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P0C2I4

- YH11A_YEAST

UniProt

P0C2I4 - YH11A_YEAST

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Protein

Transposon Ty1-H Gag polyprotein

Gene
TY1A-H, YHRCTy1-1 GAG, YHR214C-C, YHR214C-A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei439 – 4402Cleavage; by Ty1 protease By similarity

GO - Molecular functioni

  1. RNA binding Source: SGD

GO - Biological processi

  1. transposition, RNA-mediated Source: SGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transposon Ty1-H Gag polyprotein
Alternative name(s):
Gag-p49
Transposon Ty1 protein A
Short name:
TY1A
Short name:
TYA
p58
Cleaved into the following 2 chains:
Capsid protein
Short name:
CA
Alternative name(s):
Gag-p45
p54
Gene namesi
Name:TY1A-H
Synonyms:YHRCTy1-1 GAG
Ordered Locus Names:YHR214C-C
ORF Names:YHR214C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

SGDiS000007421. YHR214C-C.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. retrotransposon nucleocapsid Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Transposon Ty1-H Gag polyproteinPRO_0000279079Add
BLAST
Chaini1 – 439439Capsid protein By similarityPRO_0000279080Add
BLAST
Peptidei440 – 47839Gag-p4 By similarityPRO_0000279081Add
BLAST

Proteomic databases

MaxQBiP0C2I4.

Expressioni

Gene expression databases

GenevestigatoriP0C2I4.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

BioGridi36649. 14 interactions.
STRINGi4932.YHR214C-C.

Structurei

3D structure databases

ProteinModelPortaliP0C2I4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 439103RNA-binding By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi72 – 14675Pro-richAdd
BLAST

Domaini

The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities By similarity.

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00750000117913.
HOGENOMiHOG000000740.
OrthoDBiEOG7TJ3S3.

Family and domain databases

InterProiIPR015820. Retrotransposon_Ty1A_N.
[Graphical view]
PfamiPF01021. TYA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Note: The Gag-Pol polyprotein is generated by a +1 ribosomal frameshift. The ratio of Gag:Gag-Pol varies between 20:1 and 5:1 (By similarity).

Isoform Transposon Ty1-H Gag polyprotein (identifier: P0C2I4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESQQLSNYP HISHGSACAS VTSKEVHTNQ DPLDVSASKI QEYDKASTKA    50
NSQQTTTPAS SAVPENLHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG 100
WSFYGHPSMI PYTPYQMSPM YFPPGPQSQF PQYPSSVGTP LSTPSPESGN 150
TFTDSSSADS DMTSTKKYVR PPPMLTSPND FPNWVKTYIK FLQNSNLGGI 200
IPTVNGKPVP PMLTSPNDFP NWVKTYIKFL QNSNLGGIIP TVNGKPVRQI 250
TDDELTFLYN TFQIFAPSQF LPTWVKDILS VDYTDIMKIL SKSIEKMQSD 300
TQEANDIVTL ANLQYNGSTP ADAFETKVTN IIDRLNNNGI HINNKVACQL 350
IMRGLSGEYK FLRYTRHRHL NMTVAELFLD IHAIYEEQQG SRNSKPNYRR 400
NPSDEKNDSR SYTNTTKPKV IARNPQKTNN SKSKTARAHN VSTSNNSPST 450
DNDSISKSTT EPIQLNNKHD LHLRPETY 478

Note: Produced by conventional translation.

Length:478
Mass (Da):53,325
Last modified:March 6, 2007 - v1
Checksum:i2A0E36FEFE4B66B9
GO
Isoform Transposon Ty1-H Gag-Pol polyprotein (identifier: O13535-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry O13535.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YHR214C-C ORF.

Length:1,793
Mass (Da):202,817
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. No translation available.
BK006934 Genomic DNA. Translation: DAA06911.1.
PIRiS52602.
RefSeqiNP_036195.3. NM_001184437.3. [P0C2I4-1]

Genome annotation databases

EnsemblFungiiYHR214C-C; YHR214C-C; YHR214C-C. [P0C2I4-1]
GeneIDi856624.
KEGGisce:YHR214C-C.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. No translation available.
BK006934 Genomic DNA. Translation: DAA06911.1 .
PIRi S52602.
RefSeqi NP_036195.3. NM_001184437.3. [P0C2I4-1 ]

3D structure databases

ProteinModelPortali P0C2I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36649. 14 interactions.
STRINGi 4932.YHR214C-C.

Proteomic databases

MaxQBi P0C2I4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR214C-C ; YHR214C-C ; YHR214C-C . [P0C2I4-1 ]
GeneIDi 856624.
KEGGi sce:YHR214C-C.

Organism-specific databases

SGDi S000007421. YHR214C-C.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00750000117913.
HOGENOMi HOG000000740.
OrthoDBi EOG7TJ3S3.

Miscellaneous databases

NextBioi 982562.

Gene expression databases

Genevestigatori P0C2I4.

Family and domain databases

InterProi IPR015820. Retrotransposon_Ty1A_N.
[Graphical view ]
Pfami PF01021. TYA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence."
    Kim J.M., Vanguri S., Boeke J.D., Gabriel A., Voytas D.F.
    Genome Res. 8:464-478(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  4. "Happy together: the life and times of Ty retrotransposons and their hosts."
    Lesage P., Todeschini A.L.
    Cytogenet. Genome Res. 110:70-90(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiYH11A_YEAST
AccessioniPrimary (citable) accession number: P0C2I4
Secondary accession number(s): D3DLG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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