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P0C2P6

- SORI_BLABR

UniProt

P0C2P6 - SORI_BLABR

Protein

Soricidin

Gene
N/A
Organism
Blarina brevicauda (Northern short-tailed shrew)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Paralytic toxin. This peptide immobilizes a mealworm for 7 days. Because the paralyzed prey is still alive, there is no worry about spoilage.1 Publication

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Soricidin
    Alternative name(s):
    Ps peptide
    OrganismiBlarina brevicauda (Northern short-tailed shrew)
    Taxonomic identifieri9387 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeSoricinaeBlarina

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    May be used for treatment of migraine, myofacial and other types of pain, muscle tremors, neuromuscular diseases, excessive sweating and wrinkles.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5454SoricidinPRO_0000283772Add
    BLAST

    Post-translational modificationi

    Contains three disulfide bonds.

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Salivary gland.

    Interactioni

    Subunit structurei

    Member of a multiprotein complex.

    Family & Domainsi

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    [Graphical view]
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C2P6-1 [UniParc]FASTAAdd to Basket

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    DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV   50
    DLPR 54
    Length:54
    Mass (Da):5,813
    Last modified:April 3, 2007 - v1
    Checksum:i1D7F7D00021CEBC5
    GO

    Mass spectrometryi

    Molecular mass is 5805.8 Da from positions 1 - 54. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281E → A.

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    [Graphical view ]
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Shrew paralytic peptide for use in neuromuscular therapy."
      Stewart J.M., Steeves B.J., Vernes K.
      Patent number WO2004046178, 03-JUN-2004
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
      Tissue: Saliva.

    Entry informationi

    Entry nameiSORI_BLABR
    AccessioniPrimary (citable) accession number: P0C2P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Pharmaceutical

    External Data

    Dasty 3