ATP-dependent Clp protease ATP-binding subunit ClpC - Staphylococcus aureus (strain COL)

Preferred order of sections

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC

Gene names

Name:	clpC
Ordered Locus Names:	SACOL0570

Organism

Staphylococcus aureus (strain COL) [Complete proteome] [HAMAP]

Taxonomic identifier

93062 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length	818 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP By similarity.

Sequence similarities

Belongs to the clpA/clpB family. ClpC subfamily.

Contains 1 UVR domain.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein metabolic process Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 818

818

ATP-dependent Clp protease ATP-binding subunit ClpC

PRO_0000269682

Regions

Domain

417 – 452

36

UVR

Nucleotide binding

208 – 215

8

ATP Potential

Nucleotide binding

545 – 552

8

ATP Potential

Region

163 – 410

248

I

Region

471 – 662

192

II

Sequences

Sequence

Length

Mass (Da)

Tools

P0C281 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 404DBB1643BAA31F
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FASTA

818

91,037

        10         20         30         40         50         60 
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL ESFNITEDKV 

        70         80         90        100        110        120 
IEEVEKLIGH GQDHVGTLHY TPRAKKVIEL SMDEARKLHH NFVGTEHILL GLIRENEGVA 

       130        140        150        160        170        180 
ARVFANLDLN ITKARAQVVK ALGNPEMSNK NAQASKSNNT PTLDSLARDL TVIAKDGTLD 

       190        200        210        220        230        240 
PVIGRDKEIT RVIEVLSRRT KNNPVLIGEP GVGKTAIAEG LAQAIVNNEV PETLKDKRVM 

       250        260        270        280        290        300 
SLDMGTVVAG TKYRGEFEER LKKVMEEIQQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL 

       310        320        330        340        350        360 
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPVQVD EPSVVDTVAI LKGLRDRYEA 

       370        380        390        400        410        420 
HHRINISDEA IEAAVKLSNR YVSDRFLPDK AIDLIDEASS KVRLKSHTTP NNLKEIEQEI 

       430        440        450        460        470        480 
EKVKNEKDAA VHAQEFENAA NLRDKQTKLE KQYEEAKNEW KNAQNGMSTS LSEEDIAEVI 

       490        500        510        520        530        540 
AGWTGIPLTK INETESEKLL SLEDTLHERV IGQKDAVNSI SKAVRRARAG LKDPKRPIGS 

       550        560        570        580        590        600 
FIFLGPTGVG KTELARALAE SMFGDDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG 

       610        620        630        640        650        660 
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR NTIIIMTSNV 

       670        680        690        700        710        720 
GAQELQDQRF AGFGGSSDGQ DYETIRKTML KELKNSFRPE FLNRVDDIIV FHKLTKEELK 

       730        740        750        760        770        780 
EIVTMMVNKL TNRLSEQNIN IIVTDKAKDK IAEEGYDPEY GARPLIRAIQ KTIEDNLSEL 

       790        800        810 
ILDGNQIEGK KVTVDHDGKE FKYDIAEQTS ETKTPSQA

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References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.

Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: COL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000046 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P0C281.
SMR	P0C281. Positions 2-801.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
CMR	Search...
Family and domain databases
Gene3D	1.10.1780.10. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR003959. ATPase_AAA_core. IPR018368. Chaperonin_ClpA/B_CS. IPR001270. Chaprnin_ClpA/B. IPR019489. Clp_ATPase_C. IPR004176. Clp_N. IPR023150. Dbl_Clp-N. IPR001943. UVR_dom. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF07724. AAA_2. 1 hit. PF02861. Clp_N. 2 hits. PF10431. ClpB_D2-small. 1 hit. PF02151. UVR. 1 hit. [Graphical view]
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 2 hits. SM01086. ClpB_D2-small. 1 hit. [Graphical view]
PROSITE	PS00870. CLPAB_1. 1 hit. PS00871. CLPAB_2. 1 hit. PS50151. UVR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPC_STAAC

Accession

Primary (citable) accession number: P0C281

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families