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P0C2E4 (OTCC_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:CPE0169
OrganismClostridium perfringens [Complete proteome] [HAMAP]
Taxonomic identifier1502 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000112911

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region271 – 2744Ornithine binding By similarity

Sites

Binding site1061Carbamoyl phosphate By similarity
Binding site1331Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1461Important for structural integrity By similarity

Experimental info

Sequence conflict1541E → A in CAA66365. Ref.1
Sequence conflict1621D → H in CAA66365. Ref.1
Sequence conflict287 – 2904MMDR → RWID in CAA66365. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P0C2E4 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 1AAC566B48DB4180

FASTA33137,153
        10         20         30         40         50         60 
MAVNLKGRSF LTLKDFTPAE IRYLLDLSHD LKAKKRAGIL GDSLKGKNVV LLFEKTSTRT 

        70         80         90        100        110        120 
RCAFECGAAE EGAHVTFLTN SQMGKKESIE DTAKVLGRMY DGIEFRGFKQ STVEELAKHA 

       130        140        150        160        170        180 
GVPVWNGLTD ADHPTQILAD FLTIEEHAHK PLSEIKLVFT GDTRNNMSYA LMYGAAKMGM 

       190        200        210        220        230        240 
HFVALGPDSL KPDEDILKEM QEYSKETGAT IEFSSNVDEA VKGADVIYTD IWVSMGEDES 

       250        260        270        280        290        300 
LYPERVKLLT PYKVTREMMN KTGNKNTLFM HCLPSFHDED TEVCKDMMDR LGLDIREVED 

       310        320        330 
EVFRSKNSVV FDEAENRMHT IKAVMVATAG R

« Hide

References

« Hide 'large scale' references
[1]"Collagenase gene (colA) is located in the 3'-flanking region of the perfringolysin O (pfoA) locus in Clostridium perfringens."
Ohtani K., Bando M., Swe T., Banu S., Oe M., Hayashi H., Shimizu T.
FEMS Microbiol. Lett. 146:155-159(1997) [PubMed: 9053381] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 13 / Type A.
[2]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X97768 Genomic DNA. Translation: CAA66365.1.
BA000016 Genomic DNA. Translation: BAB79875.1.
RefSeqNP_561085.1. NC_003366.1.

3D structure databases

ProteinModelPortalP0C2E4.
SMRP0C2E4. Positions 1-328.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID988410.
GenomeReviewsGene locus CPE0169 in contig BA000016_GR.
KEGGcpe:CPE0169.
NMPDRfig|195102.1.peg.232.
PATRIC19494218. VBICloPer59675_0226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMAMTPYQIN.
PhylomeDBP0C2E4.
ProtClustDBPRK04284.

Enzyme and pathway databases

BioCycCPER195102:CPE0169-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_CLOPE
AccessionPrimary (citable) accession number: P0C2E4
Secondary accession number(s): Q46169, Q46255
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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