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P0C592 (DUPD1_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity phosphatase DUPD1

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:DUPD1
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Dual specificity phosphatase DUPD1
PRO_0000295876

Regions

Domain53 – 200148Tyrosine-protein phosphatase
Region145 – 1528Substrate binding By similarity

Sites

Active site1461Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C592 [UniParc].

Last modified December 15, 2009. Version 2.
Checksum: 95723FC02D7A4B57

FASTA22024,885
        10         20         30         40         50         60 
MTSGEPKTSL KNACPSARRL LPKAEEEEEA DYCAPGAFEL ERLFWKGSPQ YTHVNEVWPK 

        70         80         90        100        110        120 
LYIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPEYY RDMAIEYHGV EADDLPTFDL 

       130        140        150        160        170        180 
SVFFYPAAAF IHAALGSDHN KILVHCVMGR SRSATLVLAY LMIHRNMTLV DAIQQVAKNR 

       190        200        210        220 
CVLPNRGFLK QLRELDKQLV QQRRQAQSSD DSEKASEKEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAWR02008201 Genomic DNA. No translation available.
RefSeqNP_001184023.1. NM_001197094.1.
UniGeneEca.17245.

3D structure databases

ProteinModelPortalP0C592.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000018251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000022108; ENSECAP00000018251; ENSECAG00000020752.
GeneID100072928.
KEGGecb:100072928.

Organism-specific databases

CTD338599.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00550000074474.
HOGENOMHOG000233767.
HOVERGENHBG001524.
InParanoidP0C592.
KOK14165.
OMAYLMIHKD.
OrthoDBEOG7CZK7N.
TreeFamTF105128.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUPD1_HORSE
AccessionPrimary (citable) accession number: P0C592
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families