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P0C594

- DUPD1_PANTR

UniProt

P0C594 - DUPD1_PANTR

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Protein
Dual specificity phosphatase DUPD1
Gene
DUPD1
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 10

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Dual specificity phosphatase DUPD1
PRO_0000295880Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000004609.

Structurei

3D structure databases

ProteinModelPortaliP0C594.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 201148Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1538Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00550000074474.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiP0C594.
KOiK14165.
OMAiYLMIHKD.
OrthoDBiEOG7CZK7N.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C594-1 [UniParc]FASTAAdd to Basket

« Hide

MTSGEVKTSL KNAYSSAKRL SLKMEEEGEE EDYCTPGAFE LERLFWKGSP    50
QYTHVNEVWP KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY 100
YRDMDIQYHG VEADDLPTFD LSVFFYPAAA FIDRALRDDH SKILVHCVMG 150
RSRSATLVLA YLMIHKDMTL VDAIQQVAKN RCVLPNRGFL KQLRELDKQL 200
VQQRRQAQRQ DGEEEDGREL 220
Length:220
Mass (Da):25,377
Last modified:July 24, 2007 - v1
Checksum:i26B250000B9F1A8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ02115231 Genomic DNA. No translation available.
AACZ02115232 Genomic DNA. No translation available.
RefSeqiXP_521513.2. XM_521513.3.

Genome annotation databases

EnsembliENSPTRT00000004993; ENSPTRP00000004609; ENSPTRG00000002653.
GeneIDi466111.
KEGGiptr:466111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ02115231 Genomic DNA. No translation available.
AACZ02115232 Genomic DNA. No translation available.
RefSeqi XP_521513.2. XM_521513.3.

3D structure databases

ProteinModelPortali P0C594.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000004609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000004993 ; ENSPTRP00000004609 ; ENSPTRG00000002653 .
GeneIDi 466111.
KEGGi ptr:466111.

Organism-specific databases

CTDi 338599.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00550000074474.
HOGENOMi HOG000233767.
HOVERGENi HBG001524.
InParanoidi P0C594.
KOi K14165.
OMAi YLMIHKD.
OrthoDBi EOG7CZK7N.
TreeFami TF105128.

Miscellaneous databases

NextBioi 20844295.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUPD1_PANTR
AccessioniPrimary (citable) accession number: P0C594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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