P0C529 (NDVA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-(1-->2)glucan export ATP-binding/permease protein NdvA
EC=3.6.3.42

Gene names

Name:	ndvA
Ordered Locus Names:	BruAb1_1004

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity.
Catalytic activity	ATP + H2O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).
Subunit structure	Homodimer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Domain	In NdvA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence similarities	Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW beta-glucan-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Beta-(1-->2)glucan export ATP-binding/permease protein NdvA		PRO_0000290244
Regions
	Transmembrane	22 – 42	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	276 – 296	21	Helical; Potential
	Domain	21 – 301	281	ABC transmembrane type-1
	Domain	335 – 569	235	ABC transporter
	Nucleotide binding	368 – 375	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C529 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 2626C3220E57341C	FASTA	599	65,951
	10 20 30 40 50 60 MSLLKIYWRA MQYLAVERTA TITMCVASVL VALVTLAEPV LFGRVIQSIS DKGDIFSPLL 70 80 90 100 110 120 MWAALGGFNI MAAVFVARGA DRLAHRRRLG VMIDSYERLI TMPLAWHQKR GTSNALHTLI 130 140 150 160 170 180 RATDSLFTLW LEFMRQHLTT VVALATLIPV AMTMDMRMSL VLIVLGVIYV MIGQLVMRKT 190 200 210 220 230 240 KDGQAAVEKH HHKLFEHVSD TISNVSVVQS YNRIASETQA LRDYAKNLEN AQFPVLNWWA 250 260 270 280 290 300 LASGLNRMAS TFSMVVVLVL GAYFVTKGQM RVGDVIAFIG FAQLMIGRLD QISAFINQTV 310 320 330 340 350 360 TARAKLEEFF QMEDATADRQ EPENVADLND VKGDIVFDNV TYEFPNSGQG VYDVSFEVKP 370 380 390 400 410 420 GQTVAIVGPT GAGKTTLINL LQRVFDPAAG RIMIDGTDTR TVSRRSLRHA IATVFQDAGL 430 440 450 460 470 480 FNRSVEDNIR VGRANATHEE VHAAAKAAAA HDFILAKSEG YDTFVGERGS QLSGGERQRL 490 500 510 520 530 540 AIARAILKDS PILVLDEATS ALDVETEEKV TQAVDELSHN RTTFIIAHRL STVRSADLVL 550 560 570 580 590 FMDKGHLVES GSFNELAERG GRFSDLLRAG GLKLEDKQPK QPVVEGSNVM PFPVKGAVA

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX74354.1.
RefSeq	YP_221715.1. NC_006932.1.
3D structure databases
ProteinModelPortal	P0C529.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX74354; AAX74354; BruAb1_1004.
GeneID	3340573.
KEGG	bmb:BruAb1_1004.
PATRIC	17823675. VBIBruAbo15061_1062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1132.
KO	K06147.
OMA	NQISEAR.
ProtClustDB	PRK13657.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1023-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR017902. ABC_bGlucan_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005896. NdvA. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
TIGRFAMs	TIGR01192. chvA. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51317. NDVA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDVA_BRUAB

Accession

Primary (citable) accession number: P0C529
Secondary accession number(s): Q57DD0, Q844Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program