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Protein

Soricidin

Gene
N/A
Organism
Blarina brevicauda (Northern short-tailed shrew)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the transient receptor potential cation channel subfamily V member 6 (TRPV6) (Ref. 2). Paralytic toxin (Ref. 1). This peptide immobilizes a mealworm for 7 days (Ref. 1).2 Publications

Miscellaneous

Two synthetic peptides SOR-C13 (AA 42-54) and SOR-C27 (AA 28-54) inhibit calcium influx in TRPV6 over-expressing cells (IC50=14 and IC50=65 nM, respectively).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Soricidin1 Publication
Alternative name(s):
Ps peptide1 Publication
OrganismiBlarina brevicauda (Northern short-tailed shrew)
Taxonomic identifieri9387 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraSoricidaeSoricinaeBlarina

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Is under phase I clinical trial by Soricimed under the name SOR-C13. This shorter analog (AA 42-54) of soricidin is tested for the treatment of advanced solid tumors of epithelial origin which are refractory to all standard-of-care treatments.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837721 – 54Soricidin1 PublicationAdd BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 23By similarity
Disulfide bondi6 ↔ 27By similarity
Disulfide bondi9 ↔ 41By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Salivary gland.1 Publication

Interactioni

Subunit structurei

Member of a multiprotein complex.2 Publications

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR006024 Opioid_neupept
PfamiView protein in Pfam
PF01160 Opiods_neuropep, 1 hit

Sequencei

Sequence statusi: Complete.

P0C2P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV

DLPR
Length:54
Mass (Da):5,813
Last modified:April 3, 2007 - v1
Checksum:i1D7F7D00021CEBC5
GO

Mass spectrometryi

Molecular mass is 5805.8 Da from positions 1 - 54. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiSORI_BLABR
AccessioniPrimary (citable) accession number: P0C2P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Pharmaceutical

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