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Protein

Heteroscorpine-1

Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antibacterial activity against B.subtilis, K.pneumoniae and P.aeruginosa.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Heteroscorpine-1
Short name:
HS-1
OrganismiHeterometrus laoticus (Thai giant scorpion)
Taxonomic identifieri217256 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

PD50 is 80 ul to crickets (Gryllus sp).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000027468020 – 95Heteroscorpine-1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 82By similarity
Disulfide bondi68 ↔ 87By similarity
Disulfide bondi72 ↔ 89By similarity

Post-translational modificationi

Contains 3 disulfide bonds.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP0C2F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF14866. Toxin_38. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK
60 70 80 90
LAKGEFQCVA NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY
Length:95
Mass (Da):10,246
Last modified:February 6, 2007 - v1
Checksum:i21CCE2CD82EFFFA6
GO

Mass spectrometryi

Molecular mass is 8293 Da from positions 20 - 95. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKBX3_HETLA
AccessioniPrimary (citable) accession number: P0C2F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 12, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families