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P0C5C1 (BLAC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-lactamase
EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:blaA
Synonyms:blaC
Ordered Locus Names:Rv2068c, MT2128
ORF Names:MTCY49.07c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Cell membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 307284Beta-lactamase
PRO_0000017005

Regions

Region250 – 2523Substrate binding By similarity

Sites

Active site841Acyl-ester intermediate By similarity

Amino acid modifications

Lipidation241N-palmitoyl cysteine Potential
Lipidation241S-diacylglycerol cysteine Potential

Secondary structure

1 .................................................. 307
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C5C1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 448CB2A0E05F4315

FASTA30732,568
        10         20         30         40         50         60 
MRNRGFGRRE LLVAMAMLVS VTGCARHASG ARPASTTLPA GADLADRFAE LERRYDARLG 

        70         80         90        100        110        120 
VYVPATGTTA AIEYRADERF AFCSTFKAPL VAAVLHQNPL THLDKLITYT SDDIRSISPV 

       130        140        150        160        170        180 
AQQHVQTGMT IGQLCDAAIR YSDGTAANLL LADLGGPGGG TAAFTGYLRS LGDTVSRLDA 

       190        200        210        220        230        240 
EEPELNRDPP GDERDTTTPH AIALVLQQLV LGNALPPDKR ALLTDWMARN TTGAKRIRAG 

       250        260        270        280        290        300 
FPADWKVIDK TGTGDYGRAN DIAVVWSPTG VPYVVAVMSD RAGGGYDAEP REALLAEAAT 


CVAGVLA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842578 Genomic DNA. Translation: CAA98216.1.
AE000516 Genomic DNA. Translation: AAK46408.1.
AL123456 Genomic DNA. Translation: CCP44842.1.
PIRG70764.
RefSeqNP_216584.1. NC_000962.3.
NP_336594.1. NC_002755.2.
YP_006515481.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GDNX-ray1.72A41-307[»]
3CG5X-ray1.70A43-307[»]
3IQAX-ray2.20A43-307[»]
3M6BX-ray1.30A43-307[»]
3M6HX-ray1.99A43-307[»]
3N6IX-ray2.00A43-307[»]
3N7WX-ray1.70A43-307[»]
3N8LX-ray1.40A43-307[»]
3N8RX-ray1.41A43-307[»]
3N8SX-ray2.00A43-307[»]
3NBLX-ray2.00A43-307[»]
3NC8X-ray1.50A43-307[»]
3NCKX-ray2.80A43-307[»]
3NDEX-ray1.70A43-307[»]
3NDGX-ray1.90A43-307[»]
3NY4X-ray1.22A43-307[»]
3VFFX-ray2.78A/B/C/D43-307[»]
3VFHX-ray2.57A/B/C/D43-307[»]
4DF6X-ray2.29A43-307[»]
ProteinModelPortalP0C5C1.
SMRP0C5C1. Positions 43-307.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2068c.

Proteomic databases

PRIDEP0C5C1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46408; AAK46408; MT2128.
GeneID13316872.
888742.
924602.
KEGGmtc:MT2128.
mtu:Rv2068c.
mtv:RVBD_2068c.
PATRIC18126442. VBIMycTub22151_2334.

Organism-specific databases

TubercuListRv2068c.

Phylogenomic databases

eggNOGCOG2367.
HOGENOMHOG000201073.
KOK01467.
OMAEYGRAND.
ProtClustDBCLSK791603.

Enzyme and pathway databases

SABIO-RKP0C5C1.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0C5C1.

Entry information

Entry nameBLAC_MYCTU
AccessionPrimary (citable) accession number: P0C5C1
Secondary accession number(s): L0T8I9, P0A5I6, Q10670
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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