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P0C2T5

- ACMA_LACLC

UniProt

P0C2T5 - ACMA_LACLC

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Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. cremoris (Streptococcus cremoris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes the cell wall of L.lactis and M.lysodeikticus. Required for cell separation during growth.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. amidase activity Source: InterPro
  2. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cell wall organization Source: UniProtKB-KW
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramidase (EC:3.2.1.17)
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene namesi
Name:acmA
OrganismiLactococcus lactis subsp. cremoris (Streptococcus cremoris)
Taxonomic identifieri1359 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5757Sequence AnalysisAdd
BLAST
Chaini58 – 437380Probable N-acetylmuramidasePRO_0000012113Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0C2T5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati245 – 28743LysM 1Add
BLAST
Repeati321 – 36343LysM 2Add
BLAST
Repeati395 – 43743LysM 3Add
BLAST

Domaini

The LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 3 LysM repeats.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR018392. LysM_dom.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view]
PfamiPF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2T5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSRVKVKN RHLKKKTKKP LAFYKPTTKF VGAVLIAGTL TTTHELLLQQ
60 70 80 90 100
TSPMVQAATN SSEAFIESIA ASAKPVADAN GLYPSVMIAQ AILESNWGSS
110 120 130 140 150
QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS
160 170 180 190 200
FQDNTYVLKT TNFGNGPYYA KAWRANAATY QDATAALTGK YATDPSYGAS
210 220 230 240 250
LNRIISQYNL TRFDGASSAG NTNSGGSTTT NTNNNSGTNS SSTTYTVKSG
260 270 280 290 300
DTLWGISQRY GISVAQIQSA NNLKSTIIYI GQKLLLTGSA SSTNSGGSNN
310 320 330 340 350
SASTTPTTSV TPAKPASQTS VKVKSGDTLW ALSVKYKTSI AQLKSWNHLS
360 370 380 390 400
SDTIYIGQNL IVSQSAATSN PSTGSGSTAT NNSNSTSSNS NASIHKVVKG
410 420 430
DTLWGLSQKS GSPIASIKAW NHLSSDTILI GQYLRIK
Length:437
Mass (Da):46,597
Last modified:May 1, 2007 - v1
Checksum:i169778AF09E13963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036720 Genomic DNA. Translation: AAB93629.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036720 Genomic DNA. Translation: AAB93629.1 .

3D structure databases

ProteinModelPortali P0C2T5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR018392. LysM_dom.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view ]
Pfami PF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Varying influence of the autolysin, N-acetyl muramidase, and the cell envelope proteinase on the rate of autolysis of six commercial Lactococcus lactis cheese starter bacteria grown in milk."
    Govindasamy-Lucey S., Gopal P.K., Sullivan P.A., Pillidge C.J.
    J. Dairy Res. 67:585-596(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2250.

Entry informationi

Entry nameiACMA_LACLC
AccessioniPrimary (citable) accession number: P0C2T5
Secondary accession number(s): O52362, Q48603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3