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Protein

60S ribosomal protein L27-B

Gene

RPL27B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 22900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL27 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29998-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27-B1 Publication
Alternative name(s):
Large ribosomal subunit protein eL27-B1 Publication
Gene namesi
Name:RPL27B1 Publication
Synonyms:RPL27
Ordered Locus Names:YDR471W
ORF Names:D8035.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR471W
SGDiS000002879 RPL27B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002789671 – 13660S ribosomal protein L27-BAdd BLAST136

Proteomic databases

MaxQBiP0C2H7
PaxDbiP0C2H7
PRIDEiP0C2H7
TopDownProteomicsiP0C2H7

PTM databases

CarbonylDBiP0C2H7
iPTMnetiP0C2H7

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi32524, 169 interactors
IntActiP0C2H7, 3 interactors
MINTiP0C2H7
STRINGi4932.YDR471W

Structurei

3D structure databases

ProteinModelPortaliP0C2H7
SMRiP0C2H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010721
HOGENOMiHOG000210138
InParanoidiP0C2H7
KOiK02901
OMAiSINMNHV
OrthoDBiEOG092C5ISN

Family and domain databases

Gene3Di2.30.30.770, 1 hit
InterProiView protein in InterPro
IPR038655 L27e_sf
IPR001141 Ribosomal_L27e
IPR018262 Ribosomal_L27e_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10497 PTHR10497, 1 hit
PfamiView protein in Pfam
PF01777 Ribosomal_L27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009396 Ribosomal_L27e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01107 RIBOSOMAL_L27E, 1 hit

Sequencei

Sequence statusi: Complete.

P0C2H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFLKAGKV AVVVRGRYAG KKVVIVKPHD EGSKSHPFGH ALVAGIERYP
60 70 80 90 100
SKVTKKHGAK KVAKRTKIKP FIKVVNYNHL LPTRYTLDVE AFKSVVSTET
110 120 130
FEQPSQREEA KKVVKKAFEE RHQAGKNQWF FSKLRF
Length:136
Mass (Da):15,505
Last modified:March 6, 2007 - v1
Checksum:i427D55EC9AB4A2E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64935.1
BK006938 Genomic DNA Translation: DAA12305.1
PIRiS69638
RefSeqiNP_010759.1, NM_001180779.1

Genome annotation databases

EnsemblFungiiYDR471W; YDR471W; YDR471W
GeneIDi852082
KEGGisce:YDR471W

Similar proteinsi

Entry informationi

Entry nameiRL27B_YEAST
AccessioniPrimary (citable) accession number: P0C2H7
Secondary accession number(s): D6VT95, P38706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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