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Protein

Potassium channel toxin Tst-beta-KTx

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3.1 Publication

Miscellaneous

This toxin does not inhibit Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Shaker IR and Kv11.1/KCNH2 potassium channels. Does not show cytolytic activity (PubMed:18030427).1 Publication

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin Tst-beta-KTx
Short name:
TstbetaKTx
OrganismiTityus stigmurus (Brazilian scorpion)
Taxonomic identifieri50344 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746751 – 60Potassium channel toxin Tst-beta-KTxAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 50By similarity
Disulfide bondi36 ↔ 55By similarity
Disulfide bondi40 ↔ 57By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP0C2F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF14866. Toxin_38. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C2F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KLVALIPNDQ LRSILKAVVH KVAKTQFGCP AYEGYCNDHC NDIERKDGEC
60
HGFKCKCAKD
Length:60
Mass (Da):6,723
Last modified:February 6, 2007 - v1
Checksum:iBA0F39860AB5CD21
GO

Mass spectrometryi

Molecular mass is 6716.8 Da from positions 1 - 60. Determined by ESI. 2 Publications

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKBX1_TITST
AccessioniPrimary (citable) accession number: P0C2F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 10, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families