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Collagen alpha-2(I) chain



Tyrannosaurus rex (Tyrant lizard king)
Reviewed-Annotation score: -Experimental evidence at protein leveli


Type I collagen is a member of group I collagen (fibrillar forming collagen).


These protein fragments where extracted from a 68-million-year-old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-2(I) chain
Alternative name(s):
Alpha-2 type I collagen
Gene namesi
OrganismiTyrannosaurus rex (Tyrant lizard king)
Taxonomic identifieri436495 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaTyrannosauridaeTyrannosaurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000286185‹1 – ›18Collagen alpha-2(I) chainAdd BLAST›18

Post-translational modificationi

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.


Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains.

Family & Domainsi

Sequence similaritiesi

Belongs to the fibrillar collagen family.Curated

Keywords - Domaini

Collagen, Repeat


Sequence statusi: Fragment.

Mass (Da):1,579
Last modified:May 1, 2007 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei181

Similar proteinsi

Entry informationi

Entry nameiCO1A2_TYREX
AccessioniPrimary (citable) accession number: P0C2W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing, Extinct organism protein


  1. SIMILARITY comments
    Index of protein domains and families

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