Reviewed, UniProtKB/Swiss-Prot P0C2W3 (CO2A1_TYREX)

Names and origin

Protein names

Recommended name:
    Collagen alpha-1(II) chain
Alternative name(s):
    Alpha-1 type II collagen

Gene names

Name:

COL2A1

Organism

Tyrannosaurus rex (Tyrant lizard king)

Taxonomic identifier

436495 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Tyrannosauridae › Tyrannosaurus

Protein attributes

Sequence length	14 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces By similarity.
Subunit structure	Homotrimers of alpha 1(II) chains By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrixBy similarity.
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.
Miscellaneous	These protein fragments where extracted from a 68 millions years old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat
Technical term	Direct protein sequencing Extinct organism protein
Gene Ontology (GO)
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›14	›14	Collagen alpha-1(II) chain		PRO_0000286184
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	14	1

Sequences

	Sequence		Length	Mass (Da)
	P0C2W3-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 3D7835BEF84F9C28	FASTA	14	1,292
	10 GLVGAPGLRG LPGK

References

[1]	"Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass spectrometry." Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 316:280-285(2007) [PubMed: 17431180] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Bone.
[2]	"Interpreting sequences from mastodon and T. rex." Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C. Science 317:1324-1325(2007) [PubMed: 17823333] [Abstract] Cited for: COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CO2A1_TYREX

Accession

Primary (citable) accession number: P0C2W3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	November 25, 2008
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)