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Protein

Soricidin

Gene
N/A
Organism
Blarina brevicauda (Northern short-tailed shrew)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Paralytic toxin. This peptide immobilizes a mealworm for 7 days. Because the paralyzed prey is still alive, there is no worry about spoilage.1 Publication

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Soricidin
Alternative name(s):
Ps peptide
OrganismiBlarina brevicauda (Northern short-tailed shrew)
Taxonomic identifieri9387 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeSoricinaeBlarina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

May be used for treatment of migraine, myofacial and other types of pain, muscle tremors, neuromuscular diseases, excessive sweating and wrinkles.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5454SoricidinPRO_0000283772Add
BLAST

Post-translational modificationi

Contains three disulfide bonds.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Salivary gland.

Interactioni

Subunit structurei

Member of a multiprotein complex.

Family & Domainsi

Family and domain databases

InterProiIPR006024. Opioid_neupept.
[Graphical view]
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C2P6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV

DLPR
Length:54
Mass (Da):5,813
Last modified:April 3, 2007 - v1
Checksum:i1D7F7D00021CEBC5
GO

Mass spectrometryi

Molecular mass is 5805.8 Da from positions 1 - 54. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281E → A.

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006024. Opioid_neupept.
[Graphical view]
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Shrew paralytic peptide for use in neuromuscular therapy."
    Stewart J.M., Steeves B.J., Vernes K.
    Patent number WO2004046178, 03-JUN-2004
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
    Tissue: Saliva.

Entry informationi

Entry nameiSORI_BLABR
AccessioniPrimary (citable) accession number: P0C2P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Pharmaceutical

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.