Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiAnolis carolinensis (Green anole) (American chameleon)
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958841 – 217Dual specificity phosphatase DUPD1Add BLAST217

Proteomic databases

PRIDEiP0C598

Interactioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000008506

Structurei

3D structure databases

ProteinModelPortaliP0C598
SMRiP0C598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 193Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 145Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiP0C598

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P0C598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTALKSGK ISAYAAVKVD PDGDYCTPGA FDLERLFWKG SPKYTHVNEV
60 70 80 90 100
WPNLYIGDEK TALDRYSLEK AGFTHILNAA HGRWNVDTGP EYYSDMNIEY
110 120 130 140 150
HGVEADDLPT FNLSPFFYSA AEFIHTALQN ETSKILVHCA MGRSRSAALV
160 170 180 190 200
LAYLMIYKNM TVVDAIDQVL QHRCILPNRG FLKQLRELDI KLALERRDNM
210
NGTNSSEKTG TSTETEI
Length:217
Mass (Da):24,410
Last modified:July 24, 2007 - v1
Checksum:iF5A23775C2FDC3AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ01006385 Genomic DNA No translation available.
AAWZ01006387 Genomic DNA No translation available.
UniGeneiAcr.11361

Entry informationi

Entry nameiDUPD1_ANOCA
AccessioniPrimary (citable) accession number: P0C598
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health