P0C2W4 (CO1A2_TYREX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-2(I) chain

Alternative name(s):
Alpha-2 type I collagen

Gene names

Name:

COL1A2

Organism

Tyrannosaurus rex (Tyrant lizard king)

Taxonomic identifier

436495 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Tyrannosauridae › Tyrannosaurus

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subunit structure	Trimers of one alpha 2(I) and two alpha 1(I) chains.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Post-translational modification	Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Miscellaneous	These protein fragments where extracted from a 68 million years old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.
Sequence similarities	Belongs to the fibrillar collagen family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat
Technical term	Direct protein sequencing Extinct organism protein
Gene Ontology (GO)
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›18	›18	Collagen alpha-2(I) chain		PRO_0000286185
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P0C2W4 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 47D5FA729AE23B19	FASTA	18	1,579
	10 GLPGESGAVG PAGPIGSR

References

[1]	"Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass spectrometry." Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 316:280-285(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Bone.
[2]	"Interpreting sequences from mastodon and T. rex." Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 317:1324-1325(2007) [PubMed] [Europe PMC] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES.
[3]	"Comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'." Buckley M., Walker A., Ho S.Y., Yang Y., Smith C., Ashton P., Oates J.T., Cappellini E., Koon H., Penkman K., Elsworth B., Ashford D., Solazzo C., Andrews P., Strahler J., Shapiro B., Ostrom P., Gandhi H. , Miller W., Raney B., Zylber M.I., Gilbert M.T., Prigodich R.V., Ryan M., Rijsdijk K.F., Janoo A., Collins M.J. Science 319:33-33(2008) [PubMed] [Europe PMC] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF MASS SPECTROMETRY.
[4]	"Response to comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'." Asara J.M., Schweitzer M.H., Cantley L.C., Cottrell J.S. Science 319:33-33(2008) Cited for: COMMENTS ON INTERPRETATION OF MASS SPECTROMETRY.
[5]	"Comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'." Pevzner P.A., Kim S., Ng J. Science 321:1040-1040(2008) [PubMed] [Europe PMC] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF MASS SPECTROMETRY.
[6]	"Response to comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'." Asara J.M., Schweitzer M.H., Cantley L.C., Cottrell J.S. Science 321:1040-1040(2008) Cited for: COMMENTS ON INTERPRETATION OF MASS SPECTROMETRY.
[7]	"Reanalysis of Tyrannosaurus rex mass spectra." Bern M., Phinney B.S., Goldberg D. J. Proteome Res. 8:4328-4332(2009) [PubMed] [Europe PMC] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF MASS SPECTROMETRY.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CO1A2_TYREX

Accession

Primary (citable) accession number: P0C2W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	May 31, 2011
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program