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Protein

Phosphate-binding protein PstS 2

Gene

pstS2

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex PstSACB involved in phosphate import.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphate transport, Stress response, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate-binding protein PstS 2
Short name:
PBP 2
Gene namesi
Name:pstS2
Ordered Locus Names:SP_2084
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21PROSITE-ProRule annotationAdd BLAST21
ChainiPRO_000028167122 – 291Phosphate-binding protein PstS 2Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi22S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Expressioni

Inductioni

By phosphate starvation.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).Curated

Protein-protein interaction databases

STRINGi170187.SP_2084.

Structurei

Secondary structure

1291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 42Combined sources5
Helixi47 – 55Combined sources9
Beta strandi59 – 64Combined sources6
Beta strandi66 – 68Combined sources3
Beta strandi75 – 79Combined sources5
Helixi80 – 89Combined sources10
Beta strandi93 – 98Combined sources6
Helixi99 – 101Combined sources3
Beta strandi106 – 108Combined sources3
Helixi118 – 122Combined sources5
Beta strandi128 – 136Combined sources9
Helixi142 – 152Combined sources11
Helixi154 – 162Combined sources9
Beta strandi181 – 188Combined sources8
Helixi190 – 206Combined sources17
Beta strandi209 – 217Combined sources9
Helixi219 – 227Combined sources9
Beta strandi232 – 238Combined sources7
Helixi242 – 245Combined sources4
Beta strandi249 – 262Combined sources14
Helixi273 – 280Combined sources8
Helixi287 – 289Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H1XX-ray1.77A28-291[»]
ProteinModelPortaliP0C2M5.
SMRiP0C2M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PstS family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107S17. Bacteria.
COG0226. LUCA.
HOGENOMiHOG000245546.
KOiK02040.
OMAiNIVWSSD.

Family and domain databases

InterProiIPR024370. PBP_domain.
[Graphical view]
PfamiPF12849. PBP_like_2. 2 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKKMLTLA AIGLSGFGLV ACGNQSAASK QSASGTIEVI SRENGSGTRG
60 70 80 90 100
AFTEITGILK KDGDKKIDNT AKTAVIQNST EGVLSAVQGN ANAIGYISLG
110 120 130 140 150
SLTKSVKALE IDGVKASRDT VLDGEYPLQR PFNIVWSSNL SKLGQDFISF
160 170 180 190 200
IHSKQGQQVV TDNKFIEAKT ETTEYTSQHL SGKLSVVGST SVSSLMEKLA
210 220 230 240 250
EAYKKENPEV TIDITSNGSS AGITAVKEKT ADIGMVSREL TPEEGKSLTH
260 270 280 290
DAIALDGIAV VVNNDNKASQ VSMAELADVF SGKLTTWDKI K
Length:291
Mass (Da):30,757
Last modified:March 20, 2007 - v1
Checksum:i4F534005A7DDE616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039745 Genomic DNA. Translation: AAK72111.1.
AE005672 Genomic DNA. Translation: AAK76144.1.
PIRiG95243.
RefSeqiWP_000669493.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK76144; AAK76144; SP_2084.
KEGGispn:SP_2084.
PATRICi19708753. VBIStrPne105772_2167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039745 Genomic DNA. Translation: AAK72111.1.
AE005672 Genomic DNA. Translation: AAK76144.1.
PIRiG95243.
RefSeqiWP_000669493.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H1XX-ray1.77A28-291[»]
ProteinModelPortaliP0C2M5.
SMRiP0C2M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_2084.

Protocols and materials databases

DNASUi931962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76144; AAK76144; SP_2084.
KEGGispn:SP_2084.
PATRICi19708753. VBIStrPne105772_2167.

Phylogenomic databases

eggNOGiENOG4107S17. Bacteria.
COG0226. LUCA.
HOGENOMiHOG000245546.
KOiK02040.
OMAiNIVWSSD.

Family and domain databases

InterProiIPR024370. PBP_domain.
[Graphical view]
PfamiPF12849. PBP_like_2. 2 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSTS2_STRPN
AccessioniPrimary (citable) accession number: P0C2M5
Secondary accession number(s): Q7D480, Q9X4T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression seems to confer resistance to penicillin.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.