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Protein

60S ribosomal protein L31-A

Gene

RPL31A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for eL31 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • regulation of translational fidelity Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29486-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L31-A1 Publication
Alternative name(s):
L34
Large ribosomal subunit protein eL31-A1 Publication
YL28
Gene namesi
Name:RPL31A1 Publication
Synonyms:RPL34, RPL34A
Ordered Locus Names:YDL075W
ORF Names:D2478
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL075W
SGDiS000002233 RPL31A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001537882 – 11360S ribosomal protein L31-AAdd BLAST112

Proteomic databases

MaxQBiP0C2H8
PaxDbiP0C2H8
PRIDEiP0C2H8
TopDownProteomicsiP0C2H8

PTM databases

CarbonylDBiP0C2H8
iPTMnetiP0C2H8

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31986, 59 interactors
DIPiDIP-5135N
IntActiP0C2H8, 1 interactor
MINTiP0C2H8
STRINGi4932.YDL075W

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 15Combined sources7
Helixi16 – 20Combined sources5
Turni25 – 27Combined sources3
Helixi28 – 44Combined sources17
Beta strandi49 – 51Combined sources3
Helixi53 – 60Combined sources8
Helixi64 – 66Combined sources3
Beta strandi69 – 79Combined sources11
Beta strandi86 – 95Combined sources10
Beta strandi101 – 103Combined sources3
Beta strandi107 – 109Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-W6-83[»]
2WW9electron microscopy8.60M1-113[»]
2WWAelectron microscopy8.90M1-113[»]
2WWBelectron microscopy6.48M1-113[»]
3J6Xelectron microscopy6.10711-113[»]
3J6Yelectron microscopy6.10711-113[»]
3J77electron microscopy6.20811-113[»]
3J78electron microscopy6.30811-113[»]
3JCTelectron microscopy3.08d1-113[»]
4U3MX-ray3.00O1/o12-113[»]
4U3NX-ray3.20O1/o12-113[»]
4U3UX-ray2.90O1/o12-113[»]
4U4NX-ray3.10O1/o12-113[»]
4U4OX-ray3.60O1/o12-113[»]
4U4QX-ray3.00O1/o12-113[»]
4U4RX-ray2.80O1/o12-113[»]
4U4UX-ray3.00O1/o12-113[»]
4U4YX-ray3.20O1/o12-113[»]
4U4ZX-ray3.10O1/o12-113[»]
4U50X-ray3.20O1/o12-113[»]
4U51X-ray3.20O1/o12-113[»]
4U52X-ray3.00O1/o12-113[»]
4U53X-ray3.30O1/o12-113[»]
4U55X-ray3.20O1/o12-113[»]
4U56X-ray3.45O1/o12-113[»]
4U6FX-ray3.10O1/o12-113[»]
4V4Belectron microscopy11.70BW2-113[»]
4V6Ielectron microscopy8.80Bg1-113[»]
4V7Felectron microscopy8.70c1-113[»]
4V7RX-ray4.00Ba/Da1-113[»]
4V88X-ray3.00Bd/Dd1-113[»]
4V8Telectron microscopy8.10d1-113[»]
4V8Yelectron microscopy4.30Bd2-113[»]
4V8Zelectron microscopy6.60Bd2-113[»]
4V91electron microscopy3.70d1-113[»]
5APNelectron microscopy3.91d1-113[»]
5APOelectron microscopy3.41d1-113[»]
5DATX-ray3.15O1/o12-113[»]
5DC3X-ray3.25O1/o12-113[»]
5DGEX-ray3.45O1/o12-113[»]
5DGFX-ray3.30O1/o12-113[»]
5DGVX-ray3.10O1/o12-113[»]
5FCIX-ray3.40O1/o12-113[»]
5FCJX-ray3.10O1/o12-113[»]
5FL8electron microscopy9.50d1-113[»]
5GAKelectron microscopy3.88f4-112[»]
5H4Pelectron microscopy3.07d1-113[»]
5I4LX-ray3.10O1/o14-112[»]
5JCSelectron microscopy9.50d1-113[»]
5JUOelectron microscopy4.00IA1-113[»]
5JUPelectron microscopy3.50IA1-113[»]
5JUSelectron microscopy4.20IA1-113[»]
5JUTelectron microscopy4.00IA1-113[»]
5JUUelectron microscopy4.00IA1-113[»]
5LYBX-ray3.25O1/o14-112[»]
5M1Jelectron microscopy3.30d54-112[»]
5MC6electron microscopy3.80BC1-113[»]
5MEIX-ray3.50AE/DF4-112[»]
5NDGX-ray3.70O1/o14-112[»]
5NDVX-ray3.30O1/o12-113[»]
5NDWX-ray3.70O1/o14-112[»]
5OBMX-ray3.40O1/o14-112[»]
5ON6X-ray3.10AE/DF4-112[»]
5T62electron microscopy3.30q1-113[»]
5T6Relectron microscopy4.50q1-113[»]
5TBWX-ray3.00AE/DF4-112[»]
5TGAX-ray3.30O1/o14-112[»]
5TGMX-ray3.50O1/o14-112[»]
6ELZelectron microscopy3.30d1-113[»]
6EM5electron microscopy4.30d1-113[»]
ProteinModelPortaliP0C2H8
SMRiP0C2H8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2H8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000005200
HOGENOMiHOG000216660
InParanoidiP0C2H8
KOiK02910
OMAiMTIHMHK
OrthoDBiEOG092C5QTG

Family and domain databases

CDDicd00463 Ribosomal_L31e, 1 hit
Gene3Di3.10.440.10, 1 hit
InterProiView protein in InterPro
IPR000054 Ribosomal_L31e
IPR020052 Ribosomal_L31e_CS
IPR023621 Ribosomal_L31e_dom_sf
PANTHERiPTHR10956 PTHR10956, 1 hit
PfamiView protein in Pfam
PF01198 Ribosomal_L31e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006030 Ribosomal_L31e, 1 hit
SMARTiView protein in SMART
SM01380 Ribosomal_L31e, 1 hit
SUPFAMiSSF54575 SSF54575, 1 hit
PROSITEiView protein in PROSITE
PS01144 RIBOSOMAL_L31E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKDVVTR EYTINLHKRL HGVSFKKRAP RAVKEIKKFA KLHMGTDDVR
60 70 80 90 100
LAPELNQAIW KRGVKGVEYR LRLRISRKRN EEEDAKNPLF SYVEPVLVAS
110
AKGLQTVVVE EDA
Length:113
Mass (Da):12,953
Last modified:March 6, 2007 - v1
Checksum:i351B5ADD15DB3B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01441 Genomic DNA Translation: CAA25679.1
Z74123 Genomic DNA Translation: CAA98641.1
BK006938 Genomic DNA Translation: DAA11784.1
PIRiS67611 R5BY1E
RefSeqiNP_010208.1, NM_001180134.1

Genome annotation databases

EnsemblFungiiYDL075W; YDL075W; YDL075W
GeneIDi851484
KEGGisce:YDL075W

Similar proteinsi

Entry informationi

Entry nameiRL31A_YEAST
AccessioniPrimary (citable) accession number: P0C2H8
Secondary accession number(s): D6VRS4, P04649, Q3E7B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health