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P0C2N5

- SV421_RAT

UniProt

P0C2N5 - SV421_RAT

Protein

Histone-lysine N-methyltransferase SUV420H1

Gene

Suv420h1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB
    2. histone methyltransferase activity (H4-K20 specific) Source: Ensembl

    GO - Biological processi

    1. histone H4-K20 trimethylation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SUV420H1 (EC:2.1.1.43)
    Alternative name(s):
    Suppressor of variegation 4-20 homolog 1
    Short name:
    Su(var)4-20 homolog 1
    Short name:
    Suv4-20h1
    Gene namesi
    Name:Suv420h1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1311637. Suv420h1.

    Subcellular locationi

    Nucleus. Chromosome By similarity
    Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin By similarity.By similarity

    GO - Cellular componenti

    1. condensed nuclear chromosome, centromeric region Source: Ensembl

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 883883Histone-lysine N-methyltransferase SUV420H1PRO_0000281789Add
    BLAST

    Proteomic databases

    PaxDbiP0C2N5.
    PRIDEiP0C2N5.

    PTM databases

    PhosphoSiteiP0C2N5.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C2N5.

    Interactioni

    Subunit structurei

    Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2. Interacts (via C-terminus) with FRG1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022486.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C2N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini193 – 308116SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG325204.
    GeneTreeiENSGT00520000055640.
    HOVERGENiHBG105761.
    InParanoidiP0C2N5.
    KOiK11429.
    OMAiKLEMGNL.
    OrthoDBiEOG7MKW6P.
    PhylomeDBiP0C2N5.
    TreeFamiTF106433.

    Family and domain databases

    InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C2N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWLGDSKNM VVNGRRNGSK LSNDHQQNQS KLQHAGKDAL KTGRNAVERR    50
    PNRCHGNSGF EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM 100
    NTSAFPSRSS RHISKADSFS HNNPMRFRPI KGRQEELKEV IERFKKDEHL 150
    EKAFKCLTSG EWARHYFLNK NKMQEKLFKE HVFIYLRMFA TDSGFEILPC 200
    NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN MLLRHGENDF 250
    SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 300
    EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG 350
    LRETDKRLNR LKKLGDSSKS SDSQSVSSNT DADTTQEKDN ATSNRKSSVG 400
    VKKNSKSRAL TRQSMPRVPA ASNSTSPKLV HMNNSRVPKK LRKPAKPLLS 450
    KIKLRNHCKR LDQKSTSRKL EMGNLVLKEP KVVLYKNLPI KKEREAEGPV 500
    HAAVGSGCLT RHAAREHRQN PGRGAHSQGD SLPCTYTTRR SLRTRTGLKE 550
    TTDIKLAPSP LDGYKNGILE PYPDSGQQPT PEVLEELAPE TALREEASQE 600
    CPKSDSCPSR KKFRQGKPVK HLAKTEDCSP EHSFPGKDGL PDLPGPHPDQ 650
    GEPSGTVRVP VSYTDSAPSP VGCSIVTPDS FTTKDSFRTA QSKKKRRVTR 700
    YDAQLILENS SGIPKLTLRR RHDSSSKTND HESDSVNSSK ISIKLSKDHE 750
    SDSNLYVAKL SNGVSSGPGS SSTKLKIQLK RDEESRGPCA EGLHENGVCC 800
    SDPLSLLESQ MEVDDYSQYE EDSTDDSSSS EGEEEEEDCE DDFDDDFIPL 850
    PPAKRLRLIV GKDSIDIDIS SRRREDQSLR LNA 883
    Length:883
    Mass (Da):98,668
    Last modified:April 3, 2007 - v1
    Checksum:i1C5EAE2B39D2542F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03001123 Genomic DNA. No translation available.
    RefSeqiNP_001101982.1. NM_001108512.1.
    XP_006230893.1. XM_006230831.1.
    XP_006230894.1. XM_006230832.1.
    UniGeneiRn.203473.

    Genome annotation databases

    EnsembliENSRNOT00000022486; ENSRNOP00000022486; ENSRNOG00000016790.
    GeneIDi361688.
    KEGGirno:361688.
    UCSCiRGD:1311637. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03001123 Genomic DNA. No translation available.
    RefSeqi NP_001101982.1. NM_001108512.1.
    XP_006230893.1. XM_006230831.1.
    XP_006230894.1. XM_006230832.1.
    UniGenei Rn.203473.

    3D structure databases

    ProteinModelPortali P0C2N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022486.

    PTM databases

    PhosphoSitei P0C2N5.

    Proteomic databases

    PaxDbi P0C2N5.
    PRIDEi P0C2N5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022486 ; ENSRNOP00000022486 ; ENSRNOG00000016790 .
    GeneIDi 361688.
    KEGGi rno:361688.
    UCSCi RGD:1311637. rat.

    Organism-specific databases

    CTDi 51111.
    RGDi 1311637. Suv420h1.

    Phylogenomic databases

    eggNOGi NOG325204.
    GeneTreei ENSGT00520000055640.
    HOVERGENi HBG105761.
    InParanoidi P0C2N5.
    KOi K11429.
    OMAi KLEMGNL.
    OrthoDBi EOG7MKW6P.
    PhylomeDBi P0C2N5.
    TreeFami TF106433.

    Miscellaneous databases

    NextBioi 677253.
    PROi P0C2N5.

    Gene expression databases

    Genevestigatori P0C2N5.

    Family and domain databases

    InterProi IPR025790. Hist-Lys_N-MTase_Suvar4-20.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51570. SAM_MT43_SUVAR420_2. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiSV421_RAT
    AccessioniPrimary (citable) accession number: P0C2N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3