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Reviewed, UniProtKB/Swiss-Prot P0C2U1 (OTCC_LACLC)

Last modified July 28, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3
Gene names
Name: arcB
Ordered Locus Names: LL2036
OrganismLactococcus lactis subsp. cremoris (Streptococcus cremoris)
Taxonomic identifier1359 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the ATCase/OTCase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000285242

Regions

Region67 – 715Carbamoyl phosphate binding By similarity
Region283 – 2864Ornithine binding By similarity

Sites

Binding site1181Carbamoyl phosphate By similarity
Binding site1451Carbamoyl phosphate By similarity
Site421Important for structural integrity By similarity
Site1581Important for structural integrity By similarity

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Sequences

Sequence LengthMass (Da)Tools
P0C2U1-1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 30A21C19171FCBEE

FASTA35439,410
        10         20         30         40         50         60 
MTSPLITKAE VNSVFQGRSL LAEKDFTPAE INYLVDFGLH LKALKQQNIP HHYLEGKNIA 

        70         80         90        100        110        120 
LLFAKTSTRT RAAFTTAAID LGAHPEYLGA NDIQLGIKES TEDTARVLGS MFDAIERRGF 

       130        140        150        160        170        180 
SQKEVEDLAK YSGVPVWNGL TDDWHPTQMI ADFMTVKENF GYLKGLTLVY VGDGRNNMAN 

       190        200        210        220        230        240 
SLIVTGSMLG VNVHIVAPDS LHPSKEVMDI ANKFAEKSGA KPLATSNIEE GVKGANIIYS 

       250        260        270        280        290        300 
DVWVSMGESN WEERVKLLTP YRITMDMLKM TGNADNGKLI FMHCLPAFHD TETEYGKEIK 

       310        320        330        340        350 
EKYGLTEMEV TDAVFRSKYA RQFEEAENRM HSIKAIMAAT LGNLFIPAVP EDFK

« Hide

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References

[1]"Arginine metabolism in Lactococcus lactis ssp. lactis ML3: analysis of gene structure and study of expression profiles using the small-scale DNA array."
Chou L., Weimer B., Xie Y.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NCDO 763 / ML3.

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Cross-references

Sequence databases

AF282249 Genomic DNA. Translation: AAF86986.1.

3D structure databases

HSSPHSSP built from PDB template 1AKM based on UniProtKB P04391.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.1.3.3. 289716.

Family and domain databases

HAMAPMF_01109.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002292. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameOTCC_LACLC
AccessionPrimary (citable) accession number: P0C2U1
Secondary accession number(s): Q9CE14, Q9KGV4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 28, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents