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P0C5A3 (DPNP_ORYSA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3'(2'),5'-bisphosphate nucleotidase
EC=3.1.3.7
Alternative name(s):
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
DPNPase
OrganismOryza sativa (Rice)
Taxonomic identifier4530 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS.

Catalytic activity

Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.

Cofactor

Magnesium.

Enzyme regulation

Inhibited by Ca2+, Li+, and Na+ and activated by K+.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processsulfur compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular function3'(2'),5'-bisphosphate nucleotidase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3583583'(2'),5'-bisphosphate nucleotidase
PRO_0000296248

Regions

Region142 – 1454Substrate binding By similarity

Sites

Metal binding781Magnesium 1 By similarity
Metal binding1401Magnesium 1 By similarity
Metal binding1401Magnesium 2 By similarity
Metal binding1421Magnesium 1; via carbonyl oxygen By similarity
Metal binding1431Magnesium 2 By similarity
Metal binding2921Magnesium 2 By similarity
Binding site781Substrate By similarity
Binding site2921Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C5A3 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: EFE813C18BEDB5FD

FASTA35837,480
        10         20         30         40         50         60 
MSQAAGNPYA AELAAAKKAV TLAARLCQAV QKDILQSGVQ SKADQSPVTV ADYGSQILVS 

        70         80         90        100        110        120 
LVLKMEAPAS SSFSMVAEED SEELRKEGAE EILENITELV NETIVDDGTY SIYFSKEGIL 

       130        140        150        160        170        180 
SAIDDGKSEG GPSGRHWVLD PIDGTKGFLR GDQYAIALAL LDEGKVVLGV LACPNLSLGS 

       190        200        210        220        230        240 
IGNLNGGSSG DQVGALFSAT IGCGAEVESL QGSPAQKISV CSIDNPVEAS FFESYEGAHS 

       250        260        270        280        290        300 
LRDLTGSIAE KLGVQAPPVR IDSQAKYGAL ARGDGAIYLR FPHKGYREKI WDHAAGSIVV 

       310        320        330        340        350 
TEAGGLVTDA SGNDLDFSKG RFLDLDTGII ATNKQLMPSL LKAVQDAIKE QNQAASPL

« Hide

References

[1]"A rice HAL2-like gene encodes a Ca(2+)-sensitive 3'(2'),5'-diphosphonucleoside 3'(2')-phosphohydrolase and complements yeast met22 and Escherichia coli cysQ mutations."
Peng Z., Verma D.P.S.
J. Biol. Chem. 270:29105-29110(1995) [PubMed: 7493934] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Tallahamsa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U33283 mRNA. Translation: AAC49121.1.
PIRT03305.

3D structure databases

ProteinModelPortalP0C5A3.
ModBaseSearch...

Proteomic databases

PRIDEP0C5A3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os12g08280.1; LOC_Os12g08280.1; LOC_Os12g08280.

Organism-specific databases

GrameneQ40639.

Gene expression databases

GenevestigatorP0C5A3.

Family and domain databases

InterProIPR006239. Bisphos_HAL2.
IPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
TIGRFAMsTIGR01330. Bisphos_HAL2. 1 hit.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPNP_ORYSA
AccessionPrimary (citable) accession number: P0C5A3
Secondary accession number(s): Q40639
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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