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Protein

Histone-lysine N-methyltransferase KMT5C

Gene

Kmt5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-RNO-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase KMT5CCurated (EC:2.1.1.43)
Alternative name(s):
Lysine-specific methyltransferase 5CImported
Suppressor of variegation 4-20 homolog 2
Short name:
Su(var)4-20 homolog 2
Short name:
Suv4-20h2
Gene namesi
Name:Kmt5cImported
Synonyms:Suv420h2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305226 Kmt5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817951 – 470Histone-lysine N-methyltransferase KMT5CAdd BLAST470

Proteomic databases

PaxDbiP0C2N6
PRIDEiP0C2N6

PTM databases

iPTMnetiP0C2N6
PhosphoSitePlusiP0C2N6

Expressioni

Inductioni

Strongly down-regulated in various cancers such as hepatocarcinomas.2 Publications

Gene expression databases

BgeeiENSRNOG00000017508
GenevisibleiP0C2N6 RN

Interactioni

Subunit structurei

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023744

Structurei

3D structure databases

ProteinModelPortaliP0C2N6
SMRiP0C2N6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 218SETPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni350 – 443Required for heterochromatin localizationBy similarityAdd BLAST94

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589 Eukaryota
ENOG410XPH8 LUCA
GeneTreeiENSGT00520000055640
HOVERGENiHBG095676
InParanoidiP0C2N6
KOiK11429
OMAiFCAACQP
OrthoDBiEOG091G0IUY
PhylomeDBiP0C2N6
TreeFamiTF106433

Family and domain databases

InterProiView protein in InterPro
IPR025790 Hist-Lys_N-MTase_Suvar4-20
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51570 SAM_MT43_SUVAR420_2, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

P0C2N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP TLRRQHHLRS
60 70 80 90 100
ALEAFLRQRD LEAAFRALTL GGWMAHYFQN RAPRQEAALK NHIFCYLRAF
110 120 130 140 150
LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREEDE
160 170 180 190 200
YLLRAGENDF SVMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPSDGNTAC
210 220 230 240 250
VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CYTCERKGEG AFRLQPREPE
260 270 280 290 300
LRPRPLDKYE LRETKRRLQQ CLDSSQQNLL SLRACSHLSP LRPDPFCAAC
310 320 330 340 350
QPSCLLPVSP HMDYLPLWLQ WVPQPQPRVR PRKRRRRRRR RPRIPQASLS
360 370 380 390 400
PDLHTACVSL HRWGGCGPHC QLRAEAMVTL HLLPQTRWTP KQDWYWARRY
410 420 430 440 450
GLPSVVRVEL SPLAPALPAA PAPAGNLGPT PTPDLIPKQA LAFAPFCPPK
460 470
RLRLVVSHGS IDLDINSGEP
Length:470
Mass (Da):53,607
Last modified:April 3, 2007 - v1
Checksum:i060148E2FFFB49AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724526 mRNA No translation available.
RefSeqiNP_001100945.1, NM_001107475.1
XP_006228321.1, XM_006228259.1
XP_006228322.1, XM_006228260.1
XP_006228323.1, XM_006228261.1
XP_006228325.1, XM_006228263.1
XP_006228326.1, XM_006228264.1
XP_006228327.1, XM_006228265.3
XP_006228328.1, XM_006228266.1
UniGeneiRn.105145

Genome annotation databases

EnsembliENSRNOT00000023744; ENSRNOP00000023744; ENSRNOG00000017508
GeneIDi308345
KEGGirno:308345
UCSCiRGD:1305226 rat

Similar proteinsi

Entry informationi

Entry nameiKMT5C_RAT
AccessioniPrimary (citable) accession number: P0C2N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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