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Protein

60S ribosomal protein L31-A

Gene

RPL31A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. regulation of translational fidelity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29486-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L31-A
Alternative name(s):
L34
YL28
Gene namesi
Name:RPL31A
Synonyms:RPL34, RPL34A
Ordered Locus Names:YDL075W
ORF Names:D2478
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

SGDiS000002233. RPL31A.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 11311260S ribosomal protein L31-APRO_0000153788Add
BLAST

Proteomic databases

MaxQBiP0C2H8.
PeptideAtlasiP0C2H8.
PRIDEiP0C2H8.

Expressioni

Gene expression databases

ExpressionAtlasiP0C2H8. differential.
GenevestigatoriP0C2H8.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31986. 111 interactions.
DIPiDIP-5135N.
IntActiP0C2H8. 1 interaction.
MINTiMINT-8285615.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Helixi16 – 205Combined sources
Turni25 – 273Combined sources
Helixi28 – 4417Combined sources
Beta strandi49 – 513Combined sources
Helixi53 – 608Combined sources
Helixi64 – 663Combined sources
Beta strandi69 – 7911Combined sources
Beta strandi86 – 9510Combined sources
Beta strandi101 – 1033Combined sources
Beta strandi107 – 1093Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-W6-83[»]
2WW9electron microscopy8.60M1-113[»]
2WWAelectron microscopy8.90M1-113[»]
2WWBelectron microscopy6.48M1-113[»]
3J6Xelectron microscopy6.10711-113[»]
3J6Yelectron microscopy6.10711-113[»]
3J77electron microscopy6.20811-113[»]
3J78electron microscopy6.30811-113[»]
4U3MX-ray3.00O1/o12-113[»]
4U3NX-ray3.20O1/o12-113[»]
4U3UX-ray2.90O1/o12-113[»]
4U4NX-ray3.10O1/o12-113[»]
4U4OX-ray3.60O1/o12-113[»]
4U4QX-ray3.00O1/o12-113[»]
4U4RX-ray2.80O1/o12-113[»]
4U4UX-ray3.00O1/o12-113[»]
4U4YX-ray3.20O1/o12-113[»]
4U4ZX-ray3.10O1/o12-113[»]
4U50X-ray3.20O1/o12-113[»]
4U51X-ray3.20O1/o12-113[»]
4U52X-ray3.00O1/o12-113[»]
4U53X-ray3.30O1/o12-113[»]
4U55X-ray3.20O1/o12-113[»]
4U56X-ray3.45O1/o12-113[»]
4U6FX-ray3.10O1/o12-113[»]
4V4Belectron microscopy11.70BW2-113[»]
4V6Ielectron microscopy8.80Bg1-113[»]
4V7Felectron microscopy8.70c1-113[»]
4V7RX-ray4.00Ba/Da1-113[»]
4V88X-ray3.00Bd/Dd1-113[»]
4V8Telectron microscopy8.10d1-113[»]
4V8Yelectron microscopy4.30Bd2-113[»]
4V8Zelectron microscopy6.60Bd2-113[»]
4V91electron microscopy3.70d1-113[»]
ProteinModelPortaliP0C2H8.
SMRiP0C2H8. Positions 4-112.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2H8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L31e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005200.
HOGENOMiHOG000216660.
InParanoidiP0C2H8.
KOiK02910.
OMAiLWERGIK.
OrthoDBiEOG7X0VW7.

Family and domain databases

Gene3Di3.10.440.10. 1 hit.
InterProiIPR000054. Ribosomal_L31e.
IPR020052. Ribosomal_L31e_CS.
IPR023621. Ribosomal_L31e_dom.
[Graphical view]
PANTHERiPTHR10956. PTHR10956. 1 hit.
PfamiPF01198. Ribosomal_L31e. 1 hit.
[Graphical view]
ProDomiPD006030. Ribosomal_L31e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54575. SSF54575. 1 hit.
PROSITEiPS01144. RIBOSOMAL_L31E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKDVVTR EYTINLHKRL HGVSFKKRAP RAVKEIKKFA KLHMGTDDVR
60 70 80 90 100
LAPELNQAIW KRGVKGVEYR LRLRISRKRN EEEDAKNPLF SYVEPVLVAS
110
AKGLQTVVVE EDA
Length:113
Mass (Da):12,953
Last modified:March 6, 2007 - v1
Checksum:i351B5ADD15DB3B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01441 Genomic DNA. Translation: CAA25679.1.
Z74123 Genomic DNA. Translation: CAA98641.1.
BK006938 Genomic DNA. Translation: DAA11784.1.
PIRiS67611. R5BY1E.
RefSeqiNP_010208.1. NM_001180134.1.

Genome annotation databases

EnsemblFungiiYDL075W; YDL075W; YDL075W.
GeneIDi851484.
KEGGisce:YDL075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01441 Genomic DNA. Translation: CAA25679.1.
Z74123 Genomic DNA. Translation: CAA98641.1.
BK006938 Genomic DNA. Translation: DAA11784.1.
PIRiS67611. R5BY1E.
RefSeqiNP_010208.1. NM_001180134.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-W6-83[»]
2WW9electron microscopy8.60M1-113[»]
2WWAelectron microscopy8.90M1-113[»]
2WWBelectron microscopy6.48M1-113[»]
3J6Xelectron microscopy6.10711-113[»]
3J6Yelectron microscopy6.10711-113[»]
3J77electron microscopy6.20811-113[»]
3J78electron microscopy6.30811-113[»]
4U3MX-ray3.00O1/o12-113[»]
4U3NX-ray3.20O1/o12-113[»]
4U3UX-ray2.90O1/o12-113[»]
4U4NX-ray3.10O1/o12-113[»]
4U4OX-ray3.60O1/o12-113[»]
4U4QX-ray3.00O1/o12-113[»]
4U4RX-ray2.80O1/o12-113[»]
4U4UX-ray3.00O1/o12-113[»]
4U4YX-ray3.20O1/o12-113[»]
4U4ZX-ray3.10O1/o12-113[»]
4U50X-ray3.20O1/o12-113[»]
4U51X-ray3.20O1/o12-113[»]
4U52X-ray3.00O1/o12-113[»]
4U53X-ray3.30O1/o12-113[»]
4U55X-ray3.20O1/o12-113[»]
4U56X-ray3.45O1/o12-113[»]
4U6FX-ray3.10O1/o12-113[»]
4V4Belectron microscopy11.70BW2-113[»]
4V6Ielectron microscopy8.80Bg1-113[»]
4V7Felectron microscopy8.70c1-113[»]
4V7RX-ray4.00Ba/Da1-113[»]
4V88X-ray3.00Bd/Dd1-113[»]
4V8Telectron microscopy8.10d1-113[»]
4V8Yelectron microscopy4.30Bd2-113[»]
4V8Zelectron microscopy6.60Bd2-113[»]
4V91electron microscopy3.70d1-113[»]
ProteinModelPortaliP0C2H8.
SMRiP0C2H8. Positions 4-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31986. 111 interactions.
DIPiDIP-5135N.
IntActiP0C2H8. 1 interaction.
MINTiMINT-8285615.

Proteomic databases

MaxQBiP0C2H8.
PeptideAtlasiP0C2H8.
PRIDEiP0C2H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL075W; YDL075W; YDL075W.
GeneIDi851484.
KEGGisce:YDL075W.

Organism-specific databases

SGDiS000002233. RPL31A.

Phylogenomic databases

GeneTreeiENSGT00390000005200.
HOGENOMiHOG000216660.
InParanoidiP0C2H8.
KOiK02910.
OMAiLWERGIK.
OrthoDBiEOG7X0VW7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29486-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

EvolutionaryTraceiP0C2H8.
NextBioi968804.

Gene expression databases

ExpressionAtlasiP0C2H8. differential.
GenevestigatoriP0C2H8.

Family and domain databases

Gene3Di3.10.440.10. 1 hit.
InterProiIPR000054. Ribosomal_L31e.
IPR020052. Ribosomal_L31e_CS.
IPR023621. Ribosomal_L31e_dom.
[Graphical view]
PANTHERiPTHR10956. PTHR10956. 1 hit.
PfamiPF01198. Ribosomal_L31e. 1 hit.
[Graphical view]
ProDomiPD006030. Ribosomal_L31e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54575. SSF54575. 1 hit.
PROSITEiPS01144. RIBOSOMAL_L31E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of a gene encoding yeast ribosomal protein L34."
    Schaap P.J., Molenaar C.M.T., Mager W.H., Planta R.J.
    Curr. Genet. 9:47-52(1984)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Carlsbergensis.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
    Otaka E., Higo K., Itoh T.
    Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE OF 2-51, CLEAVAGE OF INITIATOR METHIONINE.
  5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE.
  6. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 6-83, ELECTRON MICROSCOPY.
  7. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
  8. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  9. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL31A_YEAST
AccessioniPrimary (citable) accession number: P0C2H8
Secondary accession number(s): D6VRS4, P04649, Q3E7B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: March 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L31 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.