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Protein

39S ribosomal protein L22, mitochondrial

Gene

Mrpl22

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-5389840. Mitochondrial translation elongation.
R-RNO-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Gene namesi
Name:Mrpl22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309277. Mrpl22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Mitochondrion1 PublicationAdd
BLAST
Chaini41 – 20616639S ribosomal protein L22, mitochondrialPRO_0000273239Add
BLAST

Proteomic databases

PaxDbiP0C2C0.
PRIDEiP0C2C0.

Expressioni

Gene expression databases

GenevisibleiP0C2C0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029336.

Structurei

3D structure databases

ProteinModelPortaliP0C2C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1711. Eukaryota.
COG0091. LUCA.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiP0C2C0.
KOiK02890.
OMAiMWYIAAF.
OrthoDBiEOG79CZ0R.
PhylomeDBiP0C2C0.
TreeFamiTF315111.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALLRELG ALWVPNLRIW TTQMLRVLPQ SCIHTSTSLD ISRRWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAQI IKEVLLEAQD MAVRDHNVEF RSNLHIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPRP EAPRTAVDHA KEYIQQLRSR

TIIHTL
Length:206
Mass (Da):24,039
Last modified:January 23, 2007 - v1
Checksum:iD04C32FBADBF6D68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551P → D AA sequence (PubMed:9857009).Curated
Sequence conflicti58 – 581P → D AA sequence (PubMed:9857009).Curated
Sequence conflicti61 – 611P → D AA sequence (PubMed:9857009).Curated
Sequence conflicti64 – 641P → D AA sequence (PubMed:9857009).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03075027 Genomic DNA. No translation available.
RefSeqiNP_001099251.1. NM_001105781.1.
UniGeneiRn.13421.

Genome annotation databases

GeneIDi287302.
KEGGirno:287302.
UCSCiRGD:1309277. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03075027 Genomic DNA. No translation available.
RefSeqiNP_001099251.1. NM_001105781.1.
UniGeneiRn.13421.

3D structure databases

ProteinModelPortaliP0C2C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029336.

Proteomic databases

PaxDbiP0C2C0.
PRIDEiP0C2C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287302.
KEGGirno:287302.
UCSCiRGD:1309277. rat.

Organism-specific databases

CTDi29093.
RGDi1309277. Mrpl22.

Phylogenomic databases

eggNOGiKOG1711. Eukaryota.
COG0091. LUCA.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiP0C2C0.
KOiK02890.
OMAiMWYIAAF.
OrthoDBiEOG79CZ0R.
PhylomeDBiP0C2C0.
TreeFamiTF315111.

Enzyme and pathway databases

ReactomeiR-RNO-5389840. Mitochondrial translation elongation.
R-RNO-5419276. Mitochondrial translation termination.

Miscellaneous databases

NextBioi625813.
PROiP0C2C0.

Gene expression databases

GenevisibleiP0C2C0. RN.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences."
    Goldschmidt-Reisin S., Kitakawa M., Herfurth E., Wittmann-Liebold B., Grohmann L., Graack H.-R.
    J. Biol. Chem. 273:34828-34836(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-66.

Entry informationi

Entry nameiRM22_RAT
AccessioniPrimary (citable) accession number: P0C2C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.