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Protein

Uncharacterized serine/threonine-protein kinase SBK3

Gene

SBK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotation
Active sitei163 – 1631Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP0C264.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized serine/threonine-protein kinase SBK3 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 3
Sugen kinase 110
Gene namesi
Name:SBK3
Synonyms:SGK110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:44121. SBK3.

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5116.
GuidetoPHARMACOLOGYi2290.

Polymorphism and mutation databases

DMDMi161783904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Uncharacterized serine/threonine-protein kinase SBK3PRO_0000262995Add
BLAST

Proteomic databases

PaxDbiP0C264.
PRIDEiP0C264.

Expressioni

Gene expression databases

ExpressionAtlasiP0C264. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000388220.

Chemistry

BindingDBiP0C264.

Structurei

3D structure databases

ProteinModelPortaliP0C264.
SMRiP0C264. Positions 7-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 309267Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 27890Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiP0C264.
KOiK08858.
OMAiGRCVSAH.
PhylomeDBiP0C264.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRASETPE DGDPEEDTAT ALQRLVELTT SRVTPVRSLR DQYHLIRKLG
60 70 80 90 100
SGSYGRVLLA QPHQGGPAVA LKLLRRDLVL RSTFLREFCV GRCVSAHPGL
110 120 130 140 150
LQTLAGPLQT PRYFAFAQEY APCGDLSGML QERGLPELLV KRVVAQLAGA
160 170 180 190 200
LDFLHSRGLV HADVKPDNVL VFDPVCSRVA LGDLGLTRPE GSPTPAPPVP
210 220 230 240 250
LPTAPPELCL LLPPDTLPLR PAVDSWGLGV LLFCAATACF PWDVALAPNP
260 270 280 290 300
EFEAFAGWVT TKPQPPQPPP PWDQFAPPAL ALLQGLLDLD PETRSPPLAV
310 320 330 340 350
LDFLGDDWGL QGNREGPGVL GSAVSYEDRE EGGSSLEEWT DEGDDSKSGG

RTGTDGGAP
Length:359
Mass (Da):38,488
Last modified:October 23, 2007 - v2
Checksum:i3E6AFF74412256C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
CCDSiCCDS74457.1.
RefSeqiNP_001186753.1. NM_001199824.2.
UniGeneiHs.712129.

Genome annotation databases

EnsembliENST00000612221; ENSP00000483467; ENSG00000231274.
GeneIDi100130827.
KEGGihsa:100130827.
UCSCiuc032ifx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
CCDSiCCDS74457.1.
RefSeqiNP_001186753.1. NM_001199824.2.
UniGeneiHs.712129.

3D structure databases

ProteinModelPortaliP0C264.
SMRiP0C264. Positions 7-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000388220.

Chemistry

BindingDBiP0C264.
ChEMBLiCHEMBL5116.
GuidetoPHARMACOLOGYi2290.

Polymorphism and mutation databases

DMDMi161783904.

Proteomic databases

PaxDbiP0C264.
PRIDEiP0C264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612221; ENSP00000483467; ENSG00000231274.
GeneIDi100130827.
KEGGihsa:100130827.
UCSCiuc032ifx.1. human.

Organism-specific databases

CTDi100130827.
GeneCardsiSBK3.
HGNCiHGNC:44121. SBK3.
neXtProtiNX_P0C264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiP0C264.
KOiK08858.
OMAiGRCVSAH.
PhylomeDBiP0C264.

Enzyme and pathway databases

SignaLinkiP0C264.

Miscellaneous databases

GenomeRNAii100130827.
NextBioi20773008.
PROiP0C264.

Gene expression databases

ExpressionAtlasiP0C264. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSBK3_HUMAN
AccessioniPrimary (citable) accession number: P0C264
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.