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Protein

Thiol:disulfide interchange protein DsbA

Gene

dsbA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.8.4.2. 5087.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbA
Gene namesi
Name:dsbA
Ordered Locus Names:PA5489
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5489.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003426223 – 211Thiol:disulfide interchange protein DsbAAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C2B2.
PRIDEiP0C2B2.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5489.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni27 – 29Combined sources3
Beta strandi30 – 33Combined sources4
Beta strandi45 – 52Combined sources8
Helixi57 – 71Combined sources15
Beta strandi77 – 83Combined sources7
Helixi89 – 102Combined sources14
Helixi106 – 118Combined sources13
Helixi127 – 135Combined sources9
Turni136 – 138Combined sources3
Helixi141 – 148Combined sources8
Helixi151 – 167Combined sources17
Beta strandi171 – 177Combined sources7
Turni178 – 180Combined sources3
Beta strandi181 – 184Combined sources4
Helixi185 – 188Combined sources4
Helixi191 – 207Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MBTNMR-A23-211[»]
2MBUNMR-A23-211[»]
3H93X-ray1.50A23-211[»]
4ZL7X-ray1.92A22-211[»]
4ZL8X-ray1.40A22-211[»]
4ZL9X-ray1.70A22-211[»]
5DCHX-ray1.45A22-211[»]
ProteinModelPortaliP0C2B2.
SMRiP0C2B2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2B2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 203ThioredoxinPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the thioredoxin family. DsbA subfamily.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4108Z33. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000265318.
InParanoidiP0C2B2.
KOiK03673.
OMAiDKVSPLM.
PhylomeDBiP0C2B2.

Family and domain databases

CDDicd03019. DsbA_DsbA. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLILTAML AMASLFGMAA QADDYTAGKE YVELSSPVPV SQPGKIEVVE
60 70 80 90 100
LFWYGCPHCY AFEPTIVPWS EKLPADVHFV RLPALFGGIW NVHGQMFLTL
110 120 130 140 150
ESMGVEHDVH NAVFEAIHKE HKKLATPEEM ADFLAGKGVD KEKFLSTYNS
160 170 180 190 200
FAIKGQMEKA KKLAMAYQVT GVPTMVVNGK YRFDIGSAGG PEETLKLADY
210
LIEKERAAAK K
Length:211
Mass (Da):23,375
Last modified:January 9, 2007 - v1
Checksum:iA994F93CC8E8C9F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209Missing (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84726 Genomic DNA. Translation: AAB41795.1.
AE004091 Genomic DNA. Translation: AAG08874.1.
PIRiH82960.
RefSeqiNP_254176.1. NC_002516.2.
WP_003096976.1. NZ_ASJY01000840.1.

Genome annotation databases

EnsemblBacteriaiAAG08874; AAG08874; PA5489.
GeneIDi877731.
KEGGipae:PA5489.
PATRICi19845865. VBIPseAer58763_5754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84726 Genomic DNA. Translation: AAB41795.1.
AE004091 Genomic DNA. Translation: AAG08874.1.
PIRiH82960.
RefSeqiNP_254176.1. NC_002516.2.
WP_003096976.1. NZ_ASJY01000840.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MBTNMR-A23-211[»]
2MBUNMR-A23-211[»]
3H93X-ray1.50A23-211[»]
4ZL7X-ray1.92A22-211[»]
4ZL8X-ray1.40A22-211[»]
4ZL9X-ray1.70A22-211[»]
5DCHX-ray1.45A22-211[»]
ProteinModelPortaliP0C2B2.
SMRiP0C2B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5489.

Proteomic databases

PaxDbiP0C2B2.
PRIDEiP0C2B2.

Protocols and materials databases

DNASUi877731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08874; AAG08874; PA5489.
GeneIDi877731.
KEGGipae:PA5489.
PATRICi19845865. VBIPseAer58763_5754.

Organism-specific databases

PseudoCAPiPA5489.

Phylogenomic databases

eggNOGiENOG4108Z33. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000265318.
InParanoidiP0C2B2.
KOiK03673.
OMAiDKVSPLM.
PhylomeDBiP0C2B2.

Enzyme and pathway databases

BRENDAi1.8.4.2. 5087.

Miscellaneous databases

EvolutionaryTraceiP0C2B2.

Family and domain databases

CDDicd03019. DsbA_DsbA. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSBA_PSEAE
AccessioniPrimary (citable) accession number: P0C2B2
Secondary accession number(s): P95460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.