Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Conotoxin sr7a

Gene
N/A
Organism
Conus spurius (Alphabet cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Elicits hyperactivity when injected intracranially into mice and produces paralysis when injected into the pedal muscle of freshwater snails, Pomacea paludosa, but it has no apparent effect after intramuscular injection into the limpet Patella opea or the freshwater fish Lebistes reticulatus.

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin sr7a
OrganismiConus spurius (Alphabet cone)
Taxonomic identifieri192919 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusLindaconus

Organism-specific databases

ConoServeri1450 SrVIIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002889471 – 32Conotoxin sr7aAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 17By similarity
Disulfide bondi8 ↔ 21By similarity
Disulfide bondi16 ↔ 31By similarity
Modified residuei32Serine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PRIDEiP0C352

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiP0C352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P0C352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
CLQFGSTCFL GDDDICCSGE CFYSGGTFGI CS
Length:32
Mass (Da):3,337
Last modified:May 29, 2007 - v1
Checksum:i5AF71686F6926D7F
GO

Mass spectrometryi

Molecular mass is 3329.74 Da from positions 1 - 32. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiC7A_CONSP
AccessioniPrimary (citable) accession number: P0C352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health