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P0C2H6

- RL27A_YEAST

UniProt

P0C2H6 - RL27A_YEAST

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Protein
60S ribosomal protein L27-A
Gene
RPL27A, RPL27, YHR010W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD
Complete GO annotation...

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31073-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27-A
Gene namesi
Name:RPL27A
Synonyms:RPL27
Ordered Locus Names:YHR010W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

SGDiS000001052. RPL27A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 13613560S ribosomal protein L27-A
PRO_0000126092Add
BLAST

Proteomic databases

MaxQBiP0C2H6.

Expressioni

Gene expression databases

GenevestigatoriP0C2H6.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi36437. 92 interactions.
IntActiP0C2H6. 4 interactions.
MINTiMINT-8285600.
STRINGi4932.YHR010W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10a1-136[»]
1VWUelectron microscopy6.10a1-136[»]
3IZSelectron microscopy-a1-136[»]
3J65electron microscopy8.70Y1-136[»]
3U5EX-ray3.00Z1-136[»]
3U5IX-ray3.00Z1-136[»]
4B6Aelectron microscopy8.10Z1-136[»]
4BYNelectron microscopy4.30Z2-136[»]
4BYUelectron microscopy6.60Z2-136[»]
4CUWelectron microscopy3.70Z1-136[»]
ProteinModelPortaliP0C2H6.
SMRiP0C2H6. Positions 2-136.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010721.
HOGENOMiHOG000210138.
KOiK02901.
OMAiKIYKPGK.
OrthoDBiEOG7GXPR2.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10497. PTHR10497. 1 hit.
PfamiPF01777. Ribosomal_L27e. 1 hit.
[Graphical view]
ProDomiPD009396. Ribosomal_L27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01107. RIBOSOMAL_L27E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2H6-1 [UniParc]FASTAAdd to Basket

« Hide

MAKFLKAGKV AVVVRGRYAG KKVVIVKPHD EGSKSHPFGH ALVAGIERYP    50
LKVTKKHGAK KVAKRTKIKP FIKVVNYNHL LPTRYTLDVE AFKSVVSTET 100
FEQPSQREEA KKVVKKAFEE RHQAGKNQWF FSKLRF 136
Length:136
Mass (Da):15,531
Last modified:March 6, 2007 - v1
Checksum:iF3924B039AA2D85D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10400 Genomic DNA. Translation: AAB68944.1.
BK006934 Genomic DNA. Translation: DAA06699.1.
PIRiS46790.
RefSeqiNP_011874.1. NM_001179140.1.

Genome annotation databases

EnsemblFungiiYHR010W; YHR010W; YHR010W.
GeneIDi856401.
KEGGisce:YHR010W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10400 Genomic DNA. Translation: AAB68944.1 .
BK006934 Genomic DNA. Translation: DAA06699.1 .
PIRi S46790.
RefSeqi NP_011874.1. NM_001179140.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW8 electron microscopy 6.10 a 1-136 [» ]
1VWU electron microscopy 6.10 a 1-136 [» ]
3IZS electron microscopy - a 1-136 [» ]
3J65 electron microscopy 8.70 Y 1-136 [» ]
3U5E X-ray 3.00 Z 1-136 [» ]
3U5I X-ray 3.00 Z 1-136 [» ]
4B6A electron microscopy 8.10 Z 1-136 [» ]
4BYN electron microscopy 4.30 Z 2-136 [» ]
4BYU electron microscopy 6.60 Z 2-136 [» ]
4CUW electron microscopy 3.70 Z 1-136 [» ]
ProteinModelPortali P0C2H6.
SMRi P0C2H6. Positions 2-136.
ModBasei Search...

Protein-protein interaction databases

BioGridi 36437. 92 interactions.
IntActi P0C2H6. 4 interactions.
MINTi MINT-8285600.
STRINGi 4932.YHR010W.

Proteomic databases

MaxQBi P0C2H6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR010W ; YHR010W ; YHR010W .
GeneIDi 856401.
KEGGi sce:YHR010W.

Organism-specific databases

SGDi S000001052. RPL27A.

Phylogenomic databases

GeneTreei ENSGT00390000010721.
HOGENOMi HOG000210138.
KOi K02901.
OMAi KIYKPGK.
OrthoDBi EOG7GXPR2.

Enzyme and pathway databases

BioCyci YEAST:G3O-31073-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

NextBioi 981934.

Gene expression databases

Genevestigatori P0C2H6.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
InterProi IPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR10497. PTHR10497. 1 hit.
Pfami PF01777. Ribosomal_L27e. 1 hit.
[Graphical view ]
ProDomi PD009396. Ribosomal_L27e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50104. SSF50104. 1 hit.
PROSITEi PS01107. RIBOSOMAL_L27E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  4. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL27A_YEAST
AccessioniPrimary (citable) accession number: P0C2H6
Secondary accession number(s): D3DKV5, P38706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7380 molecules/cell in log phase SD medium.
There are 2 genes for L27 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi