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Protein

Heteroscorpine-1

Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity against B.subtilis, K.pneumoniae and P.aeruginosa.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Heteroscorpine-1
Short name:
HS-1
OrganismiHeterometrus laoticus (Thai giant scorpion)
Taxonomic identifieri217256 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

PD50 is 80 ul to crickets (Gryllus sp).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000027468020 – 95Heteroscorpine-1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 82By similarity
Disulfide bondi68 ↔ 87By similarity
Disulfide bondi72 ↔ 89By similarity

Post-translational modificationi

Contains 3 disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0C2F4

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP0C2F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR029237 Long_scorpion_toxin
PfamiView protein in Pfam
PF14866 Toxin_38, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK
60 70 80 90
LAKGEFQCVA NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY
Length:95
Mass (Da):10,246
Last modified:February 6, 2007 - v1
Checksum:i21CCE2CD82EFFFA6
GO

Mass spectrometryi

Molecular mass is 8293 Da from positions 20 - 95. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiKBX3_HETLA
AccessioniPrimary (citable) accession number: P0C2F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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