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P0C2F4 (KBX3_HETLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heteroscorpine-1

Short name=HS-1
OrganismHeterometrus laoticus (Thai giant scorpion)
Taxonomic identifier217256 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has antibacterial activity against B.subtilis, K.pneumoniae and P.aeruginosa.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Post-translational modification

Contains 3 disulfide bonds.

Toxic dose

PD50 is 80 ul to crickets (Gryllus sp). Ref.1

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 3 subfamily.

Mass spectrometry

Molecular mass is 8293 Da from positions 20 - 95. Determined by MALDI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 9576Heteroscorpine-1
PRO_0000274680

Amino acid modifications

Disulfide bond58 ↔ 82 By similarity
Disulfide bond68 ↔ 87 By similarity
Disulfide bond72 ↔ 89 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C2F4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 21CCE2CD82EFFFA6

FASTA9510,246
        10         20         30         40         50         60 
MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK LAKGEFQCVA 

        70         80         90 
NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY 

« Hide

References

[1]"Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom."
Uawonggul N., Thammasirirak S., Chaveerach A., Arkaravichien T., Bunyatratchata W., Ruangjirachuporn W., Jearranaiprepame P., Nakamura T., Matsuda M., Kobayashi M., Hattori S., Daduang S.
Toxicon 49:19-29(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20; 58-71 AND 80-86, MASS SPECTROMETRY, PARALYTIC DOSE.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKBX3_HETLA
AccessionPrimary (citable) accession number: P0C2F4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 3, 2012
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries