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P0C569 (PHOSP_MOKV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoprotein
Short name=Protein P
Alternative name(s):
Protein M1
Gene names
Name:P
OrganismMokola virus (MOKV) [Reference proteome]
Taxonomic identifier12538 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Lyssavirus
Virus hostCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Chodsigoa caovansunga (Shrew) [TaxID: 269271]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Rodentia [TaxID: 9989]

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus By similarity.

Subunit structure

Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host STAT1, STAT2 and PML By similarity.

Subcellular location

Phosphoprotein: Virion. Host cytoplasm By similarity.

Isoform P2: Host cytoplasm By similarity.

Isoform P3: Host nucleus By similarity.

Post-translational modification

Phosphorylated by host PKC and by an unknown kinase By similarity.

Sequence similarities

Belongs to the lyssavirus protein P family.

Alternative products

This entry describes 3 isoforms produced by alternative initiation. [Align] [Select]
Isoform P (identifier: P0C569-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform P2 (identifier: P0C569-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.
Isoform P3 (identifier: P0C569-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Phosphoprotein
PRO_0000295249

Regions

Motif49 – 5810Nuclear export signal By similarity
Motif212 – 2154Nuclear localization signal By similarity

Amino acid modifications

Modified residue2111Phosphoserine; by host PKC By similarity
Modified residue2721Phosphoserine; by host PKC By similarity

Natural variations

Alternative sequence1 – 5252Missing in isoform P3.
VSP_026896
Alternative sequence1 – 1919Missing in isoform P2.
VSP_026897

Secondary structure

1 .................. 303
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform P [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1B6EAEB985871A29

FASTA30334,205
        10         20         30         40         50         60 
MSKDLVHPSL IRAGIVELEM AEETTDLINR TIESNQAHLQ GEPLYVDSLP EDMSRLRIED 

        70         80         90        100        110        120 
KSRRTKTEEE ERDEGSSEED NYLSEGQDPL IPFQNFLDEI GARAVKRLKT GEGFFRVWSA 

       130        140        150        160        170        180 
LSDDIKGYVS TNIMTSGERD TKSIQIQTEP TASVSSGNES RHDSESMHDP NDKKDHTPDH 

       190        200        210        220        230        240 
DVVPDIESST DKGEIRDIEG EVAHQVAESF SKKYKFPSRS SGIFLWNFEQ LKMNLDDIVK 

       250        260        270        280        290        300 
AAMNVPGVER IAEKGGKLPL RCILGFVALD SSKRFRLLAD NDKVARLIQE DINSYMARLE 


EAE

« Hide

Isoform P2 [UniParc].

Checksum: 1381816DEE124F8C
Show »

FASTA28432,116
Isoform P3 [UniParc].

Checksum: 450D85714FD3ACB4
Show »

FASTA25128,404

References

[1]"The complete Mokola virus genome sequence: structure of the RNA-dependent RNA polymerase."
Le Mercier P., Jacob Y., Tordo N.
J. Gen. Virol. 78:1571-1576(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y09762 Genomic RNA. No translation available.
RefSeqYP_142351.1. NC_006429.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WZLX-ray2.10A1-303[»]
ProteinModelPortalP0C569.
SMRP0C569. Positions 188-297.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3159477.

Family and domain databases

InterProIPR004259. PP_M1.
[Graphical view]
PfamPF03012. PP_M1. 1 hit.
[Graphical view]
ProDomPD004155. PP_M1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceP0C569.

Entry information

Entry namePHOSP_MOKV
AccessionPrimary (citable) accession number: P0C569
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 3, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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