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P0C2F4

- KBX3_HETLA

UniProt

P0C2F4 - KBX3_HETLA

Protein

Heteroscorpine-1

Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has antibacterial activity against B.subtilis, K.pneumoniae and P.aeruginosa.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heteroscorpine-1
    Short name:
    HS-1
    OrganismiHeterometrus laoticus (Thai giant scorpion)
    Taxonomic identifieri217256 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    PD50 is 80 ul to crickets (Gryllus sp).1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 9576Heteroscorpine-1PRO_0000274680Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 82By similarity
    Disulfide bondi68 ↔ 87By similarity
    Disulfide bondi72 ↔ 89By similarity

    Post-translational modificationi

    Contains 3 disulfide bonds.

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C2F4-1 [UniParc]FASTAAdd to Basket

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    MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK   50
    LAKGEFQCVA NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY 95
    Length:95
    Mass (Da):10,246
    Last modified:February 6, 2007 - v1
    Checksum:i21CCE2CD82EFFFA6
    GO

    Mass spectrometryi

    Molecular mass is 8293 Da from positions 20 - 95. Determined by MALDI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom."
      Uawonggul N., Thammasirirak S., Chaveerach A., Arkaravichien T., Bunyatratchata W., Ruangjirachuporn W., Jearranaiprepame P., Nakamura T., Matsuda M., Kobayashi M., Hattori S., Daduang S.
      Toxicon 49:19-29(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20; 58-71 AND 80-86, MASS SPECTROMETRY, PARALYTIC DOSE.
      Tissue: Venom.

    Entry informationi

    Entry nameiKBX3_HETLA
    AccessioniPrimary (citable) accession number: P0C2F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3