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Protein

Metal transporter CNNM4

Gene

Cnnm4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function.2 Publications

Miscellaneous

Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiomineralization, Ion transport, Sensory transduction, Transport, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Metal transporter CNNM4
Alternative name(s):
Ancient conserved domain-containing protein 4
Cyclin-M4
Gene namesi
Name:Cnnm4
Synonyms:Acdp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1305571 Cnnm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 175ExtracellularSequence analysisAdd BLAST175
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 237CytoplasmicSequence analysisAdd BLAST41
Intramembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 261CytoplasmicSequence analysis3
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 290ExtracellularSequence analysis8
Transmembranei291 – 313HelicalSequence analysisAdd BLAST23
Topological domaini314 – 772CytoplasmicSequence analysisAdd BLAST459

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957671 – 772Metal transporter CNNM4Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei658PhosphoserineBy similarity1
Modified residuei662PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP0C588
PRIDEiP0C588

PTM databases

iPTMnetiP0C588
PhosphoSitePlusiP0C588

Expressioni

Tissue specificityi

Present in spinal cord dorsal horn neurons and in developing teeth (at protein level). In the tooth, higher expression is found in the ameloblasts during the transition and maturation phases of amelogenesis; reduced eypression in the odontoblasts.2 Publications

Gene expression databases

BgeeiENSRNOG00000015886
ExpressionAtlasiP0C588 baseline and differential
GenevisibleiP0C588 RN

Interactioni

Subunit structurei

Interacts with COX11.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021434

Structurei

3D structure databases

ProteinModelPortaliP0C588
SMRiP0C588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 356CNNM transmembranePROSITE-ProRule annotationAdd BLAST181
Domaini375 – 436CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini443 – 509CBS 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the ACDP family.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2118 Eukaryota
COG1253 LUCA
GeneTreeiENSGT00390000002383
HOGENOMiHOG000231947
HOVERGENiHBG074775
InParanoidiP0C588
KOiK16302
OMAiWLKWTDK
OrthoDBiEOG091G02YS
PhylomeDBiP0C588
TreeFamiTF101012

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR018490 cNMP-bd-like
IPR002550 DUF21
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF01595 DUF21, 1 hit
SUPFAMiSSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS51846 CNNM, 1 hit

Sequencei

Sequence statusi: Complete.

P0C588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGGGGGRR DGWPARGRLL LAALLLLLWT RAASGQSSPQ QSVILGMRLA
60 70 80 90 100
SCNKSCGMNP DGIIFVSEGS TVNLRLYGHR LGEISSNLIS FTEVDDAETV
110 120 130 140 150
HNSTNCLELT KDLVVQRLVN VSRGNTSGML VVITKFLRRS ENMKLYALCT
160 170 180 190 200
RTRADGPWLK WTDKDSLLFM VEEHGRFLPL WLHILLVLVL LVLSGIFSGL
210 220 230 240 250
NLGLMALDPM ELRIVQNCGT EKERRYARKI EPIRRKGNYL LCSLLLGNVL
260 270 280 290 300
VNTSLTILLD NLIGSGIMAV ASSTIGIVIF GEILPQALCS RHGLAVGANT
310 320 330 340 350
IVLTKIFMLL TFPLSFPISK LLDFVLGQEI RTVYNREKLM EMLKVTEPYN
360 370 380 390 400
DLVKEELNMI QGALELRTKT VEDIMTQLHD CFMIRSDAIL DFNTMSEIME
410 420 430 440 450
SGYTRIPVFE DEQSNIVDIL YVKDLAFVDP DDCTPLKTIT RFYNHPVHFV
460 470 480 490 500
FHDTKLDAML EEFKKGKSHL AIVQKVNNEG EGDPFYEVLG LVTLEDVIEE
510 520 530 540 550
IIKSEILDES DTYTDNRTRK RVSMKNKRDF SAFKDADNEL KVKISPQLLL
560 570 580 590 600
AAHRFLATEV PQFSPSLMSE KILLRLLKYP DVIQELRFDE HNKHCTRHYL
610 620 630 640 650
YTRNKPADCF ILILQGKVEV EAGKENMKFE TGAFSYYGTM ALSLAPPDRS
660 670 680 690 700
PAHPTPLSRS ASLSYPDRNT DMTPSSLAGS NQFGSCILGQ YVSDFSVRAL
710 720 730 740 750
TDLQYIKVTR QQYQNGLLAS RMDNSPQLTL DGCATCTENL SERPELPVVD
760 770
ETTTLLNERN LLLHRASQEG TI
Length:772
Mass (Da):86,692
Last modified:July 24, 2007 - v1
Checksum:i992604232F9F70C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03067911 Genomic DNA No translation available.
AABR03068531 Genomic DNA No translation available.
RefSeqiNP_001257979.1, NM_001271050.1
UniGeneiRn.857

Genome annotation databases

EnsembliENSRNOT00000021434; ENSRNOP00000021434; ENSRNOG00000015886
GeneIDi363216
KEGGirno:363216
UCSCiRGD:1305571 rat

Similar proteinsi

Entry informationi

Entry nameiCNNM4_RAT
AccessioniPrimary (citable) accession number: P0C588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health