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Protein

Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunit

Gene

PP2A4

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Manganese 1By similarity1
Metal bindingi65Manganese 1By similarity1
Metal bindingi91Manganese 1By similarity1
Metal bindingi91Manganese 2By similarity1
Metal bindingi123Manganese 2By similarity1
Active sitei124Proton donorBy similarity1
Metal bindingi173Manganese 2By similarity1
Metal bindingi247Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-OSA-198753 ERK/MAPK targets
R-OSA-202670 ERKs are inactivated
R-OSA-69231 Cyclin D associated events in G1
R-OSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-OSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A4
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003016581 – 315Putative serine/threonine-protein phosphatase PP2A-4 catalytic subunitAdd BLAST315

Proteomic databases

PRIDEiP0C5D7

Expressioni

Gene expression databases

ExpressionAtlasiP0C5D7 differential

Structurei

3D structure databases

ProteinModelPortaliP0C5D7
SMRiP0C5D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
HOGENOMiHOG000172696
OMAiREHITIL
OrthoDBiEOG09360EXD

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESVGSRGG SGGGGLDAQI EQLMECRPLS ETEVKTLCEK AKEILMEESN
60 70 80 90 100
VQPVKSPVTI CGDIHGQFHD LVELFRIGGK CPDTNYLFMG DYVDRGYYSV
110 120 130 140 150
ETVTLLVALK VRYPQRITIL RGNHESRQIT QVYGFYDECL RKYGSANVWK
160 170 180 190 200
IFTDLFDYFP LTALVESEIF CLHGGLSPSI DNLDSVRSLD RVQEVPHEGP
210 220 230 240 250
MCDLLWSDPD DRCGWGISPR GAGYTFGQDI SEQFNHSNNL KLVARAHQLV
260 270 280 290 300
MEGYNWAHEQ KVVTIFSAPN YCYRCGNMAS ILEVDDCRNH TFIQFEPAPR
310
RGEPDVTRRT PDYFL
Length:315
Mass (Da):35,702
Last modified:September 11, 2007 - v1
Checksum:i16C878B644231454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173881 Genomic DNA Translation: AAD48068.1

Genome annotation databases

EnsemblPlantsiBGIOSGA040481-TA; BGIOSGA040481-PA; BGIOSGA040481
GrameneiBGIOSGA040481-TA; BGIOSGA040481-PA; BGIOSGA040481

Similar proteinsi

Entry informationi

Entry nameiPP2A4_ORYSI
AccessioniPrimary (citable) accession number: P0C5D7
Secondary accession number(s): Q0IXS3, Q338E3, Q9SBW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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