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P0C529 (NDVA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-(1-->2)glucan export ATP-binding/permease protein NdvA

EC=3.6.3.42
Gene names
Name:ndvA
Ordered Locus Names:BruAb1_1004
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity.

Catalytic activity

ATP + H2O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).

Subunit structure

Homodimer By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Domain

In NdvA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similarities

Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentATP-binding cassette (ABC) transporter complex

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

beta-glucan-transporting ATPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Beta-(1-->2)glucan export ATP-binding/permease protein NdvA
PRO_0000290244

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane276 – 29621Helical; Potential
Domain21 – 301281ABC transmembrane type-1
Domain335 – 569235ABC transporter
Nucleotide binding368 – 3758ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P0C529 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2626C3220E57341C

FASTA59965,951
        10         20         30         40         50         60 
MSLLKIYWRA MQYLAVERTA TITMCVASVL VALVTLAEPV LFGRVIQSIS DKGDIFSPLL 

        70         80         90        100        110        120 
MWAALGGFNI MAAVFVARGA DRLAHRRRLG VMIDSYERLI TMPLAWHQKR GTSNALHTLI 

       130        140        150        160        170        180 
RATDSLFTLW LEFMRQHLTT VVALATLIPV AMTMDMRMSL VLIVLGVIYV MIGQLVMRKT 

       190        200        210        220        230        240 
KDGQAAVEKH HHKLFEHVSD TISNVSVVQS YNRIASETQA LRDYAKNLEN AQFPVLNWWA 

       250        260        270        280        290        300 
LASGLNRMAS TFSMVVVLVL GAYFVTKGQM RVGDVIAFIG FAQLMIGRLD QISAFINQTV 

       310        320        330        340        350        360 
TARAKLEEFF QMEDATADRQ EPENVADLND VKGDIVFDNV TYEFPNSGQG VYDVSFEVKP 

       370        380        390        400        410        420 
GQTVAIVGPT GAGKTTLINL LQRVFDPAAG RIMIDGTDTR TVSRRSLRHA IATVFQDAGL 

       430        440        450        460        470        480 
FNRSVEDNIR VGRANATHEE VHAAAKAAAA HDFILAKSEG YDTFVGERGS QLSGGERQRL 

       490        500        510        520        530        540 
AIARAILKDS PILVLDEATS ALDVETEEKV TQAVDELSHN RTTFIIAHRL STVRSADLVL 

       550        560        570        580        590 
FMDKGHLVES GSFNELAERG GRFSDLLRAG GLKLEDKQPK QPVVEGSNVM PFPVKGAVA 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX74354.1.
RefSeqYP_221715.1. NC_006932.1.

3D structure databases

ProteinModelPortalP0C529.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX74354; AAX74354; BruAb1_1004.
GeneID3340573.
KEGGbmb:BruAb1_1004.
PATRIC17823675. VBIBruAbo15061_1062.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1132.
KOK06147.
OMASMPLSWH.
OrthoDBEOG6T7N3V.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1023-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR017902. ABC_bGlucan_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005896. NdvA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsTIGR01192. chvA. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51317. NDVA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDVA_BRUAB
AccessionPrimary (citable) accession number: P0C529
Secondary accession number(s): Q57DD0, Q844Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names