ID PELS1_YEAST Reviewed; 40 AA. AC P0C271; D6W182; Q8TGS3; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 12-DEC-2006, sequence version 1. DT 24-JAN-2024, entry version 67. DE RecName: Full=Peroxisomal LYS1 stabilizing protein 1 {ECO:0000303|PubMed:35563734}; GN Name=PLS1 {ECO:0000303|PubMed:35563734}; OrderedLocusNames=YNL097C-B; GN ORFNames=YNL097C-A; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=SK1; RX PubMed=16273108; DOI=10.1038/ng1674; RA Deutschbauer A.M., Davis R.W.; RT "Quantitative trait loci mapped to single-nucleotide resolution in yeast."; RL Nat. Genet. 37:1333-1340(2005). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 96604 / S288c / FY1679; RX PubMed=8701612; RX DOI=10.1002/(sici)1097-0061(19960330)12:4<403::aid-yea923>3.0.co;2-h; RA Saiz J.E., Buitrago M.J., Soler A., del Rey F., Revuelta J.L.; RT "The sequence of a 21.3 kb DNA fragment from the left arm of yeast RT chromosome XIV reveals LEU4, MET4, POL1, RAS2, and six new open reading RT frames."; RL Yeast 12:403-409(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169873; RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F., RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its RT evolutionary implications."; RL Nature 387:93-98(1997). RN [4] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11753363; DOI=10.1038/nbt0102-58; RA Kumar A., Harrison P.M., Cheung K.-H., Lan N., Echols N., Bertone P., RA Miller P., Gerstein M.B., Snyder M.; RT "An integrated approach for finding overlooked genes in yeast."; RL Nat. Biotechnol. 20:58-63(2002). RN [6] RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE. RX PubMed=35563734; DOI=10.3390/cells11091426; RA David Y., Castro I.G., Yifrach E., Bibi C., Katawi E., Yahav Har-Shai D., RA Brodsky S., Barkai N., Ravid T., Eisenstein M., Pietrokovski S., RA Schuldiner M., Zalckvar E.; RT "Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine RT Biosynthesis."; RL Cells 11:1426-1426(2022). CC -!- FUNCTION: Modulates the lysine biosynthesis pathway, possibly by CC stabilizing the lysine biosynthesis LYS1 protein in lysine-deplete CC conditions. {ECO:0000269|PubMed:35563734}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:35563734}. CC Peroxisome matrix {ECO:0000269|PubMed:35563734}. Note=Localizes to CC peroxisomes in lysine-deplete conditions in a LYS1- and PEX5-dependent CC manner. {ECO:0000269|PubMed:35563734}. CC -!- DISRUPTION PHENOTYPE: Decreases the level of LYS1 protein. CC {ECO:0000269|PubMed:35563734}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ115393; AAZ22510.1; -; Genomic_DNA. DR EMBL; Z50161; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z71373; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z71374; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF479912; AAL79225.1; -; Genomic_DNA. DR EMBL; BK006947; DAA10448.1; -; Genomic_DNA. DR RefSeq; NP_878155.1; NM_001184620.1. DR AlphaFoldDB; P0C271; -. DR BioGRID; 37055; 29. DR STRING; 4932.YNL097C-B; -. DR PaxDb; 4932-YNL097C-B; -. DR EnsemblFungi; YNL097C-B_mRNA; YNL097C-B; YNL097C-B. DR GeneID; 1466513; -. DR KEGG; sce:YNL097C-B; -. DR AGR; SGD:S000028699; -. DR SGD; S000028699; YNL097C-B. DR VEuPathDB; FungiDB:YNL097C-B; -. DR HOGENOM; CLU_3299646_0_0_1; -. DR InParanoid; P0C271; -. DR OrthoDB; 5492083at2759; -. DR BioCyc; YEAST:G3O-33411-MONOMER; -. DR BioGRID-ORCS; 1466513; 1 hit in 10 CRISPR screens. DR PRO; PR:P0C271; -. DR Proteomes; UP000002311; Chromosome XIV. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell. PE 4: Predicted; KW Cytoplasm; Peroxisome; Reference proteome. FT CHAIN 1..40 FT /note="Peroxisomal LYS1 stabilizing protein 1" FT /id="PRO_0000268630" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 40 AA; 4622 MW; 20051EEF0A14A4B3 CRC64; MTAKTKQSWN KGIWENGKQG SHQQTFLPKI WVNIYSTPTS //