ID   OXLA_TRIMU              Reviewed;          24 AA.
AC   P0C2D6;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-JUN-2009, entry version 12.
DE   RecName: Full=L-amino-acid oxidase;
DE            Short=LAAO;
DE            Short=LAO;
DE            Short=TM-LAO;
DE            EC=1.4.3.2;
DE   Flags: Fragment;
OS   Trimeresurus mucrosquamatus (Taiwan habu) (Protobothrops
OS   mucrosquamatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea;
OC   Viperidae; Crotalinae; Protobothrops.
OX   NCBI_TaxID=103944;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
RC   TISSUE=Venom;
RX   PubMed=12621545;
RA   Wei J.F., Wei Q., Lu Q.M., Tai H., Jin Y., Wang W.Y., Xiong Y.L.;
RT   "Purification, characterization and biological activity of an L-amino
RT   acid oxidase from Trimeresurus mucrosquamatus venom.";
RL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:219-224(2003).
CC   -!- FUNCTION: Catalyzes an oxidative deamination of predominantly
CC       hydrophobic and aromatic L-amino acids. Has an ability to induce
CC       apoptosis, and hemorrhage (By similarity). Has an antibacterial
CC       activity against E.coli, S.aureus, and B.dysenteriae. Has
CC       cytotoxic activity and induces platelet aggregation.
CC   -!- CATALYTIC ACTIVITY: An L-amino acid + H(2)O + O(2) = a 2-oxo acid
CC       + NH(3) + H(2)O(2).
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1
CC       subfamily.
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DR   HOVERGEN; P0C2D6; -.
DR   BRENDA; 1.4.3.2; 19091.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001716; F:L-amino-acid oxidase activity; IEA:EC.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Apoptosis; Blood coagulation;
KW   Direct protein sequencing; FAD; Flavoprotein; Glycoprotein;
KW   Oxidoreductase; Secreted; Toxin.
FT   CHAIN         1    >24       L-amino-acid oxidase.
FT                                /FTId=PRO_0000273571.
FT   NON_TER      24     24
SQ   SEQUENCE   24 AA;  2931 MW;  A1D8D75DE753FAA7 CRC64;
     ADNKNPLEEC FRETNYEEFL EIAR
//