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P0C2N5

- SV421_RAT

UniProt

P0C2N5 - SV421_RAT

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Protein
Histone-lysine N-methyltransferase SUV420H1
Gene
Suv420h1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H4-K20 specific) Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. histone H4-K20 trimethylation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV420H1 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 4-20 homolog 1
Short name:
Su(var)4-20 homolog 1
Short name:
Suv4-20h1
Gene namesi
Name:Suv420h1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1311637. Suv420h1.

Subcellular locationi

Nucleus. Chromosome By similarity
Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin By similarity.

GO - Cellular componenti

  1. condensed nuclear chromosome, centromeric region Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 883883Histone-lysine N-methyltransferase SUV420H1
PRO_0000281789Add
BLAST

Proteomic databases

PaxDbiP0C2N5.
PRIDEiP0C2N5.

PTM databases

PhosphoSiteiP0C2N5.

Expressioni

Gene expression databases

GenevestigatoriP0C2N5.

Interactioni

Subunit structurei

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022486.

Structurei

3D structure databases

ProteinModelPortaliP0C2N5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 308116SET
Add
BLAST

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiNOG325204.
GeneTreeiENSGT00520000055640.
HOVERGENiHBG105761.
InParanoidiP0C2N5.
KOiK11429.
OMAiKLEMGNL.
OrthoDBiEOG7MKW6P.
PhylomeDBiP0C2N5.
TreeFamiTF106433.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C2N5-1 [UniParc]FASTAAdd to Basket

« Hide

MKWLGDSKNM VVNGRRNGSK LSNDHQQNQS KLQHAGKDAL KTGRNAVERR    50
PNRCHGNSGF EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM 100
NTSAFPSRSS RHISKADSFS HNNPMRFRPI KGRQEELKEV IERFKKDEHL 150
EKAFKCLTSG EWARHYFLNK NKMQEKLFKE HVFIYLRMFA TDSGFEILPC 200
NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN MLLRHGENDF 250
SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 300
EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG 350
LRETDKRLNR LKKLGDSSKS SDSQSVSSNT DADTTQEKDN ATSNRKSSVG 400
VKKNSKSRAL TRQSMPRVPA ASNSTSPKLV HMNNSRVPKK LRKPAKPLLS 450
KIKLRNHCKR LDQKSTSRKL EMGNLVLKEP KVVLYKNLPI KKEREAEGPV 500
HAAVGSGCLT RHAAREHRQN PGRGAHSQGD SLPCTYTTRR SLRTRTGLKE 550
TTDIKLAPSP LDGYKNGILE PYPDSGQQPT PEVLEELAPE TALREEASQE 600
CPKSDSCPSR KKFRQGKPVK HLAKTEDCSP EHSFPGKDGL PDLPGPHPDQ 650
GEPSGTVRVP VSYTDSAPSP VGCSIVTPDS FTTKDSFRTA QSKKKRRVTR 700
YDAQLILENS SGIPKLTLRR RHDSSSKTND HESDSVNSSK ISIKLSKDHE 750
SDSNLYVAKL SNGVSSGPGS SSTKLKIQLK RDEESRGPCA EGLHENGVCC 800
SDPLSLLESQ MEVDDYSQYE EDSTDDSSSS EGEEEEEDCE DDFDDDFIPL 850
PPAKRLRLIV GKDSIDIDIS SRRREDQSLR LNA 883
Length:883
Mass (Da):98,668
Last modified:April 3, 2007 - v1
Checksum:i1C5EAE2B39D2542F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03001123 Genomic DNA. No translation available.
RefSeqiNP_001101982.1. NM_001108512.1.
XP_006230893.1. XM_006230831.1.
XP_006230894.1. XM_006230832.1.
UniGeneiRn.203473.

Genome annotation databases

EnsembliENSRNOT00000022486; ENSRNOP00000022486; ENSRNOG00000016790.
GeneIDi361688.
KEGGirno:361688.
UCSCiRGD:1311637. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03001123 Genomic DNA. No translation available.
RefSeqi NP_001101982.1. NM_001108512.1.
XP_006230893.1. XM_006230831.1.
XP_006230894.1. XM_006230832.1.
UniGenei Rn.203473.

3D structure databases

ProteinModelPortali P0C2N5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022486.

PTM databases

PhosphoSitei P0C2N5.

Proteomic databases

PaxDbi P0C2N5.
PRIDEi P0C2N5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022486 ; ENSRNOP00000022486 ; ENSRNOG00000016790 .
GeneIDi 361688.
KEGGi rno:361688.
UCSCi RGD:1311637. rat.

Organism-specific databases

CTDi 51111.
RGDi 1311637. Suv420h1.

Phylogenomic databases

eggNOGi NOG325204.
GeneTreei ENSGT00520000055640.
HOVERGENi HBG105761.
InParanoidi P0C2N5.
KOi K11429.
OMAi KLEMGNL.
OrthoDBi EOG7MKW6P.
PhylomeDBi P0C2N5.
TreeFami TF106433.

Miscellaneous databases

NextBioi 677253.
PROi P0C2N5.

Gene expression databases

Genevestigatori P0C2N5.

Family and domain databases

InterProi IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiSV421_RAT
AccessioniPrimary (citable) accession number: P0C2N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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