Reviewed, UniProtKB/Swiss-Prot P0C2D6 (OXLA_TRIMU)

Names and origin

Protein names	Recommended name:     L-amino-acid oxidase       Short name=LAAO       Short name=LAO       Short name=TM-LAO     EC=1.4.3.2
Organism	Trimeresurus mucrosquamatus (Taiwan habu) (Protobothrops mucrosquamatus)
Taxonomic identifier	103944 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops

Protein attributes

Sequence length	24 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Has an ability to induce apoptosis, and hemorrhage By similarity. Has an antibacterial activity against E.coli, S.aureus, and B.dysenteriae. Has cytotoxic activity and induces platelet aggregation.
Catalytic activity	An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD By similarity.
Subunit structure	Homodimer. Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
Biological process	Apoptosis Blood coagulation
Cellular component	Secreted
Ligand	FAD Flavoprotein
Molecular function	Antibiotic Antimicrobial Oxidoreductase Toxin
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›24	›24	L-amino-acid oxidase		PRO_0000273571
Experimental info
	Non-terminal residue	24	1

Sequences

	Sequence		Length	Mass (Da)
	P0C2D6-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: A1D8D75DE753FAA7	FASTA	24	2,931
	10 20 ADNKNPLEEC FRETNYEEFL EIAR

References

[1]

"Purification, characterization and biological activity of an L-amino acid oxidase from Trimeresurus mucrosquamatus venom." Wei J.F., Wei Q., Lu Q.M., Tai H., Jin Y., Wang W.Y., Xiong Y.L. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:219-224(2003) [PubMed: 12621545] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P0C2D6.
Enzyme and pathway databases
BRENDA	1.4.3.2. 19091.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

OXLA_TRIMU

Accession

Primary (citable) accession number: P0C2D6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)