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P0C2H6

- RL27A_YEAST

UniProt

P0C2H6 - RL27A_YEAST

Protein

60S ribosomal protein L27-A

Gene

RPL27A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31073-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L27-A
    Gene namesi
    Name:RPL27A
    Synonyms:RPL27
    Ordered Locus Names:YHR010W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    SGDiS000001052. RPL27A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 13613560S ribosomal protein L27-APRO_0000126092Add
    BLAST

    Proteomic databases

    MaxQBiP0C2H6.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C2H6.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi36437. 92 interactions.
    IntActiP0C2H6. 4 interactions.
    MINTiMINT-8285600.
    STRINGi4932.YHR010W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10a1-136[»]
    1VWUelectron microscopy6.10a1-136[»]
    3IZSelectron microscopy-a1-136[»]
    3J65electron microscopy8.70Y1-136[»]
    3U5EX-ray3.00Z1-136[»]
    3U5IX-ray3.00Z1-136[»]
    4B6Aelectron microscopy8.10Z1-136[»]
    4BYNelectron microscopy4.30Z2-136[»]
    4BYUelectron microscopy6.60Z2-136[»]
    4CUWelectron microscopy3.70Z1-136[»]
    ProteinModelPortaliP0C2H6.
    SMRiP0C2H6. Positions 2-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L27e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000010721.
    HOGENOMiHOG000210138.
    KOiK02901.
    OMAiKIYKPGK.
    OrthoDBiEOG7GXPR2.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR014722. Rib_L2_dom2.
    IPR001141. Ribosomal_L27e.
    IPR018262. Ribosomal_L27e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR10497. PTHR10497. 1 hit.
    PfamiPF01777. Ribosomal_L27e. 1 hit.
    [Graphical view]
    ProDomiPD009396. Ribosomal_L27e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01107. RIBOSOMAL_L27E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C2H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKFLKAGKV AVVVRGRYAG KKVVIVKPHD EGSKSHPFGH ALVAGIERYP    50
    LKVTKKHGAK KVAKRTKIKP FIKVVNYNHL LPTRYTLDVE AFKSVVSTET 100
    FEQPSQREEA KKVVKKAFEE RHQAGKNQWF FSKLRF 136
    Length:136
    Mass (Da):15,531
    Last modified:March 6, 2007 - v1
    Checksum:iF3924B039AA2D85D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10400 Genomic DNA. Translation: AAB68944.1.
    BK006934 Genomic DNA. Translation: DAA06699.1.
    PIRiS46790.
    RefSeqiNP_011874.1. NM_001179140.1.

    Genome annotation databases

    EnsemblFungiiYHR010W; YHR010W; YHR010W.
    GeneIDi856401.
    KEGGisce:YHR010W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10400 Genomic DNA. Translation: AAB68944.1 .
    BK006934 Genomic DNA. Translation: DAA06699.1 .
    PIRi S46790.
    RefSeqi NP_011874.1. NM_001179140.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 a 1-136 [» ]
    1VWU electron microscopy 6.10 a 1-136 [» ]
    3IZS electron microscopy - a 1-136 [» ]
    3J65 electron microscopy 8.70 Y 1-136 [» ]
    3U5E X-ray 3.00 Z 1-136 [» ]
    3U5I X-ray 3.00 Z 1-136 [» ]
    4B6A electron microscopy 8.10 Z 1-136 [» ]
    4BYN electron microscopy 4.30 Z 2-136 [» ]
    4BYU electron microscopy 6.60 Z 2-136 [» ]
    4CUW electron microscopy 3.70 Z 1-136 [» ]
    ProteinModelPortali P0C2H6.
    SMRi P0C2H6. Positions 2-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36437. 92 interactions.
    IntActi P0C2H6. 4 interactions.
    MINTi MINT-8285600.
    STRINGi 4932.YHR010W.

    Proteomic databases

    MaxQBi P0C2H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR010W ; YHR010W ; YHR010W .
    GeneIDi 856401.
    KEGGi sce:YHR010W.

    Organism-specific databases

    SGDi S000001052. RPL27A.

    Phylogenomic databases

    GeneTreei ENSGT00390000010721.
    HOGENOMi HOG000210138.
    KOi K02901.
    OMAi KIYKPGK.
    OrthoDBi EOG7GXPR2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31073-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 981934.

    Gene expression databases

    Genevestigatori P0C2H6.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR014722. Rib_L2_dom2.
    IPR001141. Ribosomal_L27e.
    IPR018262. Ribosomal_L27e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR10497. PTHR10497. 1 hit.
    Pfami PF01777. Ribosomal_L27e. 1 hit.
    [Graphical view ]
    ProDomi PD009396. Ribosomal_L27e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01107. RIBOSOMAL_L27E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    4. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL27A_YEAST
    AccessioniPrimary (citable) accession number: P0C2H6
    Secondary accession number(s): D3DKV5, P38706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7380 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L27 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3