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Protein

Potassium channel toxin Tst-beta-KTx

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Blocks potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin Tst-beta-KTx
Short name:
TstbetaKTx
OrganismiTityus stigmurus (Brazilian scorpion)
Taxonomic identifieri50344 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Potassium channel toxin Tst-beta-KTxPRO_0000274675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 50By similarity
Disulfide bondi36 ↔ 55By similarity
Disulfide bondi40 ↔ 57By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C2F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KLVALIPNDQ LRSILKAVVH KVAKTQFGCP AYEGYCNDHC NDIERKDGEC
60
HGFKCKCAKD
Length:60
Mass (Da):6,723
Last modified:February 6, 2007 - v1
Checksum:iBA0F39860AB5CD21
GO

Mass spectrometryi

Molecular mass is 6716.8 Da from positions 1 - 60. Determined by ESI. 2 Publications

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species."
    Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D.
    Comp. Biochem. Physiol. 146C:147-157(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
    Tissue: Venom.
  2. "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
    Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
    Peptides 28:31-37(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
    Tissue: Venom.
  3. "Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms."
    Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F., Rodriguez de la Vega R.C., Tytgat J., Possani L.D.
    Cell. Mol. Life Sci. 65:187-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKBX1_TITST
AccessioniPrimary (citable) accession number: P0C2F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not inhibit Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Shaker IR and Kv11.1/KCNH2 potassium channels. Does not show cytolytic activity (PubMed:18030427).1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.