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P0C2F4

- KBX3_HETLA

UniProt

P0C2F4 - KBX3_HETLA

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Protein

Heteroscorpine-1

Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has antibacterial activity against B.subtilis, K.pneumoniae and P.aeruginosa.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Heteroscorpine-1
Short name:
HS-1
OrganismiHeterometrus laoticus (Thai giant scorpion)
Taxonomic identifieri217256 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

PD50 is 80 ul to crickets (Gryllus sp).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 9576Heteroscorpine-1PRO_0000274680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 82 By similarity
Disulfide bondi68 ↔ 87 By similarity
Disulfide bondi72 ↔ 89 By similarity

Post-translational modificationi

Contains 3 disulfide bonds.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2F4-1 [UniParc]FASTAAdd to Basket

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MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK   50
LAKGEFQCVA NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY 95
Length:95
Mass (Da):10,246
Last modified:February 6, 2007 - v1
Checksum:i21CCE2CD82EFFFA6
GO

Mass spectrometryi

Molecular mass is 8293 Da from positions 20 - 95. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom."
    Uawonggul N., Thammasirirak S., Chaveerach A., Arkaravichien T., Bunyatratchata W., Ruangjirachuporn W., Jearranaiprepame P., Nakamura T., Matsuda M., Kobayashi M., Hattori S., Daduang S.
    Toxicon 49:19-29(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20; 58-71 AND 80-86, MASS SPECTROMETRY, PARALYTIC DOSE.
    Tissue: Venom.

Entry informationi

Entry nameiKBX3_HETLA
AccessioniPrimary (citable) accession number: P0C2F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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