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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958761 – 220Dual specificity phosphatase DUPD1Add BLAST220

Proteomic databases

PaxDbiP0C592.
PeptideAtlasiP0C592.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000018251.

Structurei

3D structure databases

ProteinModelPortaliP0C592.
SMRiP0C592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 200Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 152Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiP0C592.
KOiK14165.
OMAiAKFIDSA.
OrthoDBiEOG091G0249.
TreeFamiTF105128.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGEPKTSL KNACPSARRL LPKAEEEEEA DYCAPGAFEL ERLFWKGSPQ
60 70 80 90 100
YTHVNEVWPK LYIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPEYY
110 120 130 140 150
RDMAIEYHGV EADDLPTFDL SVFFYPAAAF IHAALGSDHN KILVHCVMGR
160 170 180 190 200
SRSATLVLAY LMIHRNMTLV DAIQQVAKNR CVLPNRGFLK QLRELDKQLV
210 220
QQRRQAQSSD DSEKASEKEL
Length:220
Mass (Da):24,885
Last modified:December 15, 2009 - v2
Checksum:i95723FC02D7A4B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWR02008201 Genomic DNA. No translation available.
RefSeqiNP_001184023.1. NM_001197094.1.
UniGeneiEca.17245.

Genome annotation databases

EnsembliENSECAT00000022108; ENSECAP00000018251; ENSECAG00000020752.
GeneIDi100072928.
KEGGiecb:100072928.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDUPD1_HORSE
AccessioniPrimary (citable) accession number: P0C592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 15, 2009
Last modified: July 5, 2017
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families