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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:17343 DUPD1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958761 – 220Dual specificity phosphatase DUPD1Add BLAST220

Proteomic databases

PaxDbiP0C592
PeptideAtlasiP0C592

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000018251

Structurei

3D structure databases

ProteinModelPortaliP0C592
SMRiP0C592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 200Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 152Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiP0C592
KOiK14165
OMAiHSKILVH
OrthoDBiEOG091G0249
TreeFamiTF105128

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P0C592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGEPKTSL KNACPSARRL LPKAEEEEEA DYCAPGAFEL ERLFWKGSPQ
60 70 80 90 100
YTHVNEVWPK LYIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPEYY
110 120 130 140 150
RDMAIEYHGV EADDLPTFDL SVFFYPAAAF IHAALGSDHN KILVHCVMGR
160 170 180 190 200
SRSATLVLAY LMIHRNMTLV DAIQQVAKNR CVLPNRGFLK QLRELDKQLV
210 220
QQRRQAQSSD DSEKASEKEL
Length:220
Mass (Da):24,885
Last modified:December 15, 2009 - v2
Checksum:i95723FC02D7A4B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWR02008201 Genomic DNA No translation available.
RefSeqiNP_001184023.1, NM_001197094.1
UniGeneiEca.17245

Genome annotation databases

EnsembliENSECAT00000022108; ENSECAP00000018251; ENSECAG00000020752
GeneIDi100072928
KEGGiecb:100072928

Similar proteinsi

Entry informationi

Entry nameiDUPD1_HORSE
AccessioniPrimary (citable) accession number: P0C592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 15, 2009
Last modified: April 25, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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