5D7
Secondary accession number(s): Q0IXS3, Q338E3, Q9SBW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: January 7, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.