Reviewed, UniProtKB/Swiss-Prot P0C592 (DUPD1_HORSE)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

DUPD1

Organism

Equus caballus (Horse)

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Dual specificity phosphatase DUPD1		PRO_0000295876
Regions
	Domain	53 – 200	148	Tyrosine-protein phosphatase
Sites
	Active site	146	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C592-1 [UniParc]. Last modified December 15, 2009. Version 2. Checksum: 95723FC02D7A4B57	FASTA	220	24,885
	10 20 30 40 50 60 MTSGEPKTSL KNACPSARRL LPKAEEEEEA DYCAPGAFEL ERLFWKGSPQ YTHVNEVWPK 70 80 90 100 110 120 LYIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPEYY RDMAIEYHGV EADDLPTFDL 130 140 150 160 170 180 SVFFYPAAAF IHAALGSDHN KILVHCVMGR SRSATLVLAY LMIHRNMTLV DAIQQVAKNR 190 200 210 220 CVLPNRGFLK QLRELDKQLV QQRRQAQSSD DSEKASEKEL

References

[1]

"Genome sequence, comparative analysis, and population genetics of the domestic horse." Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T. , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K. Science 326:865-867(2009) [PubMed: 19892987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Thoroughbred.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAWR02008201 Genomic DNA. No translation available.
RefSeq	XP_001917767.1.
3D structure databases
SMR	P0C592. Positions 39-206.
ModBase	Search...
Genome annotation databases
Ensembl	ENSECAT00000022108; ENSECAP00000018251; ENSECAG00000020752; Equus caballus. [Genome view]
GeneID	100072928.
Phylogenomic databases
InParanoid	P0C592.
Enzyme and pathway databases
BRENDA	3.1.3.16. 1464. 3.1.3.48. 1464.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_HORSE

Accession

Primary (citable) accession number: P0C592

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	December 15, 2009
Last modified:	January 19, 2010
This is version 16 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)