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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUPD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Organism-specific databases

VGNCiVGNC:28245 DUPD1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958751 – 219Dual specificity phosphatase DUPD1Add BLAST219

Proteomic databases

PaxDbiP0C591
PRIDEiP0C591

Expressioni

Gene expression databases

BgeeiENSBTAG00000002924

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003800

Structurei

3D structure databases

ProteinModelPortaliP0C591
SMRiP0C591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 200Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 152Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiP0C591
OMAiHSKILVH
OrthoDBiEOG091G0249
TreeFamiTF105128

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P0C591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGESKTGL KNVYPSAKKL LPKVEEGEAE DYCTPGAFEL ERLFWKGSPQ
60 70 80 90 100
YTHVNEVWPK LYIGDETTAL DRYGLQKAGF THVLNAAHGR WNVDTGPDYY
110 120 130 140 150
RDMAIEYHGV EADDLPSFDL SVFFYPAAAF IDAALRYDHN KILVHCVMGR
160 170 180 190 200
SRSATLVLAY LMIHRNMTLV DAIQQVAKNR CVLPNRGFLK QLRELDRQLV
210
QQRRQAQQGE DAEKCEQEP
Length:219
Mass (Da):24,984
Last modified:July 24, 2007 - v1
Checksum:iF5ED15F29BD7E36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BF074326 mRNA No translation available.
CK773828 mRNA No translation available.
RefSeqiXP_005226533.1, XM_005226476.3
UniGeneiBt.31893

Genome annotation databases

EnsembliENSBTAT00000003800; ENSBTAP00000003800; ENSBTAG00000002924
GeneIDi616082

Similar proteinsi

Entry informationi

Entry nameiDUPD1_BOVIN
AccessioniPrimary (citable) accession number: P0C591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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