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P0C2J9

- TACY_STRPN

UniProt

P0C2J9 - TACY_STRPN

Protein

Pneumolysin

Gene

ply

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei428 – 4281Binding to cholesterolBy similarity

    GO - Molecular functioni

    1. cholesterol binding Source: InterPro

    GO - Biological processi

    1. hemolysis in other organism Source: UniProtKB-KW
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Toxin

    Keywords - Biological processi

    Cytolysis, Hemolysis

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-1953-MONOMER.

    Protein family/group databases

    TCDBi1.C.12.1.5. thiol-activated cholesterol-dependent cytolysin (cdc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pneumolysin
    Alternative name(s):
    Thiol-activated cytolysin
    Gene namesi
    Name:ply
    Ordered Locus Names:SP_1923
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    Subcellular locationi

    Secreted By similarity. Host cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Secreted as soluble protein that then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands.By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 471470PneumolysinPRO_0000204251Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomeric pore complex; when inserted in the host membrane.By similarity

    Protein-protein interaction databases

    STRINGi170187.SP_1923.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C2J9.
    SMRiP0C2J9. Positions 2-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiol-activated cytolysin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG04845.
    HOGENOMiHOG000056095.
    KOiK11031.
    OMAiANRTYPG.
    OrthoDBiEOG6S7XT6.

    Family and domain databases

    Gene3Di3.90.840.10. 4 hits.
    InterProiIPR001869. Thiol_cytolysin.
    [Graphical view]
    PfamiPF01289. Thiol_cytolysin. 1 hit.
    [Graphical view]
    PRINTSiPR01400. TACYTOLYSIN.
    SUPFAMiSSF56978. SSF56978. 1 hit.
    PROSITEiPS00481. THIOL_CYTOLYSINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C2J9-1 [UniParc]FASTAAdd to Basket

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    MANKAVNDFI LAMNYDKKKL LTHQGESIEN RFIKEGNQLP DEFVVIERKK    50
    RSLSTNTSDI SVTATNDSRL YPGALLVVDE TLLENNPTLL AVDRAPMTYS 100
    IDLPGLASSD SFLQVEDPSN SSVRGAVNDL LAKWHQDYGQ VNNVPARMQY 150
    EKITAHSMEQ LKVKFGSDFE KTGNSLDIDF NSVHSGEKQI QIVNFKQIYY 200
    TVSVDAVKNP GDVFQDTVTV EDLKQRGISA ERPLVYISSV AYGRQVYLKL 250
    ETTSKSDEVE AAFEALIKGV KVAPQTEWKQ ILDNTEVKAV ILGGDPSSGA 300
    RVVTGKVDMV EDLIQEGSRF TADHPGLPIS YTTSFLRDNV VATFQNSTDY 350
    VETKVTAYRN GDLLLDHSGA YVAQYYITWN ELSYDHQGKE VLTPKAWDRN 400
    GQDLTAHFTT SIPLKGNVRN LSVKIRECTG LAWEWWRTVY EKTDLPLVRK 450
    RTISIWGTTL YPQVEDKVEN D 471
    Length:471
    Mass (Da):52,898
    Last modified:March 6, 2007 - v1
    Checksum:i986A146548E0F738
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75991.1.
    PIRiA28568.
    A99089.
    RefSeqiNP_346351.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK75991; AAK75991; SP_1923.
    GeneIDi931915.
    KEGGispn:SP_1923.
    PATRICi19708367. VBIStrPne105772_2005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75991.1 .
    PIRi A28568.
    A99089.
    RefSeqi NP_346351.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali P0C2J9.
    SMRi P0C2J9. Positions 2-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_1923.

    Chemistry

    ChEMBLi CHEMBL5117.

    Protein family/group databases

    TCDBi 1.C.12.1.5. thiol-activated cholesterol-dependent cytolysin (cdc) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK75991 ; AAK75991 ; SP_1923 .
    GeneIDi 931915.
    KEGGi spn:SP_1923.
    PATRICi 19708367. VBIStrPne105772_2005.

    Phylogenomic databases

    eggNOGi NOG04845.
    HOGENOMi HOG000056095.
    KOi K11031.
    OMAi ANRTYPG.
    OrthoDBi EOG6S7XT6.

    Enzyme and pathway databases

    BioCyci SPNE170187:GHGN-1953-MONOMER.

    Family and domain databases

    Gene3Di 3.90.840.10. 4 hits.
    InterProi IPR001869. Thiol_cytolysin.
    [Graphical view ]
    Pfami PF01289. Thiol_cytolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR01400. TACYTOLYSIN.
    SUPFAMi SSF56978. SSF56978. 1 hit.
    PROSITEi PS00481. THIOL_CYTOLYSINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiTACY_STRPN
    AccessioniPrimary (citable) accession number: P0C2J9
    Secondary accession number(s): P11990
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3