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Protein

Cardiolipin synthase

Gene

cls

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212UniRule annotation1
Active sitei214UniRule annotation1
Active sitei219UniRule annotation1
Active sitei394UniRule annotation1
Active sitei396UniRule annotation1
Active sitei401UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthaseUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:cls
Synonyms:clsD
Ordered Locus Names:CPE1430
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012521 – 476Cardiolipin synthaseAdd BLAST476

Structurei

3D structure databases

ProteinModelPortaliP0C2E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 234PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini389 – 416PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiICSVGTA.
OrthoDBiPOG091H04OR.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls. 1 hit.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C2E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLFINMIFL INIVFIISII FIERRNPQTT WAWILILTFL PILGFIIYIL
60 70 80 90 100
FGQNITREKN FKRKILDDKT KQKYLNSFKS HYKLDNISLK YKDLIMMNFN
110 120 130 140 150
NDNSTYTQRN DIDLYFDANS LFEEMIDEIN KAEKFIHMEF YIFKSDEIGK
160 170 180 190 200
KILQALTKKA KEGVEVKLLV DSIGNSIHKK DIDKLKAAGG DFKIFFPGFC
210 220 230 240 250
KYINLRINYR NHRKILIIDS KVAFLGGFNI GDEYLGKDKN IGHWRDTHTK
260 270 280 290 300
IKGLAINDLE GRFLLDWSYA NESDLDIDLK KYFINPHSTD LPKKIIGAQI
310 320 330 340 350
VSSGPDHTEQ QIKNGYFKII NSAKKNLFIQ TPYFVPDEPM LEALRLAALS
360 370 380 390 400
GVDVKIMLPG NPDHKFMGWI ANSYFESLLN AGAKIYLYEK GFLHAKTIVA
410 420 430 440 450
DSSICSVGTA NMDIRSFSLN FESNIFIYNE AISKSMEEQF FKDLKVCTKV
460 470
TLESFEKRSI ISRIGESITR LVSPLM
Length:476
Mass (Da):55,040
Last modified:January 23, 2007 - v1
Checksum:i8EC32FC113F0A9CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81136.1.
RefSeqiWP_011010441.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB81136; BAB81136; BAB81136.
KEGGicpe:CPE1430.
PATRICi19496809. VBICloPer59675_1500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81136.1.
RefSeqiWP_011010441.1. NC_003366.1.

3D structure databases

ProteinModelPortaliP0C2E2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB81136; BAB81136; BAB81136.
KEGGicpe:CPE1430.
PATRICi19496809. VBICloPer59675_1500.

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiICSVGTA.
OrthoDBiPOG091H04OR.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls. 1 hit.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLS_CLOPE
AccessioniPrimary (citable) accession number: P0C2E2
Secondary accession number(s): Q9ZNC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.