Reviewed, UniProtKB/Swiss-Prot P0C592 (DUPD1_HORSE)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

DUPD1

Organism

Equus caballus (Horse)

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Dual specificity phosphatase DUPD1		PRO_0000295876
Regions
	Domain	53 – 200	148	Tyrosine-protein phosphatase
Sites
	Active site	146	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C592-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 2006BB57AF040416	FASTA	216	24,443
	10 20 30 40 50 60 MTSGEPKTSL KNACPSARRL LPKAEEEEEA DYCAPGAFEL ERLFWKGSPQ YTHVNEVWPK 70 80 90 100 110 120 LYIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPEYY RDMAIEYHGV EADDLPTFDL 130 140 150 160 170 180 SVFFYPAAAF IHAALGSDHS KILVHCVMGR SRSATLVLAY LMIHRNMTLV DAIQQVAKNR 190 200 210 CVLPNRGFLK QLRELDKQLV QQRRQAQSSD DSEKEL

References

[1]	"The genome sequence of Equus caballus (horse)." Lindblad-Toh K., Gnerre S., Wade C.M., Bloecker H., Leeb T., Distl O., Lander E.S. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Thoroughbred.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ModBase	Search...
Genome annotation databases
Ensembl	ENSECAG00000020752. Equus caballus. [Contig view]
Enzyme and pathway databases
BRENDA	3.1.3.16. 1464. 3.1.3.48. 1464.
Family and domain databases
InterPro	IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_HORSE

Accession

Primary (citable) accession number: P0C592

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)