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Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. cremoris (Streptococcus cremoris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes the cell wall of L.lactis and M.lysodeikticus. Required for cell separation during growth.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramidase (EC:3.2.1.17)
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene namesi
Name:acmA
OrganismiLactococcus lactis subsp. cremoris (Streptococcus cremoris)
Taxonomic identifieri1359 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 57Sequence analysisAdd BLAST57
ChainiPRO_000001211358 – 437Probable N-acetylmuramidaseAdd BLAST380

Proteomic databases

PRIDEiP0C2T5

Structurei

3D structure databases

ProteinModelPortaliP0C2T5
SMRiP0C2T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 286LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini319 – 362LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini393 – 436LysM 3PROSITE-ProRule annotationAdd BLAST44

Domaini

The LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4107X35 Bacteria
COG1388 LUCA
COG1705 LUCA

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR002901 MGlyc_endo_b_GlcNAc-like_dom
PfamiView protein in Pfam
PF01832 Glucosaminidase, 1 hit
PF01476 LysM, 3 hits
SMARTiView protein in SMART
SM00257 LysM, 3 hits
SM00047 LYZ2, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSRVKVKN RHLKKKTKKP LAFYKPTTKF VGAVLIAGTL TTTHELLLQQ
60 70 80 90 100
TSPMVQAATN SSEAFIESIA ASAKPVADAN GLYPSVMIAQ AILESNWGSS
110 120 130 140 150
QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS
160 170 180 190 200
FQDNTYVLKT TNFGNGPYYA KAWRANAATY QDATAALTGK YATDPSYGAS
210 220 230 240 250
LNRIISQYNL TRFDGASSAG NTNSGGSTTT NTNNNSGTNS SSTTYTVKSG
260 270 280 290 300
DTLWGISQRY GISVAQIQSA NNLKSTIIYI GQKLLLTGSA SSTNSGGSNN
310 320 330 340 350
SASTTPTTSV TPAKPASQTS VKVKSGDTLW ALSVKYKTSI AQLKSWNHLS
360 370 380 390 400
SDTIYIGQNL IVSQSAATSN PSTGSGSTAT NNSNSTSSNS NASIHKVVKG
410 420 430
DTLWGLSQKS GSPIASIKAW NHLSSDTILI GQYLRIK
Length:437
Mass (Da):46,597
Last modified:May 1, 2007 - v1
Checksum:i169778AF09E13963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036720 Genomic DNA Translation: AAB93629.1

Similar proteinsi

Entry informationi

Entry nameiACMA_LACLC
AccessioniPrimary (citable) accession number: P0C2T5
Secondary accession number(s): O52362, Q48603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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