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Protein

U1-theraphotoxin-Cg1a 1

Gene
N/A
Organism
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable ion channel inhibitor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
U1-theraphotoxin-Cg1a 1
Short name:
U1-TRTX-Cg1a
Alternative name(s):
Jingzhaotoxin-7
Short name:
JZTX-7
Jingzhaotoxin-VII
Short name:
JZTX-VII
Peptide F5-16.20
OrganismiChilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Taxonomic identifieri278060 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeChilobrachys

Organism-specific databases

ArachnoServeriAS000048. U1-theraphotoxin-Cg1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000039838422 – 292 Publications8
PeptideiPRO_000028758430 – 63U1-theraphotoxin-Cg1a 1Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 461 Publication
Disulfide bondi38 ↔ 511 Publication
Disulfide bondi45 ↔ 581 Publication
Modified residuei63Proline amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Beta strandi46 – 52Combined sources7
Turni53 – 56Combined sources4
Beta strandi57 – 60Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZJQNMR-A30-63[»]
2AAPNMR-A30-63[»]
ProteinModelPortaliP0C2X7.
SMRiP0C2X7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2X7.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR011696. Huwentoxin-1.
IPR013140. Huwentoxin_CS1.
PfamiView protein in Pfam
PF07740. Toxin_12. 1 hit.
PROSITEiView protein in PROSITE
PS60021. HWTX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSALFVIF GLVLLFCNSF AAELKTTGRG CGGLMAGCDG KSTFCCSGYN
60
CSPTWKWCVY ARPGRR
Length:66
Mass (Da):7,140
Last modified:October 5, 2010 - v2
Checksum:iC60530FC804EECE6
GO

Mass spectrometryi

Molecular mass is 3604.5 Da from positions 30 - 63. Determined by MALDI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU233834 mRNA. Translation: ABY71653.1.

Similar proteinsi

Entry informationi

Entry nameiJZT7A_CHIGU
AccessioniPrimary (citable) accession number: P0C2X7
Secondary accession number(s): B1P1A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families