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Protein

Pro-tricyclons

Gene
N/A
Organism
Viola arvensis (European field pansy) (Field violet)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Has a weak hemolytic activity.1 Publication

Miscellaneous

Tricyclon-A and tricyclon-B are hybrids of the Bracelet and Moebius subfamilies.

GO - Biological processi

Keywordsi

Biological processCytolysis, Hemolysis, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-tricyclons
Cleaved into the following 2 chains:
OrganismiViola arvensis (European field pansy) (Field violet)
Taxonomic identifieri97415 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesViolaceaeViola

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029577023 – 204Pro-tricyclonsAdd BLAST182
PropeptideiPRO_000029577123 – 72NTRAdd BLAST50
PeptideiPRO_000029577273 – 105Tricyclon-AAdd BLAST33
PropeptideiPRO_0000295773106 – 118Add BLAST13
PropeptideiPRO_0000295774119 – 167NTRAdd BLAST49
PeptideiPRO_0000295775168 – 200Tricyclon-BAdd BLAST33
PropeptideiPRO_0000295776201 – 2044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki73 ↔ 105Cyclopeptide (Gly-Asn)
Disulfide bondi79 ↔ 931 Publication
Disulfide bondi83 ↔ 951 Publication
Disulfide bondi88 ↔ 1011 Publication
Cross-linki168 ↔ 200Cyclopeptide (Gly-Asn)
Disulfide bondi174 ↔ 188By similarity
Disulfide bondi178 ↔ 190By similarity
Disulfide bondi183 ↔ 196By similarity

Post-translational modificationi

Proteolytically processed in two steps to yield first two linear precursors, and then two cyclic peptides after removal of the N-terminal repeats (NTR) and short tails.

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi84 – 86Combined sources3
Beta strandi93 – 96Combined sources4
Turni97 – 99Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YP8NMR-A79-173[»]
ProteinModelPortaliP0C589.
SMRiP0C589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C589.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines those proteins as knottins.

Sequence similaritiesi

Belongs to the cyclotide family.Curated

Keywords - Domaini

Knottin, Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR005535. Cyclotide.
IPR012324. Cyclotide_moebius_CS.
PfamiView protein in Pfam
PF03784. Cyclotide. 2 hits.
SUPFAMiSSF57038. SSF57038. 2 hits.
PROSITEiView protein in PROSITE
PS60009. CYCLOTIDE_MOEBIUS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTMASFVLV LVAAFALPAA FASLETKDVI TRAAYEKLVE SGAIQGITMT
60 70 80 90 100
KTIISNPILE EALVAHFNRK LGGGTIFDCG ESCFLGTCYT KGCSCGEWKL
110 120 130 140 150
CYGTNSLPES NNEKAMVASL EKDVITRAAY ENLVNSGAIQ GITMTKTIIS
160 170 180 190 200
NPILEEALVS HFNRKLGGGT IFDCGESCFL GTCYTKGCSC GEWKLCYGEN

SLAI
Length:204
Mass (Da):21,820
Last modified:July 24, 2007 - v1
Checksum:i76EAFD7DB07329C4
GO

Entry informationi

Entry nameiTRIC_VIOAR
AccessioniPrimary (citable) accession number: P0C589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families