P0C591 (DUPD1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase DUPD1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

DUPD1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Dual specificity phosphatase DUPD1		PRO_0000295875
Regions
	Domain	53 – 200	148	Tyrosine-protein phosphatase
	Region	145 – 152	8	Substrate binding By similarity
Sites
	Active site	146	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C591 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: F5ED15F29BD7E36A	FASTA	219	24,984
	10 20 30 40 50 60 MTSGESKTGL KNVYPSAKKL LPKVEEGEAE DYCTPGAFEL ERLFWKGSPQ YTHVNEVWPK 70 80 90 100 110 120 LYIGDETTAL DRYGLQKAGF THVLNAAHGR WNVDTGPDYY RDMAIEYHGV EADDLPSFDL 130 140 150 160 170 180 SVFFYPAAAF IDAALRYDHN KILVHCVMGR SRSATLVLAY LMIHRNMTLV DAIQQVAKNR 190 200 210 CVLPNRGFLK QLRELDRQLV QQRRQAQQGE DAEKCEQEP

References

[1]

"Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle." Smith T.P.L., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E., Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P., Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I., Karamycheva S. , Liang F., Quackenbush J., Keele J.W. Genome Res. 11:626-630(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BF074326 mRNA. No translation available. CK773828 mRNA. No translation available.
IPI	IPI00704172.
UniGene	Bt.31893.
3D structure databases
ProteinModelPortal	P0C591.
ModBase	Search...
Proteomic databases
PRIDE	P0C591.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003800; ENSBTAP00000003800; ENSBTAG00000002924.
Phylogenomic databases
eggNOG	NOG270281.
GeneTree	ENSGT00550000074474.
HOGENOM	HOG000233767.
HOVERGEN	HBG001524.
InParanoid	P0C591.
OMA	MTVVDAI.
OrthoDB	EOG4R23W1.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_BOVIN

Accession

Primary (citable) accession number: P0C591

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program