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P0C2F3

- KBX1_TITST

UniProt

P0C2F3 - KBX1_TITST

Protein

Potassium channel toxin Tst-beta-KTx

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks potassium channels Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin Tst-beta-KTx
    Short name:
    TstbetaKTx
    OrganismiTityus stigmurus (Brazilian scorpion)
    Taxonomic identifieri50344 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Potassium channel toxin Tst-beta-KTxPRO_0000274675Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 50By similarity
    Disulfide bondi36 ↔ 55By similarity
    Disulfide bondi40 ↔ 57By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C2F3-1 [UniParc]FASTAAdd to Basket

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    KLVALIPNDQ LRSILKAVVH KVAKTQFGCP AYEGYCNDHC NDIERKDGEC   50
    HGFKCKCAKD 60
    Length:60
    Mass (Da):6,723
    Last modified:February 6, 2007 - v1
    Checksum:iBA0F39860AB5CD21
    GO

    Mass spectrometryi

    Molecular mass is 6716.8 Da from positions 1 - 60. Determined by ESI. 2 Publications

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species."
      Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D.
      Comp. Biochem. Physiol. 146C:147-157(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
      Tissue: Venom.
    2. "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
      Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
      Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
      Tissue: Venom.
    3. "Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms."
      Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F., Rodriguez de la Vega R.C., Tytgat J., Possani L.D.
      Cell. Mol. Life Sci. 65:187-200(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiKBX1_TITST
    AccessioniPrimary (citable) accession number: P0C2F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    This toxin does not inhibit Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Shaker IR and Kv11.1/KCNH2 potassium channels. Does not show cytolytic activity (PubMed:18030427).1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3