P0C2P6 (SORI_BLABR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Soricidin Alternative name(s): Ps peptide
Organism	Blarina brevicauda (Northern short-tailed shrew)
Taxonomic identifier	9387 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Insectivora › Soricidae › Soricinae › Blarina

Protein attributes

Sequence length	54 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Paralytic toxin. This peptide immobilizes a mealworm for 7 days. Because the paralyzed prey is still alive, there is no worry about spoilage. Ref.1
Subunit structure	Member of a multiprotein complex.
Subcellular location	Secreted.
Tissue specificity	Salivary gland.
Post-translational modification	Contains three disulfide bonds.
Pharmaceutical use	May be used for treatment of migraine, myofacial and other types of pain, muscle tremors, neuromuscular diseases, excessive sweating and wrinkles.
Mass spectrometry	Molecular mass is 5805.8 Da from positions 1 - 54. Determined by MALDI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing Pharmaceutical
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 54	54	Soricidin		PRO_0000283772
Natural variations
	Natural variant	28	1	E → A.

Sequences

	Sequence		Length	Mass (Da)
	P0C2P6 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 1D7F7D00021CEBC5	FASTA	54	5,813
	10 20 30 40 50 DCSQDCAACS ILARPAELNT ETCILECEGK LSSNDTEGGL CKEFLHPSKV DLPR

References

[1]	"Shrew paralytic peptide for use in neuromuscular therapy." Stewart J.M., Steeves B.J., Vernes K. Patent number WO2004046178, 03-JUN-2004 Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION. Tissue: Saliva.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006024. Opioid_neupept. [Graphical view]
Pfam	PF01160. Opiods_neuropep. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SORI_BLABR

Accession

Primary (citable) accession number: P0C2P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	October 31, 2012
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program

Annotation program

Chordata Protein Annotation Program