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P0C591 (DUPD1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity phosphatase DUPD1

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:DUPD1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Dual specificity phosphatase DUPD1
PRO_0000295875

Regions

Domain53 – 200148Tyrosine-protein phosphatase
Region145 – 1528Substrate binding By similarity

Sites

Active site1461Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C591 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: F5ED15F29BD7E36A

FASTA21924,984
        10         20         30         40         50         60 
MTSGESKTGL KNVYPSAKKL LPKVEEGEAE DYCTPGAFEL ERLFWKGSPQ YTHVNEVWPK 

        70         80         90        100        110        120 
LYIGDETTAL DRYGLQKAGF THVLNAAHGR WNVDTGPDYY RDMAIEYHGV EADDLPSFDL 

       130        140        150        160        170        180 
SVFFYPAAAF IDAALRYDHN KILVHCVMGR SRSATLVLAY LMIHRNMTLV DAIQQVAKNR 

       190        200        210 
CVLPNRGFLK QLRELDRQLV QQRRQAQQGE DAEKCEQEP 

« Hide

References

[1]"Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle."
Smith T.P.L., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E., Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P., Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I., Karamycheva S. expand/collapse author list , Liang F., Quackenbush J., Keele J.W.
Genome Res. 11:626-630(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BF074326 mRNA. No translation available.
CK773828 mRNA. No translation available.
RefSeqXP_005226533.1. XM_005226476.1.
UniGeneBt.31893.

3D structure databases

ProteinModelPortalP0C591.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP0C591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000003800; ENSBTAP00000003800; ENSBTAG00000002924.
GeneID616082.
KEGGbta:616082.

Organism-specific databases

CTD338599.

Phylogenomic databases

eggNOGNOG270281.
GeneTreeENSGT00550000074474.
HOGENOMHOG000233767.
HOVERGENHBG001524.
InParanoidP0C591.
KOK14165.
OMAYLMIHKD.
OrthoDBEOG7CZK7N.
TreeFamTF105128.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUPD1_BOVIN
AccessionPrimary (citable) accession number: P0C591
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families