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Protein

Thiol:disulfide interchange protein DsbA

Gene

dsbA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.8.4.2. 5087.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbA
Gene namesi
Name:dsbA
Ordered Locus Names:PA5489
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5489.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 211189Thiol:disulfide interchange protein DsbAPRO_0000034262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C2B2.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5489.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni27 – 293Combined sources
Beta strandi30 – 334Combined sources
Beta strandi45 – 528Combined sources
Helixi57 – 7115Combined sources
Beta strandi77 – 837Combined sources
Helixi89 – 10214Combined sources
Helixi106 – 11813Combined sources
Helixi127 – 1359Combined sources
Turni136 – 1383Combined sources
Helixi141 – 1488Combined sources
Helixi151 – 16717Combined sources
Beta strandi171 – 1777Combined sources
Turni178 – 1803Combined sources
Beta strandi181 – 1844Combined sources
Helixi185 – 1884Combined sources
Helixi191 – 20717Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MBTNMR-A23-211[»]
2MBUNMR-A23-211[»]
3H93X-ray1.50A23-211[»]
4ZL7X-ray1.92A22-211[»]
4ZL8X-ray1.40A22-211[»]
4ZL9X-ray1.70A22-211[»]
ProteinModelPortaliP0C2B2.
SMRiP0C2B2. Positions 22-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C2B2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 203181ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family. DsbA subfamily.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4108Z33. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000265318.
InParanoidiP0C2B2.
KOiK03673.
OMAiDKVSPLM.
OrthoDBiEOG68Q0Q6.
PhylomeDBiP0C2B2.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C2B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLILTAML AMASLFGMAA QADDYTAGKE YVELSSPVPV SQPGKIEVVE
60 70 80 90 100
LFWYGCPHCY AFEPTIVPWS EKLPADVHFV RLPALFGGIW NVHGQMFLTL
110 120 130 140 150
ESMGVEHDVH NAVFEAIHKE HKKLATPEEM ADFLAGKGVD KEKFLSTYNS
160 170 180 190 200
FAIKGQMEKA KKLAMAYQVT GVPTMVVNGK YRFDIGSAGG PEETLKLADY
210
LIEKERAAAK K
Length:211
Mass (Da):23,375
Last modified:January 9, 2007 - v1
Checksum:iA994F93CC8E8C9F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091Missing (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84726 Genomic DNA. Translation: AAB41795.1.
AE004091 Genomic DNA. Translation: AAG08874.1.
PIRiH82960.
RefSeqiNP_254176.1. NC_002516.2.
WP_003096976.1. NZ_ASJY01000840.1.

Genome annotation databases

EnsemblBacteriaiAAG08874; AAG08874; PA5489.
GeneIDi877731.
KEGGipae:PA5489.
PATRICi19845865. VBIPseAer58763_5754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84726 Genomic DNA. Translation: AAB41795.1.
AE004091 Genomic DNA. Translation: AAG08874.1.
PIRiH82960.
RefSeqiNP_254176.1. NC_002516.2.
WP_003096976.1. NZ_ASJY01000840.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MBTNMR-A23-211[»]
2MBUNMR-A23-211[»]
3H93X-ray1.50A23-211[»]
4ZL7X-ray1.92A22-211[»]
4ZL8X-ray1.40A22-211[»]
4ZL9X-ray1.70A22-211[»]
ProteinModelPortaliP0C2B2.
SMRiP0C2B2. Positions 22-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5489.

Proteomic databases

PaxDbiP0C2B2.

Protocols and materials databases

DNASUi877731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08874; AAG08874; PA5489.
GeneIDi877731.
KEGGipae:PA5489.
PATRICi19845865. VBIPseAer58763_5754.

Organism-specific databases

PseudoCAPiPA5489.

Phylogenomic databases

eggNOGiENOG4108Z33. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000265318.
InParanoidiP0C2B2.
KOiK03673.
OMAiDKVSPLM.
OrthoDBiEOG68Q0Q6.
PhylomeDBiP0C2B2.

Enzyme and pathway databases

BRENDAi1.8.4.2. 5087.

Miscellaneous databases

EvolutionaryTraceiP0C2B2.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR023205. DsbA/DsbL.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF001488. Tdi_protein. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a dsbA-homologous gene from Pseudomonas aeruginosa."
    Leipelt M., Schneidinger B., Jaeger K.-E.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiDSBA_PSEAE
AccessioniPrimary (citable) accession number: P0C2B2
Secondary accession number(s): P95460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.