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Reviewed, UniProtKB/Swiss-Prot P0C2D4 (OXLA_NAJKA)

Last modified November 4, 2008. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    L-amino-acid oxidase
    EC=1.4.3.2
Alternative name(s):
    K-LAO
    LAAO
      Short name=LAO
OrganismNaja kaouthia (Monocled cobra) (Naja siamensis)
Taxonomic identifier8649 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataScleroglossaSerpentesColubroideaElapidaeElapinaeNaja

Protein attributes

Sequence length38 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Is very active against L-Phe and L-Tyr, moderately active against L-Trp, L-Met, L-Leu, and L-Arg. Inhibits both agonist- and shear stress-induced platelet aggregation (SIPA) dose-dependently through the formation of hydrogen peroxide (H(2)O(2)). May induce apoptosis and hemorrhage. May have an antibacterial activity.

Catalytic activity

An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).

Cofactor

FAD By similarity.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Biophysicochemical properties

pH dependence:

Optimum pH is 8.5, unlike many other venom L-amino acid oxidase, is also stable in alkaline medium.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›38›38L-amino-acid oxidase
PRO_0000273569

Experimental info

Non-terminal residue381

Sequences

Sequence LengthMass (Da)Tools
P0C2D4-1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: D988B9FC32DDDE08

FASTA384,514
        10         20         30 
DDRRSPLEEC FQQNDYEEFL EIAKNGLKKT XNPKHVXV 

« Hide

References

[1]"Inhibition of human platelet aggregation by L-amino acid oxidase purified from Naja naja kaouthia venom."
Sakurai Y., Takatsuka H., Yoshioka A., Matsui T., Suzuki M., Titani K., Fujimura Y.
Toxicon 39:1827-1833(2001) [PubMed: 11600144] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Purification and properties of the L-amino acid oxidase from monocellate cobra (Naja naja kaouthia) venom."
Tan N.-H., Swaminathan S.
Int. J. Biochem. 24:967-973(1992) [PubMed: 1612186] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP0C2D4.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameOXLA_NAJKA
AccessionPrimary (citable) accession number: P0C2D4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 4, 2008
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectTox-Prot (Toxin Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents