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Protein

Alpha-conotoxin PIB

Gene
N/A
Organism
Conus purpurascens (Purple cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin causes paralysis upon intramuscular injection into goldfish and blocks both fetal (alpha-1/beta-1/delta-gamma subunits) and adult (alpha-1/beta-1/delta-epsilon subunits) subtypes of vertebrate muscle nAChRs in a dose-dependent manner.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin PIB
OrganismiConus purpurascens (Purple cone)
Taxonomic identifieri41690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri38. PIB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002889461 – 16Alpha-conotoxin PIBAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Modified residuei34-hydroxyproline1 Publication1
Disulfide bondi5 ↔ 11By similarity
Disulfide bondi6 ↔ 16By similarity
Modified residuei16Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/4 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C351-1 [UniParc]FASTAAdd to basket

« Hide

        10 
QSPGCCWNPA CVKNRC
Length:16
Mass (Da):1,766
Last modified:May 29, 2007 - v1
Checksum:i42619D9EFA10EB5C
GO

Mass spectrometryi

Molecular mass is 1760.73 Da from positions 1 - 16. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCA1B_CONPU
AccessioniPrimary (citable) accession number: P0C351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families