Reviewed, UniProtKB/Swiss-Prot P0C2W4 (CO1A2_TYREX)

Names and origin

Protein names

Recommended name:
    Collagen alpha-2(I) chain
Alternative name(s):
    Alpha-2 type I collagen

Gene names

Name:

COL1A2

Organism

Tyrannosaurus rex (Tyrant lizard king)

Taxonomic identifier

436495 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Tyrannosauridae › Tyrannosaurus

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subunit structure	Trimers of one alpha 2(I) and two alpha 1(I) chains By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrixBy similarity.
Post-translational modification	Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.
Miscellaneous	These protein fragments where extracted from a 68 millions years old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.
Sequence similarities	Belongs to the fibrillar collagen family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat
Molecular function	Structural protein
Technical term	Direct protein sequencing Extinct organism protein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›18	›18	Collagen alpha-2(I) chain
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P0C2W4-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 47D5FA729AE23B19	FASTA	18	1,579
	10 GLPGESGAVG PAGPIGSR

References

[1]	"Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass spectrometry." Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 316:280-285(2007) [PubMed: 17431180] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Bone.
[2]	"Interpreting sequences from mastodon and T. rex." Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 317:1324-1325(2007) [PubMed: 17823333] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CO1A2_TYREX

Accession

Primary (citable) accession number: P0C2W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	July 22, 2008
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)