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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

Slc25a42

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1592346 Slc25a42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918191 – 318Mitochondrial coenzyme A transporter SLC25A42Add BLAST318

Proteomic databases

PaxDbiP0C546
PRIDEiP0C546

PTM databases

iPTMnetiP0C546
PhosphoSitePlusiP0C546

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in adipose, followed by hypothalamus and brain coronal sections containing corpus callosum, fornix, thalamus, hypothalamus, optic chiasm, pons, midbrain, and cerebellum.1 Publication

Gene expression databases

GenevisibleiP0C546 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027615

Structurei

3D structure databases

ProteinModelPortaliP0C546
SMRiP0C546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 117Solcar 1Add BLAST87
Repeati129 – 214Solcar 2Add BLAST86
Repeati224 – 312Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
HOGENOMiHOG000165726
HOVERGENiHBG104402
InParanoidiP0C546
OrthoDBiEOG091G0C8S
PhylomeDBiP0C546

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P0C546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGVQEGSV RLGEDAEAVL AGAVSTKANH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRLLYFT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
IPYAAIQFSA HEEYKRILGH YYGFRGEALP PWPRLLAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYFGF TPTVLGVIPY
210 220 230 240 250
AGLSFFTYES LKSLHREYSG RPQPYPFERM VFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GHQHGSILST LRSIVREEGA VRGLYKGLSM NWLKGPIAVG
310
ISFTTFDLMQ ILLRQLQS
Length:318
Mass (Da):35,100
Last modified:June 26, 2007 - v1
Checksum:iA5E0DB2B59D67E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100959 Genomic DNA No translation available.
AABR03100708 Genomic DNA No translation available.
UniGeneiRn.17455

Genome annotation databases

UCSCiRGD:1592346 rat

Similar proteinsi

Entry informationi

Entry nameiS2542_RAT
AccessioniPrimary (citable) accession number: P0C546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health