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P0C2H8

- RL31A_YEAST

UniProt

P0C2H8 - RL31A_YEAST

Protein

60S ribosomal protein L31-A

Gene

RPL31A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. regulation of translational fidelity Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29486-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L31-A
    Alternative name(s):
    L34
    YL28
    Gene namesi
    Name:RPL31A
    Synonyms:RPL34, RPL34A
    Ordered Locus Names:YDL075W
    ORF Names:D2478
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    SGDiS000002233. RPL31A.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 11311260S ribosomal protein L31-APRO_0000153788Add
    BLAST

    Proteomic databases

    MaxQBiP0C2H8.
    PeptideAtlasiP0C2H8.
    PRIDEiP0C2H8.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C2H8.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31986. 109 interactions.
    DIPiDIP-5135N.
    IntActiP0C2H8. 1 interaction.
    MINTiMINT-8285615.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-W6-83[»]
    1S1Ielectron microscopy11.70W2-113[»]
    1VW8electron microscopy6.10e1-113[»]
    1VWUelectron microscopy6.10e1-113[»]
    2WW9electron microscopy8.60M1-113[»]
    2WWAelectron microscopy8.90M1-113[»]
    2WWBelectron microscopy6.48M1-113[»]
    3IZSelectron microscopy-g1-113[»]
    3J65electron microscopy8.70c1-113[»]
    3O58X-ray4.00a1-113[»]
    3O5HX-ray4.00a1-113[»]
    3U5EX-ray3.00d1-113[»]
    3U5IX-ray3.00d1-113[»]
    4B6Aelectron microscopy8.10d1-113[»]
    4BYNelectron microscopy4.30d2-113[»]
    4BYUelectron microscopy6.60d2-113[»]
    4CUWelectron microscopy3.70d1-113[»]
    ProteinModelPortaliP0C2H8.
    SMRiP0C2H8. Positions 4-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C2H8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L31e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000005200.
    HOGENOMiHOG000216660.
    KOiK02910.
    OMAiWRKEVIT.
    OrthoDBiEOG7X0VW7.

    Family and domain databases

    Gene3Di3.10.440.10. 1 hit.
    InterProiIPR000054. Ribosomal_L31e.
    IPR020052. Ribosomal_L31e_CS.
    IPR023621. Ribosomal_L31e_dom.
    [Graphical view]
    PANTHERiPTHR10956. PTHR10956. 1 hit.
    PfamiPF01198. Ribosomal_L31e. 1 hit.
    [Graphical view]
    ProDomiPD006030. Ribosomal_L31e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54575. SSF54575. 1 hit.
    PROSITEiPS01144. RIBOSOMAL_L31E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C2H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLKDVVTR EYTINLHKRL HGVSFKKRAP RAVKEIKKFA KLHMGTDDVR    50
    LAPELNQAIW KRGVKGVEYR LRLRISRKRN EEEDAKNPLF SYVEPVLVAS 100
    AKGLQTVVVE EDA 113
    Length:113
    Mass (Da):12,953
    Last modified:March 6, 2007 - v1
    Checksum:i351B5ADD15DB3B5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01441 Genomic DNA. Translation: CAA25679.1.
    Z74123 Genomic DNA. Translation: CAA98641.1.
    BK006938 Genomic DNA. Translation: DAA11784.1.
    PIRiS67611. R5BY1E.
    RefSeqiNP_010208.1. NM_001180134.1.

    Genome annotation databases

    EnsemblFungiiYDL075W; YDL075W; YDL075W.
    GeneIDi851484.
    KEGGisce:YDL075W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01441 Genomic DNA. Translation: CAA25679.1 .
    Z74123 Genomic DNA. Translation: CAA98641.1 .
    BK006938 Genomic DNA. Translation: DAA11784.1 .
    PIRi S67611. R5BY1E.
    RefSeqi NP_010208.1. NM_001180134.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - W 6-83 [» ]
    1S1I electron microscopy 11.70 W 2-113 [» ]
    1VW8 electron microscopy 6.10 e 1-113 [» ]
    1VWU electron microscopy 6.10 e 1-113 [» ]
    2WW9 electron microscopy 8.60 M 1-113 [» ]
    2WWA electron microscopy 8.90 M 1-113 [» ]
    2WWB electron microscopy 6.48 M 1-113 [» ]
    3IZS electron microscopy - g 1-113 [» ]
    3J65 electron microscopy 8.70 c 1-113 [» ]
    3O58 X-ray 4.00 a 1-113 [» ]
    3O5H X-ray 4.00 a 1-113 [» ]
    3U5E X-ray 3.00 d 1-113 [» ]
    3U5I X-ray 3.00 d 1-113 [» ]
    4B6A electron microscopy 8.10 d 1-113 [» ]
    4BYN electron microscopy 4.30 d 2-113 [» ]
    4BYU electron microscopy 6.60 d 2-113 [» ]
    4CUW electron microscopy 3.70 d 1-113 [» ]
    ProteinModelPortali P0C2H8.
    SMRi P0C2H8. Positions 4-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31986. 109 interactions.
    DIPi DIP-5135N.
    IntActi P0C2H8. 1 interaction.
    MINTi MINT-8285615.

    Proteomic databases

    MaxQBi P0C2H8.
    PeptideAtlasi P0C2H8.
    PRIDEi P0C2H8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL075W ; YDL075W ; YDL075W .
    GeneIDi 851484.
    KEGGi sce:YDL075W.

    Organism-specific databases

    SGDi S000002233. RPL31A.

    Phylogenomic databases

    GeneTreei ENSGT00390000005200.
    HOGENOMi HOG000216660.
    KOi K02910.
    OMAi WRKEVIT.
    OrthoDBi EOG7X0VW7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29486-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0C2H8.
    NextBioi 968804.

    Gene expression databases

    Genevestigatori P0C2H8.

    Family and domain databases

    Gene3Di 3.10.440.10. 1 hit.
    InterProi IPR000054. Ribosomal_L31e.
    IPR020052. Ribosomal_L31e_CS.
    IPR023621. Ribosomal_L31e_dom.
    [Graphical view ]
    PANTHERi PTHR10956. PTHR10956. 1 hit.
    Pfami PF01198. Ribosomal_L31e. 1 hit.
    [Graphical view ]
    ProDomi PD006030. Ribosomal_L31e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54575. SSF54575. 1 hit.
    PROSITEi PS01144. RIBOSOMAL_L31E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of a gene encoding yeast ribosomal protein L34."
      Schaap P.J., Molenaar C.M.T., Mager W.H., Planta R.J.
      Curr. Genet. 9:47-52(1984)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Carlsbergensis.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE OF 2-51, CLEAVAGE OF INITIATOR METHIONINE.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    6. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 6-83, ELECTRON MICROSCOPY.
    7. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    8. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    9. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    10. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL31A_YEAST
    AccessioniPrimary (citable) accession number: P0C2H8
    Secondary accession number(s): D6VRS4, P04649, Q3E7B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 2 genes for L31 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3