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Protein

Thiol:disulfide interchange protein DsbA

Gene

dsbA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5616-MONOMER
BRENDAi1.8.4.2 5087

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbA
Gene namesi
Name:dsbA
Ordered Locus Names:PA5489
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5489

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003426223 – 211Thiol:disulfide interchange protein DsbAAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C2B2

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5489

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni27 – 29Combined sources3
Beta strandi30 – 33Combined sources4
Beta strandi45 – 52Combined sources8
Helixi57 – 71Combined sources15
Beta strandi77 – 83Combined sources7
Helixi89 – 102Combined sources14
Helixi106 – 118Combined sources13
Helixi127 – 135Combined sources9
Turni136 – 138Combined sources3
Helixi141 – 148Combined sources8
Helixi151 – 167Combined sources17
Beta strandi171 – 177Combined sources7
Turni178 – 180Combined sources3
Beta strandi181 – 184Combined sources4
Helixi185 – 188Combined sources4
Helixi191 – 207Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MBTNMR-A23-211[»]
3H93X-ray1.50A23-211[»]
4ZL7X-ray1.92A22-211[»]
4ZL8X-ray1.40A22-211[»]
4ZL9X-ray1.70A22-211[»]
5DCHX-ray1.45A22-211[»]
5TLQNMR-A23-211[»]
ProteinModelPortaliP0C2B2
SMRiP0C2B2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2B2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 203ThioredoxinPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the thioredoxin family. DsbA subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4108Z33 Bacteria
COG0526 LUCA
HOGENOMiHOG000265318
InParanoidiP0C2B2
KOiK03673
OMAiEVVEFFW
PhylomeDBiP0C2B2

Family and domain databases

CDDicd03019 DsbA_DsbA, 1 hit
InterProiView protein in InterPro
IPR001853 DSBA-like_thioredoxin_dom
IPR023205 DsbA/DsbL
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF01323 DSBA, 1 hit
PIRSFiPIRSF001488 Tdi_protein, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLILTAML AMASLFGMAA QADDYTAGKE YVELSSPVPV SQPGKIEVVE
60 70 80 90 100
LFWYGCPHCY AFEPTIVPWS EKLPADVHFV RLPALFGGIW NVHGQMFLTL
110 120 130 140 150
ESMGVEHDVH NAVFEAIHKE HKKLATPEEM ADFLAGKGVD KEKFLSTYNS
160 170 180 190 200
FAIKGQMEKA KKLAMAYQVT GVPTMVVNGK YRFDIGSAGG PEETLKLADY
210
LIEKERAAAK K
Length:211
Mass (Da):23,375
Last modified:January 9, 2007 - v1
Checksum:iA994F93CC8E8C9F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209Missing (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84726 Genomic DNA Translation: AAB41795.1
AE004091 Genomic DNA Translation: AAG08874.1
PIRiH82960
RefSeqiNP_254176.1, NC_002516.2
WP_003096976.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG08874; AAG08874; PA5489
GeneIDi877731
KEGGipae:PA5489
PATRICifig|208964.12.peg.5754

Similar proteinsi

Entry informationi

Entry nameiDSBA_PSEAE
AccessioniPrimary (citable) accession number: P0C2B2
Secondary accession number(s): P95460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health