Reviewed, UniProtKB/Swiss-Prot P0C599 (DUPD1_TAKRU)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

dupd1

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Dual specificity phosphatase DUPD1		PRO_0000295886
Regions
	Domain	46 – 193	148	Tyrosine-protein phosphatase
Sites
	Active site	139	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C599-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 940C87A022441CF0	FASTA	210	23,702
	10 20 30 40 50 60 MSSVVKSKSK NPYAAVRVDP DSDYITPGTL DLEQLFWSGP GVQYTHVNQV WPGIYIGDEK 70 80 90 100 110 120 TALERPGLRD LGITHVLNAA EGKWNNVLTG ADYYSDTNIQ YYGIEADDKP TFNISQFFHP 130 140 150 160 170 180 AAQFIHEALS QPHNVLVHCV MGRSRSATLV LAYLMMEHSL SVVDAIEHVR QRRCILPNHG 190 200 210 FLKQLRALDI TLQEARLKQK TQTQGQEKPR

References

[1]

"Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes." Aparicio S., Chapman J., Stupka E., Putnam N., Chia J.M., Dehal P., Christoffels A., Rash S., Hoon S., Smit A., Gelpke M.D., Roach J., Oh T., Ho I.Y., Wong M., Detter C., Verhoef F., Predki P. , Tay A., Lucas S., Richardson P., Smith S.F., Clark M.S., Edwards Y.J., Doggett N., Zharkikh A., Tavtigian S.V., Pruss D., Barnstead M., Evans C., Baden H., Powell J., Glusman G., Rowen L., Hood L., Tan Y.H., Elgar G., Hawkins T., Venkatesh B., Rokhsar D., Brenner S. Science 297:1301-1310(2002) [PubMed: 12142439] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAB01002848 Genomic DNA. No translation available.
3D structure databases
SMR	P0C599. Positions 31-194.
ModBase	Search...
Genome annotation databases
Ensembl	ENSTRUT00000037785; ENSTRUP00000037650; ENSTRUG00000014727; Takifugu rubripes. [Genome view]
Phylogenomic databases
eggNOG	veNOG15113.
InParanoid	P0C599.
Enzyme and pathway databases
BRENDA	3.1.3.16. 281122. 3.1.3.48. 281122.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_TAKRU

Accession

Primary (citable) accession number: P0C599

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	January 19, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)