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P0C2P6 (SORI_BLABR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soricidin
Alternative name(s):
Ps peptide
OrganismBlarina brevicauda (Northern short-tailed shrew)
Taxonomic identifier9387 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeSoricinaeBlarina

Protein attributes

Sequence length54 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Paralytic toxin. This peptide immobilizes a mealworm for 7 days. Because the paralyzed prey is still alive, there is no worry about spoilage. Ref.1

Subunit structure

Member of a multiprotein complex.

Subcellular location

Secreted.

Tissue specificity

Salivary gland.

Post-translational modification

Contains three disulfide bonds.

Pharmaceutical use

May be used for treatment of migraine, myofacial and other types of pain, muscle tremors, neuromuscular diseases, excessive sweating and wrinkles.

Mass spectrometry

Molecular mass is 5805.8 Da from positions 1 - 54. Determined by MALDI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionToxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Pharmaceutical
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5454Soricidin
PRO_0000283772

Natural variations

Natural variant281E → A.

Sequences

Sequence LengthMass (Da)Tools
P0C2P6 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 1D7F7D00021CEBC5

FASTA545,813
        10         20         30         40         50 
DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV DLPR 

« Hide

References

[1]"Shrew paralytic peptide for use in neuromuscular therapy."
Stewart J.M., Steeves B.J., Vernes K.
Patent number WO2004046178, 03-JUN-2004
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
Tissue: Saliva.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR006024. Opioid_neupept.
[Graphical view]
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSORI_BLABR
AccessionPrimary (citable) accession number: P0C2P6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 31, 2012
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program