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P0C2D5 (OXLA_PROFL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-amino-acid oxidase

Short name=LAAO
Short name=LAO
EC=1.4.3.2
Alternative name(s):
Apoxin I-like protein
Okinawa Habu apoxin protein-1
Short name=OHAP-1
OrganismProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifier88087 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Protein attributes

Sequence length30 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. This protein has an ability to induce hemolysis and apoptosis. Ref.1 Ref.2

Catalytic activity

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2. Ref.1

Cofactor

FAD By similarity.

Subunit structure

Monomer. This is in contrast with most of its orthologs, that are non-covalently linked homodimers. Ref.2

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›30›30L-amino-acid oxidase
PRO_0000273570

Amino acid modifications

Disulfide bond10 ↔ ? By similarity

Experimental info

Sequence conflict21D → H AA sequence Ref.2
Sequence conflict101C → Y AA sequence Ref.2
Non-terminal residue301

Sequences

Sequence LengthMass (Da)Tools
P0C2D5 [UniParc].

Last modified September 21, 2011. Version 2.
Checksum: 37AE5DC946D491D0

FASTA303,603
        10         20         30 
ADDRNPLEEC FRETDYEEFL EIARNGLKKT 

« Hide

References

[1]"Apoptotic effect in the glioma cells induced by specific protein extracted from Okinawa Habu (Trimeresurus flavoviridis) venom in relation to oxidative stress."
Sun L.-K., Yoshii Y., Hyodo A., Tsurushima H., Saito A., Harakuni T., Li Y.-P., Kariya K., Nozaki M., Morine N.
Toxicol. in Vitro 17:169-177(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY.
Tissue: Venom.
[2]"Characterization of an apoptosis-inducing factor in Habu snake venom as a glycyrrhizin (GL)-binding protein potently inhibited by GL in vitro."
Abe Y., Shimoyama Y., Munakata H., Ito J., Nagata N., Ohtsuki K.
Biol. Pharm. Bull. 21:924-927(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-20, FUNCTION, SUBUNIT.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameOXLA_PROFL
AccessionPrimary (citable) accession number: P0C2D5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families