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P0C2W4 (CO1A2_TYREX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-2(I) chain
Alternative name(s):
Alpha-2 type I collagen
Gene names
Name:COL1A2
OrganismTyrannosaurus rex (Tyrant lizard king)
Taxonomic identifier436495 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaTyrannosauridaeTyrannosaurus

Protein attributes

Sequence length18 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subunit structure

Trimers of one alpha 2(I) and two alpha 1(I) chains.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Post-translational modification

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Miscellaneous

These protein fragments where extracted from a 68-million-year-old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.

Sequence similarities

Belongs to the fibrillar collagen family.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainCollagen
Repeat
   Technical termDirect protein sequencing
Extinct organism protein
Gene Ontology (GO)
   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›18›18Collagen alpha-2(I) chain
PRO_0000286185

Experimental info

Non-terminal residue11
Non-terminal residue181

Sequences

Sequence LengthMass (Da)Tools
P0C2W4 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 47D5FA729AE23B19

FASTA181,579
        10 
GLPGESGAVG PAGPIGSR 

« Hide

References

[1]"Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass spectrometry."
Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C.
Science 316:280-285(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Bone.
[2]"Interpreting sequences from mastodon and T. rex."
Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C.
Science 317:1324-1325(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES.
[3]"Comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'."
Buckley M., Walker A., Ho S.Y., Yang Y., Smith C., Ashton P., Oates J.T., Cappellini E., Koon H., Penkman K., Elsworth B., Ashford D., Solazzo C., Andrews P., Strahler J., Shapiro B., Ostrom P., Gandhi H. expand/collapse author list , Miller W., Raney B., Zylber M.I., Gilbert M.T., Prigodich R.V., Ryan M., Rijsdijk K.F., Janoo A., Collins M.J.
Science 319:33-33(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: COMMENTS ON INTERPRETATION OF IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Response to comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'."
Asara J.M., Schweitzer M.H., Cantley L.C., Cottrell J.S.
Science 319:33-33(2008)
Cited for: COMMENTS ON INTERPRETATION OF IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'."
Pevzner P.A., Kim S., Ng J.
Science 321:1040-1040(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: COMMENTS ON INTERPRETATION OF IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Response to comment on 'Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry'."
Asara J.M., Schweitzer M.H., Cantley L.C., Cottrell J.S.
Science 321:1040-1040(2008)
Cited for: COMMENTS ON INTERPRETATION OF IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Reanalysis of Tyrannosaurus rex mass spectra."
Bern M., Phinney B.S., Goldberg D.
J. Proteome Res. 8:4328-4332(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: COMMENTS ON INTERPRETATION OF IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCO1A2_TYREX
AccessionPrimary (citable) accession number: P0C2W4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families