P0C597 (DUPD1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase DUPD1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

DUPD1

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Dual specificity phosphatase DUPD1		PRO_0000295883
Regions
	Domain	46 – 193	148	Tyrosine-protein phosphatase
	Region	138 – 145	8	Substrate binding By similarity
Sites
	Active site	139	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C597 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 7ED254A3C511B503	FASTA	214	24,322
	10 20 30 40 50 60 MSSAGLNVGK KNAYTAVKVD PDGDYCTPGA FELERLFWKG CPKYTHVNEV WPNLYIGDEK 70 80 90 100 110 120 TALDRYSLEK AGFTHILNAA HGQRNVDTGP EYYQDMTVEY HGVEADDLPT FKLSQFFYSA 130 140 150 160 170 180 SEFIDNALQD ERNKVLVHCA MGRSRSATLV LAYLMIYKNM TVVDAIEQVS RHRCILPNRG 190 200 210 FLKQLRELDI ELALQRRNTK NSLPSNDDEN STTI

References

[1]

"ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels." Savolainen P., Fitzsimmons C., Arvestad L., Andersson L., Lundeberg J. Cytogenet. Genome Res. 111:79-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: White leghorn. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CN231188 mRNA. No translation available.
IPI	IPI00582699.
UniGene	Gga.11383.
3D structure databases
ProteinModelPortal	P0C597.
ModBase	Search...
Proteomic databases
PaxDb	P0C597.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000008036; ENSGALP00000008022; ENSGALG00000005019.
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00550000074474.
HOGENOM	HOG000233767.
HOVERGEN	HBG001524.
OMA	MTVVDAI.
OrthoDB	EOG4R23W1.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_CHICK

Accession

Primary (citable) accession number: P0C597

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program