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P0C2F3 (KBX1_TITST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin Tst-beta-KTx

Short name=TstbetaKTx
OrganismTityus stigmurus (Brazilian scorpion)
Taxonomic identifier50344 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3. Ref.3

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

This toxin does not inhibit Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Shaker IR and Kv11.1/KCNH2 potassium channels. Does not show cytolytic activity (Ref.3).

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Mass spectrometry

Molecular mass is 6716.8 Da from positions 1 - 60. Determined by ESI. Ref.1 Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Potassium channel toxin Tst-beta-KTx
PRO_0000274675

Amino acid modifications

Disulfide bond29 ↔ 50 By similarity
Disulfide bond36 ↔ 55 By similarity
Disulfide bond40 ↔ 57 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C2F3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BA0F39860AB5CD21

FASTA606,723
        10         20         30         40         50         60 
KLVALIPNDQ LRSILKAVVH KVAKTQFGCP AYEGYCNDHC NDIERKDGEC HGFKCKCAKD 

« Hide

References

[1]"Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species."
Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D.
Comp. Biochem. Physiol. 146C:147-157(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
Tissue: Venom.
[2]"Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
Tissue: Venom.
[3]"Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms."
Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F., Rodriguez de la Vega R.C., Tytgat J., Possani L.D.
Cell. Mol. Life Sci. 65:187-200(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKBX1_TITST
AccessionPrimary (citable) accession number: P0C2F3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries