Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity phosphatase DUPD1

Gene

Dupd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dupd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1310229 Dupd1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958811 – 215Dual specificity phosphatase DUPD1Add BLAST215

Proteomic databases

PaxDbiP0C595
PRIDEiP0C595

PTM databases

iPTMnetiP0C595
PhosphoSitePlusiP0C595

Expressioni

Gene expression databases

BgeeiENSRNOG00000013034

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017483

Structurei

3D structure databases

ProteinModelPortaliP0C595
SMRiP0C595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 200Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 152Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiP0C595
KOiK14165
OMAiHSKILVH
OrthoDBiEOG091G0249
PhylomeDBiP0C595
TreeFamiTF105128

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P0C595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGDTKTSV KHAHPCAERL SLQQEEGEAE DYCTPGAFEL ERLFWKGSPQ
60 70 80 90 100
YTHVNEVWPR LHVGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPDYY
110 120 130 140 150
RDMAIEYHGV EADDVPTFDL SIFFYSAAAF IDSALQDDHS KILVHCAMGR
160 170 180 190 200
SRSATLVLAY LMIHKNMTLV DAIQQVAKNR CVLPNRGFLK QLRELDKQLV
210
KQRRQAGPGA GELGL
Length:215
Mass (Da):24,073
Last modified:July 24, 2007 - v1
Checksum:i3B8406772551A6A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03097387 Genomic DNA No translation available.
AABR03097028 Genomic DNA No translation available.
AW918423 mRNA No translation available.
AW918455 mRNA No translation available.
RefSeqiNP_001101838.1, NM_001108368.1
XP_006251709.1, XM_006251647.3
XP_017455221.1, XM_017599732.1
UniGeneiRn.162035

Genome annotation databases

EnsembliENSRNOT00000017483; ENSRNOP00000017483; ENSRNOG00000013034
GeneIDi361003
KEGGirno:361003
UCSCiRGD:1310229 rat

Similar proteinsi

Entry informationi

Entry nameiDUPD1_RAT
AccessioniPrimary (citable) accession number: P0C595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health