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Protein

Phosphate-binding protein PstS 2

Gene

pstS2

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex PstSACB involved in phosphate import.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphate transport, Stress response, Transport

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-2145-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate-binding protein PstS 2
Short name:
PBP 2
Gene namesi
Name:pstS2
Ordered Locus Names:SP_2084
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121PROSITE-ProRule annotationAdd
BLAST
Chaini22 – 291270Phosphate-binding protein PstS 2PRO_0000281671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi22 – 221S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Expressioni

Inductioni

By phosphate starvation.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).Curated

Protein-protein interaction databases

STRINGi170187.SP_2084.

Structurei

Secondary structure

1
291
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 425Combined sources
Helixi47 – 559Combined sources
Beta strandi59 – 646Combined sources
Beta strandi66 – 683Combined sources
Beta strandi75 – 795Combined sources
Helixi80 – 8910Combined sources
Beta strandi93 – 986Combined sources
Helixi99 – 1013Combined sources
Beta strandi106 – 1083Combined sources
Helixi118 – 1225Combined sources
Beta strandi128 – 1369Combined sources
Helixi142 – 15211Combined sources
Helixi154 – 1629Combined sources
Beta strandi181 – 1888Combined sources
Helixi190 – 20617Combined sources
Beta strandi209 – 2179Combined sources
Helixi219 – 2279Combined sources
Beta strandi232 – 2387Combined sources
Helixi242 – 2454Combined sources
Beta strandi249 – 26214Combined sources
Helixi273 – 2808Combined sources
Helixi287 – 2893Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H1XX-ray1.77A28-291[»]
ProteinModelPortaliP0C2M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PstS family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107S17. Bacteria.
COG0226. LUCA.
HOGENOMiHOG000245546.
KOiK02040.
OMAiNIVWSSD.
OrthoDBiEOG6BS8T4.

Family and domain databases

InterProiIPR024370. PBP_domain.
[Graphical view]
PfamiPF12849. PBP_like_2. 2 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKKMLTLA AIGLSGFGLV ACGNQSAASK QSASGTIEVI SRENGSGTRG
60 70 80 90 100
AFTEITGILK KDGDKKIDNT AKTAVIQNST EGVLSAVQGN ANAIGYISLG
110 120 130 140 150
SLTKSVKALE IDGVKASRDT VLDGEYPLQR PFNIVWSSNL SKLGQDFISF
160 170 180 190 200
IHSKQGQQVV TDNKFIEAKT ETTEYTSQHL SGKLSVVGST SVSSLMEKLA
210 220 230 240 250
EAYKKENPEV TIDITSNGSS AGITAVKEKT ADIGMVSREL TPEEGKSLTH
260 270 280 290
DAIALDGIAV VVNNDNKASQ VSMAELADVF SGKLTTWDKI K
Length:291
Mass (Da):30,757
Last modified:March 20, 2007 - v1
Checksum:i4F534005A7DDE616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039745 Genomic DNA. Translation: AAK72111.1.
AE005672 Genomic DNA. Translation: AAK76144.1.
PIRiG95243.
RefSeqiWP_000669493.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK76144; AAK76144; SP_2084.
KEGGispn:SP_2084.
PATRICi19708753. VBIStrPne105772_2167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039745 Genomic DNA. Translation: AAK72111.1.
AE005672 Genomic DNA. Translation: AAK76144.1.
PIRiG95243.
RefSeqiWP_000669493.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H1XX-ray1.77A28-291[»]
ProteinModelPortaliP0C2M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_2084.

Protocols and materials databases

DNASUi931962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76144; AAK76144; SP_2084.
KEGGispn:SP_2084.
PATRICi19708753. VBIStrPne105772_2167.

Phylogenomic databases

eggNOGiENOG4107S17. Bacteria.
COG0226. LUCA.
HOGENOMiHOG000245546.
KOiK02040.
OMAiNIVWSSD.
OrthoDBiEOG6BS8T4.

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-2145-MONOMER.

Family and domain databases

InterProiIPR024370. PBP_domain.
[Graphical view]
PfamiPF12849. PBP_like_2. 2 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Streptococcus pneumoniae PstS production is phosphate responsive and enhanced during growth in the murine peritoneal cavity."
    Orihuela C.J., Mills J., Robb C.W., Wilson C.J., Watson D.A., Niesel D.W.
    Infect. Immun. 69:7565-7571(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: WU2 / Serotype 3.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  3. "A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter."
    Soualhine H., Brochu V., Menard F., Papadopoulou B., Weiss K., Bergeron M.G., Legare D., Drummelsmith J., Ouellette M.
    Mol. Microbiol. 58:1430-1440(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN PENICILLIN RESISTANCE.

Entry informationi

Entry nameiPSTS2_STRPN
AccessioniPrimary (citable) accession number: P0C2M5
Secondary accession number(s): Q7D480, Q9X4T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression seems to confer resistance to penicillin.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.