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P0C2J9

- TACY_STRPN

UniProt

P0C2J9 - TACY_STRPN

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Protein

Pneumolysin

Gene

ply

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei428 – 4281Binding to cholesterolBy similarity

GO - Molecular functioni

  1. cholesterol binding Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1953-MONOMER.

Protein family/group databases

TCDBi1.C.12.1.5. thiol-activated cholesterol-dependent cytolysin (cdc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pneumolysin
Alternative name(s):
Thiol-activated cytolysin
Gene namesi
Name:ply
Ordered Locus Names:SP_1923
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Secreted By similarity. Host cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Secreted as soluble protein that then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands.By similarity

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 471470PneumolysinPRO_0000204251Add
BLAST

Interactioni

Subunit structurei

Homooligomeric pore complex; when inserted in the host membrane.By similarity

Protein-protein interaction databases

STRINGi170187.SP_1923.

Structurei

3D structure databases

ProteinModelPortaliP0C2J9.
SMRiP0C2J9. Positions 2-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiol-activated cytolysin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG04845.
HOGENOMiHOG000056095.
KOiK11031.
OMAiANRTYPG.
OrthoDBiEOG6S7XT6.

Family and domain databases

Gene3Di3.90.840.10. 4 hits.
InterProiIPR001869. Thiol_cytolysin.
[Graphical view]
PfamiPF01289. Thiol_cytolysin. 1 hit.
[Graphical view]
PRINTSiPR01400. TACYTOLYSIN.
SUPFAMiSSF56978. SSF56978. 1 hit.
PROSITEiPS00481. THIOL_CYTOLYSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2J9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKAVNDFI LAMNYDKKKL LTHQGESIEN RFIKEGNQLP DEFVVIERKK
60 70 80 90 100
RSLSTNTSDI SVTATNDSRL YPGALLVVDE TLLENNPTLL AVDRAPMTYS
110 120 130 140 150
IDLPGLASSD SFLQVEDPSN SSVRGAVNDL LAKWHQDYGQ VNNVPARMQY
160 170 180 190 200
EKITAHSMEQ LKVKFGSDFE KTGNSLDIDF NSVHSGEKQI QIVNFKQIYY
210 220 230 240 250
TVSVDAVKNP GDVFQDTVTV EDLKQRGISA ERPLVYISSV AYGRQVYLKL
260 270 280 290 300
ETTSKSDEVE AAFEALIKGV KVAPQTEWKQ ILDNTEVKAV ILGGDPSSGA
310 320 330 340 350
RVVTGKVDMV EDLIQEGSRF TADHPGLPIS YTTSFLRDNV VATFQNSTDY
360 370 380 390 400
VETKVTAYRN GDLLLDHSGA YVAQYYITWN ELSYDHQGKE VLTPKAWDRN
410 420 430 440 450
GQDLTAHFTT SIPLKGNVRN LSVKIRECTG LAWEWWRTVY EKTDLPLVRK
460 470
RTISIWGTTL YPQVEDKVEN D
Length:471
Mass (Da):52,898
Last modified:March 6, 2007 - v1
Checksum:i986A146548E0F738
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75991.1.
PIRiA28568.
A99089.
RefSeqiNP_346351.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75991; AAK75991; SP_1923.
GeneIDi931915.
KEGGispn:SP_1923.
PATRICi19708367. VBIStrPne105772_2005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75991.1 .
PIRi A28568.
A99089.
RefSeqi NP_346351.1. NC_003028.3.

3D structure databases

ProteinModelPortali P0C2J9.
SMRi P0C2J9. Positions 2-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1923.

Chemistry

ChEMBLi CHEMBL5117.

Protein family/group databases

TCDBi 1.C.12.1.5. thiol-activated cholesterol-dependent cytolysin (cdc) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75991 ; AAK75991 ; SP_1923 .
GeneIDi 931915.
KEGGi spn:SP_1923.
PATRICi 19708367. VBIStrPne105772_2005.

Phylogenomic databases

eggNOGi NOG04845.
HOGENOMi HOG000056095.
KOi K11031.
OMAi ANRTYPG.
OrthoDBi EOG6S7XT6.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1953-MONOMER.

Family and domain databases

Gene3Di 3.90.840.10. 4 hits.
InterProi IPR001869. Thiol_cytolysin.
[Graphical view ]
Pfami PF01289. Thiol_cytolysin. 1 hit.
[Graphical view ]
PRINTSi PR01400. TACYTOLYSIN.
SUPFAMi SSF56978. SSF56978. 1 hit.
PROSITEi PS00481. THIOL_CYTOLYSINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiTACY_STRPN
AccessioniPrimary (citable) accession number: P0C2J9
Secondary accession number(s): P11990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3