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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiMonodelphis domestica (Gray short-tailed opossum)
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958781 – 212Dual specificity phosphatase DUPD1Add BLAST212

Proteomic databases

PRIDEiP0C593.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi13616.ENSMODP00000000896.

Structurei

3D structure databases

ProteinModelPortaliP0C593.
SMRiP0C593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 193Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 145Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiP0C593.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRQSKTNL KNTYGSGKGE PEEDYITPGP FELERLFWKG SPQYTHVNEV
60 70 80 90 100
WPKLYIGDEA TALDRYSLEK SGFTHVLNAA HGRWNVNTGP EYYRDMAIEY
110 120 130 140 150
HGVEADDLPT FNLSEFFYSA AEFIESALQS DRSKILVHCA MGRSRSATLV
160 170 180 190 200
LAYLMIYRNM TVVDAIEQVA KNRCVLPNRG FLKQLRELDK QLLLQRRNAQ
210
SNEEENLEEK EI
Length:212
Mass (Da):24,422
Last modified:July 24, 2007 - v1
Checksum:i8090351C50EA121C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFR03024074 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiDUPD1_MONDO
AccessioniPrimary (citable) accession number: P0C593
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 25, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families