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Reviewed, UniProtKB/Swiss-Prot P0C2U0 (OTCC_LACLA)

Last modified February 9, 2010. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3
Gene names
Name: arcB
Ordered Locus Names: LL2036
ORF Names: L0109
OrganismLactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]
Taxonomic identifier1360 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000112935

Regions

Region67 – 715Carbamoyl phosphate binding By similarity
Region283 – 2864Ornithine binding By similarity

Sites

Binding site1181Carbamoyl phosphate By similarity
Binding site1451Carbamoyl phosphate By similarity
Site421Important for structural integrity By similarity
Site1581Important for structural integrity By similarity

Experimental info

Sequence conflict1621H → Y Ref.1
Sequence conflict2041T → S Ref.1
Sequence conflict2781Q → K Ref.1
Sequence conflict3131E → A Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P0C2U0-1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 75C2F1BD423EFC98

FASTA35439,456
        10         20         30         40         50         60 
MTSPLITKAE VNSVFQGRSL LAEKDFTPAE INYLVDFGLH LKALKQQNIP HHYLEGKNIA 

        70         80         90        100        110        120 
LLFAKTSTRT RAAFTTAAID LGAHPEYLGA NDIQLGIKES TEDTARVLGS MFDAIERRGF 

       130        140        150        160        170        180 
SQKEVEDLAK YSGVPVWNGL TDDWHPTQMI ADFMTVKENF GHLKGLTLVY VGDGRNNMAN 

       190        200        210        220        230        240 
SLIVTGSMLG VNVHIVAPDS LHPTKEVMDI ANKFAEKSGA KPLATSNIEE GVKGANIIYS 

       250        260        270        280        290        300 
DVWVSMGESN WEERVKLLTP YRITMDMLKM TGNADNGQLI FMHCLPAFHD TETEYGKEIK 

       310        320        330        340        350 
EKYGLTEMEV TDEVFRSKYA RQFEEAENRM HSIKAIMAAT LGNLFIPAVP EDFK

« Hide

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References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK06134.1.
PIRD86879.
RefSeqNP_268193.1.

3D structure databases

SMRP0C2U0. Positions 14-344.
ModBaseSearch...

Genome annotation databases

GeneID1115712.
GenomeReviewsGene locus LL2036 in contig AE005176_GR.
KEGGlla:L0109.
NMPDRfig|272623.1.peg.2090.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMANHETVES.

Enzyme and pathway databases

BRENDA2.1.3.3. 278870.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002292. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameOTCC_LACLA
AccessionPrimary (citable) accession number: P0C2U0
Secondary accession number(s): Q9CE14, Q9KGV4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents