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P0C5C1 (BLAC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-lactamase
EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:blaA
Synonyms:blaC
Ordered Locus Names:Rv2068c, MT2128
ORF Names:MTCY49.07c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Cell membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionHydrolase
   PTMLipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processbeta-lactam antibiotic catabolic process

Inferred from mutant phenotype. Source: MTBBASE

response to antibiotic

Inferred from mutant phenotype. Source: MTBBASE

   Cellular componentextracellular region

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functioncephalosporinase activity

Inferred from direct assay. Source: MTBBASE

penicillinase activity

Inferred from direct assay. Source: MTBBASE

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 307284Beta-lactamase
PRO_0000017005

Regions

Region250 – 2523Substrate binding By similarity

Sites

Active site841Acyl-ester intermediate By similarity

Amino acid modifications

Lipidation241N-palmitoyl cysteine Potential
Lipidation241S-diacylglycerol cysteine Potential

Secondary structure

1 ................................................ 307
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C5C1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 448CB2A0E05F4315

FASTA30732,568
        10         20         30         40         50         60 
MRNRGFGRRE LLVAMAMLVS VTGCARHASG ARPASTTLPA GADLADRFAE LERRYDARLG 

        70         80         90        100        110        120 
VYVPATGTTA AIEYRADERF AFCSTFKAPL VAAVLHQNPL THLDKLITYT SDDIRSISPV 

       130        140        150        160        170        180 
AQQHVQTGMT IGQLCDAAIR YSDGTAANLL LADLGGPGGG TAAFTGYLRS LGDTVSRLDA 

       190        200        210        220        230        240 
EEPELNRDPP GDERDTTTPH AIALVLQQLV LGNALPPDKR ALLTDWMARN TTGAKRIRAG 

       250        260        270        280        290        300 
FPADWKVIDK TGTGDYGRAN DIAVVWSPTG VPYVVAVMSD RAGGGYDAEP REALLAEAAT 


CVAGVLA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842578 Genomic DNA. Translation: CAA98216.1.
AE000516 Genomic DNA. Translation: AAK46408.1.
PIRG70764.
RefSeqNP_216584.1. NC_000962.2.
NP_336594.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GDNX-ray1.72A41-307[»]
3CG5X-ray1.70A43-307[»]
3IQAX-ray2.20A43-307[»]
3M6BX-ray1.30A43-307[»]
3M6HX-ray1.99A43-307[»]
3N8SX-ray2.00A43-307[»]
3NY4X-ray1.22A43-307[»]
ProteinModelPortalP0C5C1.
SMRP0C5C1. Positions 43-307.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001641; EBMYCP00000001641; EBMYCG00000001640.
EBMYCT00000070954; EBMYCP00000069013; EBMYCG00000070949.
GeneID888742.
924602.
GenomeReviewsGene locus MT2128 in contig AE000516_GR.
Gene locus Rv2068c in contig AL123456_GR.
KEGGmtc:MT2128.
mtu:Rv2068c.
PATRIC18126442. VBIMycTub22151_2334.
TIGRMT2128.

Organism-specific databases

TubercuListRv2068c.

Phylogenomic databases

GeneTreeEBGT00050000016522.
HOGENOMHBG535713.
OMAEYGRAND.
PhylomeDBP0C5C1.
ProtClustDBCLSK791603.

Family and domain databases

InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
Gene3DG3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.
KOK01467.
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_MYCTU
AccessionPrimary (citable) accession number: P0C5C1
Secondary accession number(s): P0A5I6, Q10670
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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